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    MBR1 Mbr1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853769, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MBR1
    Official Full Name
    Mbr1p
    Primary source
    SGD:S000001576
    Locus tag
    YKL093W
    See related
    AllianceGenome:SGD:S000001576; FungiDB:YKL093W; VEuPathDB:YKL093W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in aerobic respiration. Predicted to be located in mitochondrion. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See MBR1 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (264789..265808)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene mRNA splicing protein YJU2 Neighboring gene acylglycerol lipase Neighboring gene GTPase-activating protein BUD2 Neighboring gene phosphatidylinositol/phosphatidylcholine-binding protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of nuclear genes which participate to mitochondrial translation in Saccharomyces cerevisiae. Valens M, et al. Biochimie, 1991 Dec. PMID 1725263
    2. MBR1 and MBR3, two related yeast genes that can suppress the growth defect of hap2, hap3 and hap4 mutants. Daignan-Fornier B, et al. Mol Gen Genet, 1994 Jun 3. PMID 8208248
    3. The MBR1 gene from Saccharomyces cerevisiae is activated by and required for growth under sub-optimal conditions. Reisdorf P, et al. Mol Gen Genet, 1997 Jul. PMID 9267436
    4. Strand-specific RNA sequencing reveals extensive regulated long antisense transcripts that are conserved across yeast species. Yassour M, et al. Genome Biol, 2010. PMID 20796282, Free PMC Article
    5. The protein factor-arrest 11 (Far11) is essential for the toxicity of human caspase-10 in yeast and participates in the regulation of autophagy and the DNA damage signaling. Lisa-Santamaría P, et al. J Biol Chem, 2012 Aug 24. PMID 22782902, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in aerobic respiration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Mbr1p
    NP_012830.1
    • Protein involved in mitochondrial functions and stress response; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants; MBR1 has a paralog, ISF1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      264789..265808
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179659.1 → NP_012830.1  TPA: Mbr1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012830.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C8ZC82, D6VXJ5, P23493, Q2VQW7
      UniProtKB/TrEMBL
      G2WHU0, N1NZ45
      Conserved Domains (1) summary
      pfam17058
      Location:29 → 248
      MBR1; Mitochondrial biogenesis regulation protein 1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P23493.2

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