Ptp4a1 protein tyrosine phosphatase 4A1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Ptp4a1provided by RGD
Full Name: protein tyrosine phosphatase 4A1provided by RGD
Primary source: RGD:61970
See related: EnsemblRapid:ENSRNOG00000011771 AllianceGenome:RGD:61970
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: PRL-1
Summary: Enables protein tyrosine phosphatase activity. Predicted to be involved in positive regulation of cell migration. Predicted to be located in cytoplasmic side of plasma membrane. Predicted to be active in cytoplasm and nucleus. Orthologous to human PTP4A1 (protein tyrosine phosphatase 4A1). [provided by Alliance of Genome Resources, Nov 2024]
Annotation information: Note: The loci 103693189 and 29463 are annotated independently on Rnor_6.0 (Annotation Release 105) assembly. [04 Jun 2015]
Expression: Biased expression in Adrenal (RPKM 601.9), Muscle (RPKM 570.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q21

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (40710250..40718176, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (33214201..33245046, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (37223363..37254222, complement)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Increased phosphatase regenerating liver-1 trigger vascular remodeling in injured ovary via platelet-derived growth factor signaling pathway.
Title: Increased phosphatase regenerating liver-1 trigger vascular remodeling in injured ovary via platelet-derived growth factor signaling pathway.
Activation of the EGFR-PI3K-CaM pathway by PRL-1-overexpressing placenta-derived mesenchymal stem cells ameliorates liver cirrhosis via ER stress-dependent calcium.
Title: Activation of the EGFR-PI3K-CaM pathway by PRL-1-overexpressing placenta-derived mesenchymal stem cells ameliorates liver cirrhosis via ER stress-dependent calcium.
genes induced by FSH in rat Sertoli cells would also show hormonal regulation during rat folliculogenesis
Title: Regulation of protein tyrosine phosphatase 4a1, B-cell translocation gene 2, nuclear receptor subfamily 4a1 and diacylglycerol O-acyltransferase 1 by follicle stimulating hormone in the rat ovary.

Submit: New GeneRIF Correction

General gene information

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Markers

RH128958 (e-PCR)
- UniSTS:212266

D6S1236E (e-PCR)
- UniSTS:151105

Ptp4a1 (e-PCR), detects polymorphism
- UniSTS:527509

RH140279 (e-PCR)
- UniSTS:222357

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables histone H2AXY142 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables non-membrane spanning protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine phosphatase activity, metal-dependent	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in early endosome	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in spindle	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein tyrosine phosphatase type IVA 1

Names: protein tyrosine phosphatase 4a1-like; protein tyrosine phosphatase type IVA, member 1; protein-tyrosine phosphatase of regenerating liver 1

NP_113767.1

EC 3.1.3.48

XP_063122883.1

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031579.3 → NP_113767.1 protein tyrosine phosphatase type IVA 1

Status: VALIDATED

Source sequence(s)

BC097307, JAXUCZ010000009

UniProtKB/Swiss-Prot

Q4QRA5, Q78EG7, Q8VH48

UniProtKB/TrEMBL

A0A8I5Y1B8, A6IN79

Related

ENSRNOP00000016237.2, ENSRNOT00000016237.5

Conserved Domains (1) summary

cd18537
Location:1 → 167

PTP-IVa1; protein tyrosine phosphatase type IVA 1