CSH1 mannosylinositol phosphorylceramide synthase catalytic subunit CSH1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: CSH1
Official Full Name: mannosylinositol phosphorylceramide synthase catalytic subunit CSH1
Primary source: SGD:S000000365
Locus tag: YBR161W
See related: AllianceGenome:SGD:S000000365; FungiDB:YBR161W; VEuPathDB:YBR161W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables inositol phosphorylceramide mannosyltransferase activity. Involved in glycosphingolipid biosynthetic process. Located in fungal-type vacuole. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See CSH1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 1

Sequence:: Chromosome: II; NC_001134.8 (561634..562764)

Chromosome II - NC_001134.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pleiotropic roles of N-glycans for enzyme activities and stabilities of MIPC synthases, Csh1 and Sur1/Csg1, in Saccharomyces cerevisiae.
Title: Pleiotropic roles of N-glycans for enzyme activities and stabilities of MIPC synthases, Csh1 and Sur1/Csg1, in Saccharomyces cerevisiae.
Csg2 has several regulatory functions for Csg1 and Csh1, including stability, transport, and gene expression
Title: Regulation of the transport and protein levels of the inositol phosphorylceramide mannosyltransferases Csg1 and Csh1 by the Ca2+-binding protein Csg2.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables inositol phosphorylceramide mannosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables inositol phosphorylceramide mannosyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables mannosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in glycosphingolipid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in glycosphingolipid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in inositol phosphoceramide metabolic process	IEA Inferred from Electronic Annotation more info
involved_in mannosyl-inositol phosphorylceramide biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in sphingolipid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in fungal-type vacuole	HDA more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in vacuolar membrane	IEA Inferred from Electronic Annotation more info
located_in vacuole	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: mannosylinositol phosphorylceramide synthase catalytic subunit CSH1

NP_009719.3

EC 2.4.1.370

Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit; forms a complex with regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Sur1p; CSH1 has a paralog, SUR1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001134.8 Reference assembly

Range

561634..562764

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001178509.3 → NP_009719.3 TPA: mannosylinositol phosphorylceramide synthase catalytic subunit CSH1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_009719.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VQF6, P38287

UniProtKB/TrEMBL

A6ZLA3, B3LMZ8, B5VEB7, C7GUH5, D3UEQ5, G2W9G3, N1PAU1

Conserved Domains (1) summary

COG3774
Location:1 → 332

OCH1; Mannosyltransferase OCH1 or related enzyme [Cell wall/membrane/envelope biogenesis]