RAD34 Rad34p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: RAD34
Official Full Name: Rad34p
Primary source: SGD:S000002722
Locus tag: YDR314C
See related: AllianceGenome:SGD:S000002722; FungiDB:YDR314C; VEuPathDB:YDR314C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Predicted to enable damaged DNA binding activity and single-stranded DNA binding activity. Involved in nucleotide-excision repair. Located in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See RAD34 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 1

Sequence:: Chromosome: IV; NC_001136.10 (1090433..1092511, complement)

Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that Rad4p is essential for repair in the intergenic spacer and the transcription initiation site, while Rad34p is necessary for transcription-coupled NER that starts about 40 nucleotides downstream of the transcription initiation site.
Title: Complementary roles of yeast Rad4p and Rad34p in nucleotide excision repair of active and inactive rRNA gene chromatin.
the two homologous proteins Rad4 and YDR314C are both involved in nucleotide excision repair and probably have a similar function, but operate at different loci in the genome and are unable to replace each other
Title: The Rad4 homologue YDR314C is essential for strand-specific repair of RNA polymerase I-transcribed rDNA in Saccharomyces cerevisiae.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables damaged DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables damaged DNA binding	IEA Inferred from Electronic Annotation more info
enables molecular_function	ND No biological Data available more info
enables single-stranded DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in mismatch repair	IBA Inferred from Biological aspect of Ancestor more info
involved_in nucleotide-excision repair	IBA Inferred from Biological aspect of Ancestor more info
involved_in nucleotide-excision repair	IEA Inferred from Electronic Annotation more info
involved_in nucleotide-excision repair	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of XPC complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
part_of nucleotide-excision repair factor 2 complex	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	HDA more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Rad34p

NP_010600.1

Protein involved in nucleotide excision repair (NER); homologous to RAD4

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001136.10 Reference assembly

Range

1090433..1092511 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180622.1 → NP_010600.1 TPA: Rad34p [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010600.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VSU3, Q06665

UniProtKB/TrEMBL

A6ZYR2, B3LFY2, B5VGJ3, N1P752

Conserved Domains (1) summary

COG5535
Location:2 → 682

RAD4; DNA repair protein RAD4 [DNA replication, recombination, and repair]