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    GYP7 GTPase-activating protein GYP7 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851364, updated on 9-Dec-2024

    Summary

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    Official Symbol
    GYP7
    Official Full Name
    GTPase-activating protein GYP7
    Primary source
    SGD:S000002393
    Locus tag
    YDL234C
    See related
    AllianceGenome:SGD:S000002393; FungiDB:YDL234C; VEuPathDB:YDL234C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables GTPase activator activity. Involved in regulation of vacuole fusion, non-autophagic and vesicle-mediated transport. Located in cytoplasm. Is active in late endosome. Orthologous to several human genes including TBC1D17 (TBC1 domain family member 17). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See GYP7 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (34237..36477, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene 4-nitrophenylphosphatase Neighboring gene Ypd1p Neighboring gene Mfg1p Neighboring gene olichyl-diphosphooligosaccharide--protein glycotransferase OST4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. High expression cloning, purification, and assay of Ypt-GTPase-activating proteins. Vollmer P, et al. Methods Enzymol, 1995. PMID 8583913
    2. Primary structure and biochemical characterization of yeast GTPase-activating proteins with substrate preference for the transport GTPase Ypt7p. Vollmer P, et al. Eur J Biochem, 1999 Feb. PMID 10091609
    3. The GTPase activating protein Gyp7 regulates Rab7/Ypt7 activity on late endosomes. Füllbrunn N, et al. J Cell Biol, 2024 Jun 3. PMID 38536036, Free PMC Article
    4. Sequential action of two GTPases to promote vacuole docking and fusion. Eitzen G, et al. EMBO J, 2000 Dec 15. PMID 11118206, Free PMC Article
    5. TBC-domain GAPs for Rab GTPases accelerate GTP hydrolysis by a dual-finger mechanism. Pan X, et al. Nature, 2006 Jul 20. PMID 16855591

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The GTPase activating protein Gyp7 regulates Rab7/Ypt7 activity on late endosomes.
      Title: The GTPase activating protein Gyp7 regulates Rab7/Ypt7 activity on late endosomes.
    2. Results show that the GTPase-activating protein Gyp7 inactivates the yeast vacuole Rab Ypt7 in vivo, with downstream assistance from an inhibitory casein kinase I, Yck3.
      Title: Efficient termination of vacuolar Rab GTPase signaling requires coordinated action by a GAP and a protein kinase.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of vacuole fusion, non-autophagic IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vesicle-mediated transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol HDA PubMed 
    is_active_in late endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    GTPase-activating protein GYP7
    NP_010047.1
    • GTPase-activating protein for yeast Rab family members; members include Ypt7p (most effective), Ypt1p, Ypt31p, and Ypt32p (in vitro); involved in vesicle mediated protein trafficking; regulates Ypt7p activity on late endosomes; contains a PH-like domain

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      34237..36477 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180294.1 → NP_010047.1  TPA: GTPase-activating protein GYP7 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010047.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VRC2, P48365
      UniProtKB/TrEMBL
      A6ZXA0, B3LHB0, C7GJQ3, C8Z6N7, N1P7L2
      Conserved Domains (1) summary
      COG5210
      Location:134 → 738
      COG5210; GTPase-activating protein [General function prediction only]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P48365.1

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