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    LSB3 Lsb3p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850580, updated on 2-Nov-2024

    Summary

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    Official Symbol
    LSB3
    Official Full Name
    Lsb3p
    Primary source
    SGD:S000002968
    Locus tag
    YFR024C-A
    See related
    AllianceGenome:SGD:S000002968; FungiDB:YFR024C-A; VEuPathDB:YFR024C-A
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    YFR024C
    Summary
    Predicted to enable actin filament binding activity and phosphatidylinositol binding activity. Involved in actin cortical patch localization. Located in cellular bud neck and mitochondrion. Orthologous to human SH3YL1 (SH3 and SYLF domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See LSB3 in Genome Data Viewer
    Location:
    chromosome: VI
    Exon count:
    2
    Sequence:
    Chromosome: VI; NC_001138.5 (201960..203433, complement)

    Chromosome VI - NC_001138.5Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Pes4p Neighboring gene histidinol-phosphatase Neighboring gene tRNA-Ala

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001138.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Optimization of specificity in a cellular protein interaction network by negative selection. Zarrinpar A, et al. Nature, 2003 Dec 11. PMID 14668868
    2. Mechanism of actin capping protein recruitment and turnover during clathrin-mediated endocytosis. Lamb AK, et al. J Cell Biol, 2024 Jan 1. PMID 37966720, Free PMC Article
    3. The Saccharomyces cerevisiae homologue of human Wiskott-Aldrich syndrome protein Las17p interacts with the Arp2/3 complex. Madania A, et al. Mol Biol Cell, 1999 Oct. PMID 10512884, Free PMC Article
    4. Endocytic proteins with prion-like domains form viscoelastic condensates that enable membrane remodeling. Bergeron-Sandoval LP, et al. Proc Natl Acad Sci U S A, 2021 Dec 14. PMID 34887356, Free PMC Article
    5. Characterization of the yeast trimeric-SAS acetyltransferase complex. Shia WJ, et al. J Biol Chem, 2005 Mar 25. PMID 15659401

    See all (72) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Our analysis suggests a novel role for the SH3 domains of Lsb3p and Lsb4p as hubs that recruit and assemble several endocytic complexes.
      Title: Bayesian modeling of the yeast SH3 domain interactome predicts spatiotemporal dynamics of endocytosis proteins.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables phosphatidylinositol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin cortical patch localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin cortical patch localization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in actin cortical patch localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in actin filament bundle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in actin cortical patch IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cellular bud neck HDA PubMed 
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    Lsb3p
    NP_219497.4
    • Protein containing a C-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; protein abundance increases in response to DNA replication stress; LSB3 has a paralog, YSC84, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001138.5 Reference assembly

      Range
      201960..203433 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180865.3 → NP_219497.4  TPA: Lsb3p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_219497.4

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A7A261, D6VTQ4, P43603
      UniProtKB/TrEMBL
      C7GYC9, C8Z7V9, N1P394
      Conserved Domains (2) summary
      cd11842
      Location:404 → 458
      SH3_Ysc84p_like; Src homology 3 domain of Ysc84p and similar fungal proteins
      COG2930
      Location:1 → 219
      SYLF; Lipid-binding SYLF domain [Lipid transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P43603.3

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