Smad7 SMAD family member 7 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Smad7provided by RGD
Official Full Name: SMAD family member 7provided by RGD
Primary source: RGD:69314
See related: EnsemblRapid:ENSRNOG00000018359 AllianceGenome:RGD:69314
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Madh7
Summary: Enables ubiquitin protein ligase binding activity. Involved in intracellular signal transduction; negative regulation of DNA-templated transcription; and regulation of transforming growth factor beta receptor signaling pathway. Predicted to be located in several cellular components, including adherens junction; centrosome; and nuclear lumen. Predicted to be part of heteromeric SMAD protein complex. Predicted to be active in plasma membrane. Biomarker of nephritis and pulmonary hypertension. Human ortholog(s) of this gene implicated in colorectal cancer and pancreatic adenocarcinoma. Orthologous to human SMAD7 (SMAD family member 7). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 153.2), Thymus (RPKM 100.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 18q12.2

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	18	NC_086036.1 (71263508..71291849)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	18	NC_051353.1 (68988429..69016774)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	18	NC_005117.4 (71395830..71424164)

Chromosome 18 - NC_086036.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mir-195-5p targets Smad7 regulation of the Wnt/beta-catenin pathway to promote osteogenic differentiation of vascular smooth muscle cells.
Title: Mir-195-5p targets Smad7 regulation of the Wnt/β-catenin pathway to promote osteogenic differentiation of vascular smooth muscle cells.
Diabetic and nondiabetic BMSC-derived exosomes affect bone regeneration via regulating miR-17-5p/SMAD7 axis.
Title: Diabetic and nondiabetic BMSC-derived exosomes affect bone regeneration via regulating miR-17-5p/SMAD7 axis.
Smad7 Is Highly Expressed in Human Degenerative Discs and Participates in IL-1beta-Induced Apoptosis of Rat AF Cells via the Mitochondria Pathway.
Title: Smad7 Is Highly Expressed in Human Degenerative Discs and Participates in IL-1β-Induced Apoptosis of Rat AF Cells via the Mitochondria Pathway.
Circ_0058792 regulates osteogenic differentiation through miR-181a-5p/Smad7 axis in steroid-induced osteonecrosis of the femoral head.
Title: Circ_0058792 regulates osteogenic differentiation through miR-181a-5p/Smad7 axis in steroid-induced osteonecrosis of the femoral head.
TP53-mediated miR-2861 promotes osteogenic differentiation of BMSCs by targeting Smad7.
Title: TP53-mediated miR-2861 promotes osteogenic differentiation of BMSCs by targeting Smad7.
MiR-410-3p facilitates Angiotensin II-induced cardiac hypertrophy by targeting Smad7.
Title: MiR-410-3p facilitates Angiotensin II-induced cardiac hypertrophy by targeting Smad7.
Interference of TGF-beta1/Smad7 signal pathway affects myocardial fibrosis in hypertension.
Title: Interference of TGF-β1/Smad7 signal pathway affects myocardial fibrosis in hypertension.
Inhibition of microRNA-150-5p alleviates cardiac inflammation and fibrosis via targeting Smad7 in high glucose-treated cardiac fibroblasts.
Title: Inhibition of microRNA-150-5p alleviates cardiac inflammation and fibrosis via targeting Smad7 in high glucose-treated cardiac fibroblasts.
Synergistic effects may exist among Smad4, Smad7 and caveolin-1 in carcinogenesis of oral cancer.
Title: [Significance of Smad4, Smad7 and Caveolin-1 expression in oral mucosa carcinogenesis of Wistar rats].
Human umbilical cord mesenchymal stem cells exosomes may promote Smad7 expression by inhibiting miR125b5p to increase myocardial repair in the rat acute myocardial infarction model.
Title: Exosomes derived from human umbilical cord mesenchymal stem cells improve myocardial repair via upregulation of Smad7.

Submit: New GeneRIF Correction See all GeneRIFs (59)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Smad7 (e-PCR), detects polymorphism
- UniSTS:466574

PMC193708P2 (e-PCR)
- UniSTS:271760

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables I-SMAD binding	IBA Inferred from Biological aspect of Ancestor more info
enables I-SMAD binding	IEA Inferred from Electronic Annotation more info
enables I-SMAD binding	ISO Inferred from Sequence Orthology more info
enables activin receptor binding	IEA Inferred from Electronic Annotation more info
enables activin receptor binding	ISO Inferred from Sequence Orthology more info
enables beta-catenin binding	IEA Inferred from Electronic Annotation more info
enables beta-catenin binding	ISO Inferred from Sequence Orthology more info
enables collagen binding	IEA Inferred from Electronic Annotation more info
enables collagen binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription corepressor activity	IEA Inferred from Electronic Annotation more info
enables transcription corepressor activity	ISO Inferred from Sequence Orthology more info
enables transcription regulator inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription regulator inhibitor activity	IEA Inferred from Electronic Annotation more info
enables transcription regulator inhibitor activity	ISO Inferred from Sequence Orthology more info
enables type I transforming growth factor beta receptor binding	IEA Inferred from Electronic Annotation more info
enables type I transforming growth factor beta receptor binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin-like ligase-substrate adaptor activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin-like ligase-substrate adaptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in SMAD protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in SMAD protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in adherens junction assembly	IEA Inferred from Electronic Annotation more info
involved_in adherens junction assembly	ISO Inferred from Sequence Orthology more info
involved_in anatomical structure morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in artery morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in artery morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in beta-catenin destruction complex disassembly	ISO Inferred from Sequence Orthology more info
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to leukemia inhibitory factor	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to leukemia inhibitory factor	ISO Inferred from Sequence Orthology more info
involved_in cellular response to transforming growth factor beta stimulus	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of BMP signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of BMP signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of BMP signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of SMAD protein signal transduction	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of SMAD protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of T cell cytokine production	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of T cell cytokine production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of T-helper 17 cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of T-helper 17 cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of T-helper 17 type immune response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of activin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of activin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of chondrocyte proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of chondrocyte proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of ossification	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of ossification	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of peptidyl-threonine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by competitive promoter binding	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by competitive promoter binding	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transforming growth factor beta receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transforming growth factor beta receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell-cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell-cell adhesion mediated by cadherin	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of chondrocyte hypertrophy	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of chondrocyte hypertrophy	ISO Inferred from Sequence Orthology more info
involved_in protein stabilization	IEA Inferred from Electronic Annotation more info
involved_in protein stabilization	ISO Inferred from Sequence Orthology more info
involved_in protein-containing complex disassembly	ISO Inferred from Sequence Orthology more info
involved_in protein-containing complex localization	IEA Inferred from Electronic Annotation more info
involved_in protein-containing complex localization	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of cardiac muscle contraction	IEA Inferred from Electronic Annotation more info
involved_in regulation of cardiac muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in regulation of epithelial to mesenchymal transition	IEA Inferred from Electronic Annotation more info
involved_in regulation of epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transforming growth factor beta receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of ventricular cardiac muscle cell membrane depolarization	IEA Inferred from Electronic Annotation more info
involved_in regulation of ventricular cardiac muscle cell membrane depolarization	ISO Inferred from Sequence Orthology more info
involved_in response to laminar fluid shear stress	IEA Inferred from Electronic Annotation more info
involved_in response to laminar fluid shear stress	ISO Inferred from Sequence Orthology more info
involved_in transforming growth factor beta receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in ureteric bud development	IEA Inferred from Electronic Annotation more info
involved_in ureteric bud development	ISO Inferred from Sequence Orthology more info
involved_in ventricular cardiac muscle tissue morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in ventricular cardiac muscle tissue morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in ventricular septum morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in ventricular septum morphogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in adherens junction	IEA Inferred from Electronic Annotation more info
located_in adherens junction	ISO Inferred from Sequence Orthology more info
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in fibrillar center	IEA Inferred from Electronic Annotation more info
located_in fibrillar center	ISO Inferred from Sequence Orthology more info
part_of heteromeric SMAD protein complex	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
part_of transcription regulator complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: mothers against decapentaplegic homolog 7

Names: MAD (mothers against decapentaplegic, Drosophila) homolog 7; MAD homolog 7; SMAD 7; mothers against DPP homolog 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_030858.2 → NP_110485.1 mothers against decapentaplegic homolog 7

See identical proteins and their annotated locations for NP_110485.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000018

UniProtKB/Swiss-Prot

O88406, Q9QUG1

UniProtKB/TrEMBL

A0A0G2JSQ5

Related

ENSRNOP00000024831.2, ENSRNOT00000024831.6

Conserved Domains (2) summary

cd10494
Location:60 → 205

MH1_SMAD_7; N-terminal Mad Homology 1 (MH1) domain in SMAD7

cd10500
Location:254 → 424

MH2_SMAD_7; C-terminal Mad Homology 2 (MH2) domain in SMAD7

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086036.1 Reference GRCr8

Range

71263508..71291849

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006254959.5 → XP_006255021.1 mothers against decapentaplegic homolog 7 isoform X1

UniProtKB/Swiss-Prot

O88406, Q9QUG1

Conserved Domains (2) summary

cd10494
Location:60 → 205

MH1_SMAD_7; N-terminal Mad Homology 1 (MH1) domain in SMAD7

cd10500
Location:253 → 423

MH2_SMAD_7; C-terminal Mad Homology 2 (MH2) domain in SMAD7
XM_039097138.2 → XP_038953066.1 mothers against decapentaplegic homolog 7 isoform X2

Conserved Domains (1) summary

cd10500
Location:63 → 233

MH2_SMAD_7; C-terminal Mad Homology 2 (MH2) domain in SMAD7