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    UGA1 4-aminobutyrate transaminase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852902, updated on 9-Dec-2024

    Summary

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    Official Symbol
    UGA1
    Official Full Name
    4-aminobutyrate transaminase
    Primary source
    SGD:S000003251
    Locus tag
    YGR019W
    See related
    AllianceGenome:SGD:S000003251; FungiDB:YGR019W; VEuPathDB:YGR019W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable pyridoxal phosphate binding activity. Involved in gamma-aminobutyric acid catabolic process. Located in cytosol. Human ortholog(s) of this gene implicated in Alzheimer's disease; GABA aminotransferase deficiency; and Huntington's disease. Orthologous to human ABAT (4-aminobutyrate aminotransferase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See UGA1 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (525229..526644)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene H(+)-transporting V1 sector ATPase subunit F Neighboring gene Dpc29p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nucleotide sequence of the yeast UGA1 gene encoding GABA transaminase. André B, et al. Nucleic Acids Res, 1990 May 25. PMID 2190186, Free PMC Article
    2. The DAL81 gene product is required for induced expression of two differently regulated nitrogen catabolic genes in Saccharomyces cerevisiae. Bricmont PA, et al. Mol Cell Biol, 1991 Feb. PMID 1990272, Free PMC Article
    3. The UGA3 gene regulating the GABA catabolic pathway in Saccharomyces cerevisiae codes for a putative zinc-finger protein acting on RNA amount. André B. Mol Gen Genet, 1990 Jan. PMID 2109179
    4. Common features and differences in the expression of the three genes forming the UGA regulon in Saccharomyces cerevisiae. Cardillo SB, et al. Biochem Biophys Res Commun, 2011 Jul 15. PMID 21708130
    5. GABA metabolism pathway genes, UGA1 and GAD1, regulate replicative lifespan in Saccharomyces cerevisiae. Kamei Y, et al. Biochem Biophys Res Commun, 2011 Apr 1. PMID 21371425

    See all (55) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. AtGABA-T is functionally interchangeable with ScGABA-TKG for GABA growth, thermotolerance and limiting production of ROS, regardless of location in mitochondria or cytosol of yeast cells, but AtGABA-T is about half as efficient in doing so as ScGABA-TKG.
      Title: GABA transaminases from Saccharomyces cerevisiae and Arabidopsis thaliana complement function in cytosol and mitochondria.
    2. GAD1, UGA1 and UGA2 mediates thermotolerance by reducing reactive oxygen production.
      Title: GABA shunt mediates thermotolerance in Saccharomyces cerevisiae by reducing reactive oxygen production.
    3. UGA1 and UGA2, are subject to amino acid regulation as it occurs for UGA4.
      Title: Common features and differences in the expression of the three genes forming the UGA regulon in Saccharomyces cerevisiae.
    4. UGA1 and GAD1 were identified as aging genes.
      Title: GABA metabolism pathway genes, UGA1 and GAD1, regulate replicative lifespan in Saccharomyces cerevisiae.
    5. UGA1 (GABA aminotransferase) transaminates only gamma-aminobutyrate and not beta-alanine.
      Title: A gene duplication led to specialized gamma-aminobutyrate and beta-alanine aminotransferase in yeast.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables 4-aminobutyrate:2-oxoglutarate transaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 4-aminobutyrate:2-oxoglutarate transaminase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables pyridoxal phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in gamma-aminobutyric acid catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in gamma-aminobutyric acid catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in gamma-aminobutyric acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    4-aminobutyrate transaminase
    NP_011533.3
    • Gamma-aminobutyrate (GABA) transaminase; also known as 4-aminobutyrate aminotransferase; involved in the 4-aminobutyrate and glutamate degradation pathways; required for normal oxidative stress tolerance and nitrogen utilization; protein abundance increases in response to DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      525229..526644
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181148.3 → NP_011533.3  TPA: 4-aminobutyrate transaminase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011533.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A5H0J7, D6VUF4, P17649
      UniProtKB/TrEMBL
      A6ZV09, B3LIJ9, B5VIY0, C7GK87, G2WEB0, N1P3S6
      Conserved Domains (1) summary
      TIGR00699
      Location:5 → 468
      GABAtrns_euk; 4-aminobutyrate aminotransferase, eukaryotic type
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P17649.2

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