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    ZRT2 low-affinity Zn(2+) transporter ZRT2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850821, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ZRT2
    Official Full Name
    low-affinity Zn(2+) transporter ZRT2
    Primary source
    SGD:S000004120
    Locus tag
    YLR130C
    See related
    AllianceGenome:SGD:S000004120; FungiDB:YLR130C; VEuPathDB:YLR130C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables low-affinity zinc ion transmembrane transporter activity. Involved in zinc ion import across plasma membrane. Located in plasma membrane. Orthologous to human SLC39A1 (solute carrier family 39 member 1); SLC39A2 (solute carrier family 39 member 2); and SLC39A3 (solute carrier family 39 member 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ZRT2 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (402794..404062, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene NEDD8 ligase DCN1 Neighboring gene snoRNA-binding rRNA-processing protein DIP2 Neighboring gene DNA-binding transcription factor ACE2 Neighboring gene phosphoric diester hydrolase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The ZRT2 gene encodes the low affinity zinc transporter in Saccharomyces cerevisiae. Zhao H, et al. J Biol Chem, 1996 Sep 20. PMID 8798516
    2. The Zap1 transcriptional activator also acts as a repressor by binding downstream of the TATA box in ZRT2. Bird AJ, et al. EMBO J, 2004 Mar 10. PMID 14976557, Free PMC Article
    3. Promotion of Zn(2+) uptake by Al (3+) in a Saccharomyces Cerevisiae mutant that lacks the ZRT1 gene encoding a high-affinity Zn transporter. Tamura S, et al. Biol Trace Elem Res, 2008 Sep. PMID 18463798
    4. Zinc deficiency-inducible OsZIP8 encodes a plasma membrane-localized zinc transporter in rice. Lee S, et al. Mol Cells, 2010 Jun. PMID 20496122
    5. Defect of zinc transporter ZRT1 ameliorates cadmium induced lipid accumulation in Saccharomyces cerevisiae. Rajakumar S, et al. Metallomics, 2016 Apr. PMID 26999708

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables low-affinity zinc ion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables low-affinity zinc ion transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables monoatomic cation transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    enables zinc ion transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in transition metal ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in zinc ion import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in zinc ion import across plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in zinc ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in zinc ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    low-affinity Zn(2+) transporter ZRT2
    NP_013231.1
    • Low-affinity zinc transporter of the plasma membrane; transcription is induced under low-zinc conditions by the Zap1p transcription factor

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      402794..404062 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182017.1 → NP_013231.1  TPA: low-affinity Zn(2+) transporter ZRT2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013231.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VYC5, Q12436
      UniProtKB/TrEMBL
      B3LT91, C7GQC5, C8ZD99, N1P6M6
      Conserved Domains (1) summary
      pfam02535
      Location:24 → 419
      Zip; ZIP Zinc transporter
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12436.1

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