GGA1 ubiquitin-binding protein [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: GGA1
Official Full Name: ubiquitin-binding protein
Primary source: SGD:S000002766
Locus tag: YDR358W
See related: AllianceGenome:SGD:S000002766; FungiDB:YDR358W; VEuPathDB:YDR358W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables ubiquitin binding activity. Involved in Golgi to endosome transport; Golgi to vacuole transport; and protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway. Located in trans-Golgi network. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to several human genes including GGA1 (golgi associated, gamma adaptin ear containing, ARF binding protein 1); GGA2 (golgi associated, gamma adaptin ear containing, ARF binding protein 2); and GGA3 (golgi associated, gamma adaptin ear containing, ARF binding protein 3). [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables phosphatidylinositol binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin binding	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin binding	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Golgi to endosome transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in Golgi to endosome transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in Golgi to vacuole transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in Golgi to vacuole transport	IGI Inferred from Genetic Interaction more info	PubMed
involved_in Golgi to vacuole transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cytosolic transport	IEA Inferred from Electronic Annotation more info
involved_in endosomal transport	IEA Inferred from Electronic Annotation more info
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vacuolar transport	IEA Inferred from Electronic Annotation more info
involved_in vesicle-mediated transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in cytosol	HDA more info	PubMed
is_active_in trans-Golgi network	IBA Inferred from Biological aspect of Ancestor more info
located_in trans-Golgi network	IDA Inferred from Direct Assay more info	PubMed

NP_010645.1

Golgi-localized protein with homology to gamma-adaptin; interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner in order to facilitate traffic through the late Golgi; GGA1 has a paralog, GGA2, that arose from the whole genome duplication

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