Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pik3r3provided by RGD
Official Full Name: phosphoinositide-3-kinase regulatory subunit 3provided by RGD
Primary source: RGD:621042
See related: EnsemblRapid:ENSRNOG00000000145 AllianceGenome:RGD:621042
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables 1-phosphatidylinositol-3-kinase regulator activity. Predicted to be involved in several processes, including cell migration involved in sprouting angiogenesis; insulin receptor signaling pathway; and positive regulation of macromolecule metabolic process. Predicted to be part of phosphatidylinositol 3-kinase complex, class IA. Biomarker of hepatocellular carcinoma. Human ortholog(s) of this gene implicated in colon adenocarcinoma. Orthologous to human PIK3R3 (phosphoinositide-3-kinase regulatory subunit 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 170.7), Lung (RPKM 127.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q35

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (134936790..135009303)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (129700925..129772591)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (135069972..135145633)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Western blot and mRNA analyses showed that p55gamma expression declined in balloon-injured carotid arteries.
Title: Identification of PI3K regulatory subunit p55γ as a novel inhibitor of vascular smooth muscle cell proliferation and neointimal formation.

Submit: New GeneRIF Correction

General gene information

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Markers

RH144265 (e-PCR)
- UniSTS:233510

D5Rat201 (e-PCR), detects polymorphism
- UniSTS:227900

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 1-phosphatidylinositol-3-kinase regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables 1-phosphatidylinositol-3-kinase regulator activity	IDA Inferred from Direct Assay more info	PubMed
enables 1-phosphatidylinositol-3-kinase regulator activity	IEA Inferred from Electronic Annotation more info
enables 1-phosphatidylinositol-3-kinase regulator activity	ISO Inferred from Sequence Orthology more info
enables phosphotyrosine residue binding	IEA Inferred from Electronic Annotation more info
enables phosphotyrosine residue binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell migration involved in sprouting angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in cell migration involved in sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in insulin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in insulin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within insulin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of phosphatidylinositol 3-kinase complex	IEA Inferred from Electronic Annotation more info
part_of phosphatidylinositol 3-kinase complex	ISO Inferred from Sequence Orthology more info
part_of phosphatidylinositol 3-kinase complex, class IA	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: phosphatidylinositol 3-kinase regulatory subunit gamma

Names: PI3-kinase p85 subunit gamma; PI3-kinase regulatory subunit gamma; PI3-kinase subunit p55-gamma; PI3K regulatory subunit gamma; p55PIK; phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 3 (p55); phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma; phosphatidylinositol 3-kinase p55 subunit; phosphoinositide-3-kinase, regulatory subunit 3 (gamma); ptdIns-3-kinase p85-gamma; ptdIns-3-kinase regulatory subunit gamma; ptdIns-3-kinase regulatory subunit p55-gamma

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001429916.1 → NP_001416845.1 phosphatidylinositol 3-kinase regulatory subunit gamma isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

Q63789

UniProtKB/TrEMBL

A6JZ71, G3V605
NM_001429917.1 → NP_001416846.1 phosphatidylinositol 3-kinase regulatory subunit gamma isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

Q63789

UniProtKB/TrEMBL

A6JZ71, G3V605
NM_001429918.1 → NP_001416847.1 phosphatidylinositol 3-kinase regulatory subunit gamma isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

Q63789

UniProtKB/TrEMBL

A6JZ71, G3V605
NM_001429919.1 → NP_001416848.1 phosphatidylinositol 3-kinase regulatory subunit gamma isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

Q63789
NM_001429920.1 → NP_001416849.1 phosphatidylinositol 3-kinase regulatory subunit gamma isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

Q63789
NM_001429921.1 → NP_001416850.1 phosphatidylinositol 3-kinase regulatory subunit gamma isoform 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005
NM_001429922.1 → NP_001416851.1 phosphatidylinositol 3-kinase regulatory subunit gamma isoform 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005
NM_001429923.1 → NP_001416852.1 phosphatidylinositol 3-kinase regulatory subunit gamma isoform 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005
NM_022213.3 → NP_071549.2 phosphatidylinositol 3-kinase regulatory subunit gamma isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

Q63789

UniProtKB/TrEMBL

A6JZ71, G3V605

Related

ENSRNOP00000000157.2, ENSRNOT00000000157.5

Conserved Domains (3) summary

cd09930
Location:351 → 454

SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85

cd09942
Location:59 → 167

SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85

cl25402
Location:172 → 332

iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

134936790..135009303

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039110699.2 → XP_038966627.1 phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1

Conserved Domains (3) summary

cd09930
Location:351 → 454

SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85

cd09942
Location:59 → 167

SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85

cl25402
Location:172 → 332

iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
XM_006238714.4 → XP_006238776.1 phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1

Conserved Domains (3) summary

cd09930
Location:351 → 454

SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85

cd09942
Location:59 → 167

SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85

cl25402
Location:172 → 332

iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
XM_039110698.2 → XP_038966626.1 phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1

Conserved Domains (3) summary

cd09930
Location:351 → 454

SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85

cd09942
Location:59 → 167

SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85

cl25402
Location:172 → 332

iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits