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    Osgin1 oxidative stress induced growth inhibitor 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 171493, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Osgin1provided by RGD
    Official Full Name
    oxidative stress induced growth inhibitor 1provided by RGD
    Primary source
    RGD:620679
    See related
    EnsemblRapid:ENSRNOG00000014948 AllianceGenome:RGD:620679
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Okl38
    Summary
    Predicted to enable growth factor activity. Predicted to be involved in negative regulation of cell growth. Orthologous to human OSGIN1 (oxidative stress induced growth inhibitor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 337.0), Liver (RPKM 295.4) and 4 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Osgin1 in Genome Data Viewer
    Location:
    19q12
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (64380336..64409165)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (47471750..47500517)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (52056808..52085491)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene malonyl-CoA decarboxylase Neighboring gene uncharacterized LOC120098609 Neighboring gene N-terminal EF-hand calcium binding protein 2 Neighboring gene solute carrier family 38, member 8 Neighboring gene membrane-bound transcription factor peptidase, site 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Congenital asymptomatic absence of pericardium. Sivaprasad M, et al. Indian J Chest Dis Allied Sci, 1992 Jul-Sep. PMID 1302223
    2. Structural characterization of three novel rat OKL38 transcripts, their tissue distributions, and their regulation by human chorionic gonadotropin. Ong CK, et al. Endocrinology, 2004 Oct. PMID 15217983
    3. Cloning and characterization of a novel pregnancy-induced growth inhibitor in mammary gland. Huynh H, et al. Endocrinology, 2001 Aug. PMID 11459809
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables growth factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables growth factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of cell growth IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    oxidative stress-induced growth inhibitor 1
    Names
    pregnancy-induced growth inhibitor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001433950.1 → NP_001420879.1  oxidative stress-induced growth inhibitor 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/TrEMBL
      A0A0G2K4C7, F7EN26, Q8R430

    2. NM_001433954.1 → NP_001420883.1  oxidative stress-induced growth inhibitor 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/TrEMBL
      A0A0G2K4C7, F7EN26, Q8R430

    3. NM_001433956.1 → NP_001420885.1  oxidative stress-induced growth inhibitor 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/TrEMBL
      A0A0G2K4C7, F7EN26, Q8R430

    4. NM_001433957.1 → NP_001420886.1  oxidative stress-induced growth inhibitor 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/TrEMBL
      A0A0G2K4C7, F7EN26, Q8R430

    5. NM_138504.3 → NP_612513.1  oxidative stress-induced growth inhibitor 1

      See identical proteins and their annotated locations for NP_612513.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/TrEMBL
      A0A0G2K4C7, F7EN26, Q8R430
      Conserved Domains (3) summary
      PRK12770
      Location:243 → 319
      PRK12770; putative glutamate synthase subunit beta; Provisional
      cl21454
      Location:168 → 303
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
      cl39093
      Location:240 → 447
      Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      64380336..64409165
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006255706.5 → XP_006255768.1  oxidative stress-induced growth inhibitor 1 isoform X1

      See identical proteins and their annotated locations for XP_006255768.1

      UniProtKB/TrEMBL
      A0A0G2K4C7, F7EN26, Q8R430
      Conserved Domains (3) summary
      PRK12770
      Location:243 → 319
      PRK12770; putative glutamate synthase subunit beta; Provisional
      cl21454
      Location:168 → 303
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
      cl39093
      Location:240 → 447
      Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase

    2. XM_063277754.1 → XP_063133824.1  oxidative stress-induced growth inhibitor 1 isoform X1

    3. XM_063277762.1 → XP_063133832.1  oxidative stress-induced growth inhibitor 1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K4C7, F7EN26, Q8R430

    4. XM_063277760.1 → XP_063133830.1  oxidative stress-induced growth inhibitor 1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K4C7, F7EN26, Q8R430

    5. XM_063277755.1 → XP_063133825.1  oxidative stress-induced growth inhibitor 1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K4C7, F7EN26, Q8R430

    6. XM_039097445.2 → XP_038953373.1  oxidative stress-induced growth inhibitor 1 isoform X1

      Conserved Domains (3) summary
      PRK12770
      Location:243 → 319
      PRK12770; putative glutamate synthase subunit beta; Provisional
      cl21454
      Location:168 → 303
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
      cl39093
      Location:240 → 447
      Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase

    7. XM_039097446.2 → XP_038953374.1  oxidative stress-induced growth inhibitor 1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K4C7, F7EN26, Q8R430
      Conserved Domains (3) summary
      PRK12770
      Location:243 → 319
      PRK12770; putative glutamate synthase subunit beta; Provisional
      cl21454
      Location:168 → 303
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
      cl39093
      Location:240 → 447
      Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase

    8. XM_039097443.2 → XP_038953371.1  oxidative stress-induced growth inhibitor 1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K4C7, F7EN26, Q8R430
      Conserved Domains (3) summary
      PRK12770
      Location:243 → 319
      PRK12770; putative glutamate synthase subunit beta; Provisional
      cl21454
      Location:168 → 303
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
      cl39093
      Location:240 → 447
      Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase

    9. XM_039097447.2 → XP_038953375.1  oxidative stress-induced growth inhibitor 1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K4C7, F7EN26, Q8R430
      Conserved Domains (3) summary
      PRK12770
      Location:243 → 319
      PRK12770; putative glutamate synthase subunit beta; Provisional
      cl21454
      Location:168 → 303
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
      cl39093
      Location:240 → 447
      Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase

    10. XM_063277759.1 → XP_063133829.1  oxidative stress-induced growth inhibitor 1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K4C7, F7EN26, Q8R430
      Related
      ENSRNOP00000020225.3, ENSRNOT00000020225.7

    11. XM_063277756.1 → XP_063133826.1  oxidative stress-induced growth inhibitor 1 isoform X1

    12. XM_063277757.1 → XP_063133827.1  oxidative stress-induced growth inhibitor 1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K4C7, F7EN26, Q8R430

    13. XM_063277761.1 → XP_063133831.1  oxidative stress-induced growth inhibitor 1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K4C7, F7EN26, Q8R430

    14. XM_063277763.1 → XP_063133833.1  oxidative stress-induced growth inhibitor 1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K4C7, F7EN26, Q8R430

    15. XM_063277758.1 → XP_063133828.1  oxidative stress-induced growth inhibitor 1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K4C7, F7EN26, Q8R430
    Nucleotide Protein Strain
    Heading Accession and Version

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