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    DSL1 Dsl1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855463, updated on 9-Dec-2024

    Summary

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    Official Symbol
    DSL1
    Official Full Name
    Dsl1p
    Primary source
    SGD:S000005202
    Locus tag
    YNL258C
    See related
    AllianceGenome:SGD:S000005202; FungiDB:YNL258C; VEuPathDB:YNL258C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    RNS1
    Summary
    Involved in ER-dependent peroxisome organization and retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Located in endoplasmic reticulum and nucleus. Part of Dsl1/NZR complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See DSL1 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (158109..160373, complement)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene ribosome biosynthesis protein LTO1 Neighboring gene copper metallochaperone ATX1 Neighboring gene Sip3p Neighboring gene trifunctional dihydropteroate synthetase/dihydrohydroxymethylpterin pyrophosphokinase/dihydroneopterin aldolase FOL1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Isolation of Saccharomyces cerevisiae RNase T1 hypersensitive (rns) mutants and genetic analysis of the RNS1/DSL1 gene. Ishikawa T, et al. J Gen Appl Microbiol, 2005 Apr. PMID 15942868
    2. Crystal structure of alpha-COP in complex with epsilon-COP provides insight into the architecture of the COPI vesicular coat. Hsia KC, et al. Proc Natl Acad Sci U S A, 2010 Jun 22. PMID 20534429, Free PMC Article
    3. Dsl1p, an essential component of the Golgi-endoplasmic reticulum retrieval system in yeast, uses the same sequence motif to interact with different subunits of the COPI vesicle coat. Andag U, et al. J Biol Chem, 2003 Dec 19. PMID 14504276
    4. Structure of a membrane tethering complex incorporating multiple SNAREs. DAmico KA, et al. Nat Struct Mol Biol, 2024 Feb. PMID 38196032, Free PMC Article
    5. Golgi-to-endoplasmic reticulum (ER) retrograde traffic in yeast requires Dsl1p, a component of the ER target site that interacts with a COPI coat subunit. Reilly BA, et al. Mol Biol Cell, 2001 Dec. PMID 11739780, Free PMC Article

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SNARE-mediated homotypic ER fusion requires DSL1.
      Title: ER-associated retrograde SNAREs and the Dsl1 complex mediate an alternative, Sey1p-independent homotypic ER fusion pathway.
    2. subunits of the Dsl1 complex (Dsl1, Dsl3, and Tip20), as well as the SNAREs Ufe1 and Sec20, are ER-resident proteins that do not seem to move into COPII vesicles.
      Title: The Dsl1 protein tethering complex is a resident endoplasmic reticulum complex, which interacts with five soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptors (SNAREs): implications for fusion and fusion regulation.
    3. a direct role of the Dsl1 complex, in particular Tip20p, in the formation and stabilization of ER SNARE complexes.
      Title: The Dsl1 tethering complex actively participates in soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor (SNARE) complex assembly at the endoplasmic reticulum in Saccharomyces cerevisiae.
    4. Studies indicate that Dsl1 tethering complex seems to be designed to expose an unstructured domain of Dsl1p at its top, which is required to capture vesicles.
      Title: Dsl1p/Zw10: common mechanisms behind tethering vesicles and microtubules.
    5. Study determined the structure of the Dsl1 complex, revealing a tower containing at its base the binding sites for two endoplasmic reticulum SNAREs and at its tip a flexible lasso for capturing vesicles.
      Title: A structure-based mechanism for vesicle capture by the multisubunit tethering complex Dsl1.
    6. SEC20, SEC39, and DSL1 are essential secretory genes involved in the early stages of peroxisome assembly
      Title: Endoplasmic reticulum-associated secretory proteins Sec20p, Sec39p, and Dsl1p are involved in peroxisome biogenesis.
    7. Crystal structures show 2 of the 3 subunits, Tip20p and Dsl1p, resemble known subunits of the exocyst complex, establishing a structural connection among tethering complexes and implying that many of their subunits are derived from a common progenitor.
      Title: Structural characterization of Tip20p and Dsl1p, subunits of the Dsl1p vesicle tethering complex.
    8. DSL1 is required for the stable interaction of the SNARE Use1p with a central subcomplex consisting of Tip20p and the SNARE proteins Ufe1p and Sec20p.
      Title: Dsl1p, Tip20p, and the novel Dsl3(Sec39) protein are required for the stability of the Q/t-SNARE complex at the endoplasmic reticulum in yeast.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in ER-dependent peroxisome organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic spindle assembly checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Dsl1/NZR complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Dsl1/NZR complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of RZZ complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol HDA PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Dsl1p
    NP_014141.1
    • Peripheral membrane protein needed for Golgi-to-ER retrograde traffic; mediates Sey1p-independent homotypic ER fusion; forms Dsl1 tethering complex with Sec39p and Tip20p that forms a stable complex with ER SNAREs Sec20p, Ufe1p and Use1p and is functionally conserved from yeast to mammalian cells; component of the ER target site that interacts with coatomer; interacts with different subunits of COPI vesicle coat; interacts with Cin5p; homolog of fly and human ZW10 gene

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      158109..160373 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183096.1 → NP_014141.1  TPA: Dsl1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014141.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W0T5, P53847
      UniProtKB/TrEMBL
      A6ZRI5, C7GPA3, C8ZFX9
      Conserved Domains (2) summary
      pfam11989
      Location:560 → 753
      Dsl1_C; Retrograde transport protein Dsl1 C terminal
      pfam11988
      Location:6 → 360
      Dsl1_N; Retrograde transport protein Dsl1 N terminal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53847.1

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