U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    MTC6 Mtc6p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856556, updated on 2-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    MTC6
    Official Full Name
    Mtc6p
    Primary source
    SGD:S000001194
    Locus tag
    YHR151C
    See related
    AllianceGenome:SGD:S000001194; FungiDB:YHR151C; VEuPathDB:YHR151C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in cellular response to hydrostatic pressure. Located in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Nov 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See MTC6 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (399268..400848, complement)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene Skg6p Neighboring gene Pex28p Neighboring gene Spo12p Neighboring gene Spo16p

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Mtc6/Ehg2 is a novel endoplasmic reticulum-resident glycoprotein essential for high-pressure tolerance. Uemura S, et al. J Biochem, 2024 Jul 31. PMID 38621657
    2. Role of a novel endoplasmic reticulum-resident glycoprotein Mtc6/Ehg2 in high-pressure growth: stability of tryptophan permease Tat2 in Saccharomyces cerevisiae. Kato Y, et al. Biosci Biotechnol Biochem, 2024 Aug 26. PMID 38918055
    3. Early steps in autophagy depend on direct phosphorylation of Atg9 by the Atg1 kinase. Papinski D, et al. Mol Cell, 2014 Feb 6. PMID 24440502, Free PMC Article
    4. Screening the yeast "disruptome" for mutants affecting resistance to the immunosuppressive drug, mycophenolic acid. Desmoucelles C, et al. J Biol Chem, 2002 Jul 26. PMID 12016207
    5. Identification of genes affecting vacuole membrane fragmentation in Saccharomyces cerevisiae. Michaillat L, et al. PLoS One, 2013. PMID 23383298, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to hydrostatic pressure IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Mtc6p
    NP_012021.1
    • ER-resident glycoprotein involved in high-pressure tolerance; proposed role promoting proper folding of nutrient permeases in the ER during hydrostatic pressure stress; contains two transmembrane domains, a C-terminal cytoplasmic domain and a luminal region containing 12 N-linked glycans; null mutant is synthetically sick with cdc13-1; SWAT-GFP and mCherry fusion proteins localize to the vacuole while SWAT-GFP fusion also localizes to the endoplasmic reticulum

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      399268..400848 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179282.1 → NP_012021.1  TPA: Mtc6p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012021.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A6ZT59, B3LSR5, B5VK80, C8Z9U8, D3DLA0, P38849
      UniProtKB/TrEMBL
      G2WFM4, N1P9G6
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38849.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools