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    FCF2 Fcf2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850740, updated on 9-Dec-2024

    Summary

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    Official Symbol
    FCF2
    Official Full Name
    Fcf2p
    Primary source
    SGD:S000004041
    Locus tag
    YLR051C
    See related
    AllianceGenome:SGD:S000004041; FungiDB:YLR051C; VEuPathDB:YLR051C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); and endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Located in nucleolus. Orthologous to human DNTTIP2 (deoxynucleotidyltransferase terminal interacting protein 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See FCF2 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (246324..246977, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Mlo50p Neighboring gene Ema19p Neighboring gene Ies3p Neighboring gene Nrs1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The complete structure of the small-subunit processome. Barandun J, et al. Nat Struct Mol Biol, 2017 Nov. PMID 28945246
    2. Fcf1p and Fcf2p are novel nucleolar Saccharomyces cerevisiae proteins involved in pre-rRNA processing. Rempola B, et al. Biochem Biophys Res Commun, 2006 Jul 28. PMID 16762320
    3. Artificial intelligence-assisted cryoEM structure of Bfr2-Lcp5 complex observed in the yeast small subunit processome. Zhao Y, et al. Commun Biol, 2022 Jun 1. PMID 35650250, Free PMC Article
    4. Nop9 is an RNA binding protein present in pre-40S ribosomes and required for 18S rRNA synthesis in yeast. Thomson E, et al. RNA, 2007 Dec. PMID 17956976, Free PMC Article
    5. Pwp2 mediates UTP-B assembly via two structurally independent domains. Boissier F, et al. Sci Rep, 2017 Jun 9. PMID 28600509, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. localized to the nucleolus; involved in pre-rRNA processing
      Title: Fcf1p and Fcf2p are novel nucleolar Saccharomyces cerevisiae proteins involved in pre-rRNA processing.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleolus HDA PubMed 
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Fcf2p
    NP_013152.1
    • Nucleolar protein involved in the early steps of 35S rRNA processing; interacts with Faf1p; member of a transcriptionally co-regulated set of genes called the RRB regulon; essential gene

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      246324..246977 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181938.1 → NP_013152.1  TPA: Fcf2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013152.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VY53, Q12035
      UniProtKB/TrEMBL
      G2WIP4, N1NZG0
      Conserved Domains (1) summary
      pfam08698
      Location:102 → 190
      Fcf2; Fcf2 pre-rRNA processing
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12035.1

    Gene LinkOut

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