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    Necab2 N-terminal EF-hand calcium binding protein 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 170928, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Necab2provided by RGD
    Official Full Name
    N-terminal EF-hand calcium binding protein 2provided by RGD
    Primary source
    RGD:621844
    See related
    EnsemblRapid:ENSRNOG00000015084 AllianceGenome:RGD:621844
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Efcbp2
    Summary
    Predicted to enable A2A adenosine receptor binding activity; identical protein binding activity; and type 5 metabotropic glutamate receptor binding activity. Predicted to be involved in positive regulation of protein localization to membrane; regulation of amyloid precursor protein biosynthetic process; and regulation of signal transduction. Is active in postsynapse and presynapse. Orthologous to human NECAB2 (N-terminal EF-hand calcium binding protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 67.9) and Adrenal (RPKM 8.8) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Necab2 in Genome Data Viewer
    Location:
    19q12
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (64409627..64436371)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (47501351..47527722)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (52086325..52112633)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120098609 Neighboring gene oxidative stress induced growth inhibitor 1 Neighboring gene solute carrier family 38, member 8 Neighboring gene membrane-bound transcription factor peptidase, site 1 Neighboring gene hydroxysteroid dehydrogenase like 1 Neighboring gene dynein, axonemal, assembly factor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. TRPV1, Targeted by miR-338-3p, Induces Neuropathic Pain by Interacting with NECAB2. Ma Y, et al. J Mol Neurosci, 2021 Jan. PMID 32557241
    2. The neuronal Ca(2+) -binding protein 2 (NECAB2) interacts with the adenosine A(2A) receptor and modulates the cell surface expression and function of the receptor. Canela L, et al. Mol Cell Neurosci, 2007 Sep. PMID 17689978
    3. The association of metabotropic glutamate receptor type 5 with the neuronal Ca2+-binding protein 2 modulates receptor function. Canela L, et al. J Neurochem, 2009 Oct. PMID 19694902
    4. NECABs: a family of neuronal Ca(2+)-binding proteins with an unusual domain structure and a restricted expression pattern. Sugita S, et al. Neuroscience, 2002. PMID 12044471
    5. Pooled-matrix protein interaction screens using Barcode Fusion Genetics. Yachie N, et al. Mol Syst Biol, 2016 Apr 22. PMID 27107012, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TRPV1, Targeted by miR-338-3p, Induces Neuropathic Pain by Interacting with NECAB2.
      Title: TRPV1, Targeted by miR-338-3p, Induces Neuropathic Pain by Interacting with NECAB2.
    2. NECAB2 by its physical interaction with mGlu(5b) receptor modulates receptor function
      Title: The association of metabotropic glutamate receptor type 5 with the neuronal Ca2+-binding protein 2 modulates receptor function.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables A2A adenosine receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables A2A adenosine receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables type 5 metabotropic glutamate receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables type 5 metabotropic glutamate receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in calcium-mediated signaling NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of G protein-coupled receptor internalization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of G protein-coupled receptor internalization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of ERK1 and ERK2 cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of adenosine receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of adenosine receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of glutamate receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of glutamate receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein localization to membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of protein localization to membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of amyloid precursor protein biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in presynapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    N-terminal EF-hand calcium-binding protein 2
    Names
    EF hand calcium binding protein 2
    neuronal calcium binding 2
    neuronal calcium-binding protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133415.2 → NP_596906.2  N-terminal EF-hand calcium-binding protein 2

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/Swiss-Prot
      F1LQY6, Q9ESB4
      UniProtKB/TrEMBL
      A0A5H1ZRU5
      Related
      ENSRNOP00000100370.1, ENSRNOT00000148837.1
      Conserved Domains (2) summary
      pfam03992
      Location:254 → 324
      ABM; Antibiotic biosynthesis monooxygenase
      pfam13499
      Location:30 → 89
      EF-hand_7; EF-hand domain pair

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      64409627..64436371
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063277747.1 → XP_063133817.1  N-terminal EF-hand calcium-binding protein 2 isoform X3

    2. XM_063277745.1 → XP_063133815.1  N-terminal EF-hand calcium-binding protein 2 isoform X1

    3. XM_063277746.1 → XP_063133816.1  N-terminal EF-hand calcium-binding protein 2 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F1LQY6.3 GenPept UniProtKB/Swiss-Prot:F1LQY6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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