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    OST4 olichyl-diphosphooligosaccharide--protein glycotransferase OST4 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851366, updated on 9-Dec-2024

    Summary

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    Official Symbol
    OST4
    Official Full Name
    olichyl-diphosphooligosaccharide--protein glycotransferase OST4
    Primary source
    SGD:S000002391
    Locus tag
    YDL232W
    See related
    AllianceGenome:SGD:S000002391; FungiDB:YDL232W; VEuPathDB:YDL232W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables protein-macromolecule adaptor activity. Involved in protein N-linked glycosylation. Located in endoplasmic reticulum membrane. Part of oligosaccharyltransferase complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See OST4 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (38487..38597)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene GTPase-activating protein GYP7 Neighboring gene Mfg1p Neighboring gene Bre4p Neighboring gene tyrosine protein phosphatase PTP1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The OST4 gene of Saccharomyces cerevisiae encodes an unusually small protein required for normal levels of oligosaccharyltransferase activity. Chi JH, et al. J Biol Chem, 1996 Feb 9. PMID 8621712
    2. A novel and simple method of production and biophysical characterization of a mini-membrane protein, Ost4p: a subunit of yeast oligosaccharyl transferase. Kumar A, et al. Biopolymers, 2012 Jul. PMID 22302405, Free PMC Article
    3. Production and biophysical characterization of a mini-membrane protein, Ost4V23D: A functionally important mutant of yeast oligosaccharyltransferase subunit Ost4p. Chaudhary B, et al. Protein Expr Purif, 2017 Nov. PMID 28728943
    4. (1)H, (13)C, (15)N resonance assignments and secondary structure of yeast oligosaccharyltransferase subunit Ost4 and its functionally important mutant Ost4V23D. Chaudhary BP, et al. Biomol NMR Assign, 2020 Oct. PMID 32328881
    5. NMR and MD simulations reveal the impact of the V23D mutation on the function of yeast oligosaccharyltransferase subunit Ost4. Chaudhary BP, et al. Glycobiology, 2021 Aug 7. PMID 33442744

    See all (63) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ost4p is required for the incorporation of either Ost3p or Ost6p into the oligosaccharyltransferase complex
      Title: The 3.4-kDa Ost4 protein is required for the assembly of two distinct oligosaccharyltransferase complexes in yeast.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables protein-macromolecule adaptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein N-linked glycosylation IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    part_of oligosaccharyltransferase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    olichyl-diphosphooligosaccharide--protein glycotransferase OST4
    NP_010049.1
    • Subunit of the oligosaccharyltransferase complex of the ER lumen; complex catalyzes protein asparagine-linked glycosylation; type I membrane protein required for incorporation of Ost3p or Ost6p into the OST complex

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      38487..38597
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180292.1 → NP_010049.1  TPA: olichyl-diphosphooligosaccharide--protein glycotransferase OST4 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010049.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VRC4, Q99380
      UniProtKB/TrEMBL
      A6ZXA2, B3LHA8, C7GJQ1, C8Z6N8, G2WBT7, N1P441
      Conserved Domains (1) summary
      pfam10215
      Location:1 → 33
      Ost4; Oligosaccaryltransferase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99380.1

    Gene LinkOut

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