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    KIP2 Kip2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855948, updated on 9-Dec-2024

    Summary

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    Official Symbol
    KIP2
    Official Full Name
    Kip2p
    Primary source
    SGD:S000006076
    Locus tag
    YPL155C
    See related
    AllianceGenome:SGD:S000006076; FungiDB:YPL155C; VEuPathDB:YPL155C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables microtubule plus end polymerase; plus-end-directed microtubule motor activity; and tubulin binding activity. Involved in microtubule polymerization; negative regulation of microtubule depolymerization; and nuclear migration along microtubule. Located in cortical microtubule plus-end and spindle pole body. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See KIP2 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (257216..259336, complement)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene RNA methyltransferase Neighboring gene pheromone-regulated protein PRM4 Neighboring gene proteinase A Neighboring gene serine/threonine/tyrosine protein kinase RAD53

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Kinesin Kip2 enhances microtubule growth in vitro through length-dependent feedback on polymerization and catastrophe. Hibbel A, et al. Elife, 2015 Nov 18. PMID 26576948, Free PMC Article
    2. The Kar3p and Kip2p motors function antagonistically at the spindle poles to influence cytoplasmic microtubule numbers. Huyett A, et al. J Cell Sci, 1998 Feb. PMID 9427678
    3. Cell cycle control of kinesin-mediated transport of Bik1 (CLIP-170) regulates microtubule stability and dynein activation. Carvalho P, et al. Dev Cell, 2004 Jun. PMID 15177030
    4. Kinesin-related proteins required for assembly of the mitotic spindle. Roof DM, et al. J Cell Biol, 1992 Jul. PMID 1618910, Free PMC Article
    5. Role of Kip2 during early mitosis - impact on spindle pole body separation and chromosome capture. Augustine B, et al. J Cell Sci, 2018 Jun 11. PMID 29739877

    See all (69) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The motor domain of the kinesin Kip2 promotes microtubule polymerization at microtubule tips.
      Title: The motor domain of the kinesin Kip2 promotes microtubule polymerization at microtubule tips.
    2. The maintenance of Kip2p level and cytoplasmic microtubules lengths during early cell division is important to ensure coordination between spindle pole bodies separation and chromosome capture by kinetochore microtubules.
      Title: Role of Kip2 during early mitosis - impact on spindle pole body separation and chromosome capture.
    3. The budding yeast kinesin Kip2 is a microtubule polymerase and catastrophe inhibitor in vitro that uses its processive motor activity as part of a feedback loop to further promote microtubule growth.
      Title: Kinesin Kip2 enhances microtubule growth in vitro through length-dependent feedback on polymerization and catastrophe.
    4. Yeast GSK-3 kinase regulates astral microtubule function through phosphorylation of the microtubule-stabilizing kinesin Kip2
      Title: Yeast GSK-3 kinase regulates astral microtubule function through phosphorylation of the microtubule-stabilizing kinesin Kip2.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cytoskeletal motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule plus end polymerase IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables microtubule plus end polymerase IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables plus-end-directed microtubule motor activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables plus-end-directed microtubule motor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables tubulin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables tubulin binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in microtubule polymerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in microtubule polymerization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in microtubule-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule-based movement IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in microtubule-based movement IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of microtubule depolymerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of microtubule depolymerization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of microtubule depolymerization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nuclear migration along microtubule IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cortical microtubule plus-end IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of kinesin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of kinesin complex TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in spindle pole body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Kip2p
    NP_015170.1
    • Kinesin-related motor protein and plus-end directed microtubule (MT) polymerase; involved in mitotic spindle positioning, nuclear migration, microtubule polymerization and inhibition of MT catastrophe; stabilizes microtubules by targeting Bik1p to the MT plus end; Kip2p levels are controlled during the cell cycle

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      257216..259336 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183969.1 → NP_015170.1  TPA: Kip2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015170.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3L3, P28743
      UniProtKB/TrEMBL
      A6ZW98, B3LKS2, C7GJA7, C8ZIM3, N1NW11
      Conserved Domains (2) summary
      TIGR02168
      Location:445 → 698
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd01374
      Location:102 → 493
      KISc_CENP_E; Kinesin motor domain, CENP-E/KIP2-like subgroup
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P28743.1

    Gene LinkOut

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