Lilrb4 leukocyte immunoglobulin like receptor B4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Lilrb4provided by RGD
Official Full Name: leukocyte immunoglobulin like receptor B4provided by RGD
Primary source: RGD:1359090
See related: EnsemblRapid:ENSRNOG00000027811 AllianceGenome:RGD:1359090
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Gp49b; GP49B2
Summary: Predicted to enable several functions, including apolipoprotein binding activity; fibronectin binding activity; and transmembrane receptor protein tyrosine kinase inhibitor activity. Predicted to be involved in several processes, including negative regulation of cytokine production; regulation of leukocyte activation; and regulation of signal transduction. Predicted to be located in cell surface. Predicted to be active in plasma membrane. Orthologous to human LILRB4 (leukocyte immunoglobulin like receptor B4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Lung (RPKM 129.2), Kidney (RPKM 103.1) and 8 other tissues See more
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Genomic context

Location:: 1q12

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (78847685..78853294, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (69805020..69810628, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (73393854..73399448, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Lilrb4 ameliorates ileal injury in rats with hemorrhagic shock and suppresses the activation of NF-kappaB signaling pathway.
Title: Lilrb4 ameliorates ileal injury in rats with hemorrhagic shock and suppresses the activation of NF-κB signaling pathway.
Compared to mouse, the cytoplasmic domain of rat gp49B contains a third ITIM-like sequence
Title: The rat orthologue to the inhibitory receptor gp49B is expressed by neutrophils and monocytes, but not by NK cells or mast cells.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables apolipoprotein binding	ISO Inferred from Sequence Orthology more info
enables fibronectin binding	ISO Inferred from Sequence Orthology more info
enables protein phosphatase binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor inhibitor activity	ISO Inferred from Sequence Orthology more info
enables transmembrane receptor protein tyrosine kinase inhibitor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Fc receptor mediated inhibitory signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in immune response-regulating signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in interleukin-10-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in mast cell activation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of IP-10 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of T cell costimulation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of T cell cytokine production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of T cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of activated T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of chemokine production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cytokine production involved in inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cytotoxic T cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-1 beta production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-10 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-2 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-5 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of miRNA transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of monocyte activation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of osteoclast differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein localization to nucleus	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of signaling receptor activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of type II interferon production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of CD8-positive, alpha-beta T cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell anergy	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of regulatory T cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in receptor internalization	ISO Inferred from Sequence Orthology more info
involved_in tolerance induction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: leukocyte immunoglobulin like receptor B4

Names: glycoprotein 49b; leukocyte immunoglobulin-like receptor, subfamily B, member 4; leukocyte surface receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001013894.2 → NP_001013916.1 leukocyte immunoglobulin like receptor B4 isoform 3 precursor

See identical proteins and their annotated locations for NP_001013916.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A0A0G2JVH3, E9PTH5, Q67EV2

Related

ENSRNOP00000030632.5, ENSRNOT00000038898.6

Conserved Domains (1) summary

cl11960
Location:124 → 218

Ig; Immunoglobulin domain
NM_001419406.1 → NP_001406335.1 leukocyte immunoglobulin like receptor B4 isoform 1 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

Q67EV3

Related

ENSRNOP00000069484.1, ENSRNOT00000077186.3
NM_001419407.1 → NP_001406336.1 leukocyte immunoglobulin like receptor B4 isoform 2 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A0A8I6GJM6

Related

ENSRNOP00000092281.1, ENSRNOT00000110970.2
NM_001419408.1 → NP_001406337.1 leukocyte immunoglobulin like receptor B4 isoform 4 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

Related

ENSRNOP00000083730.1, ENSRNOT00000098988.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

78847685..78853294 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039103862.2 → XP_038959790.1 leukocyte immunoglobulin like receptor B4 isoform X3

UniProtKB/TrEMBL

A0A8I6A0J7

Conserved Domains (2) summary

cd00096
Location:29 → 33

Ig; Ig strand A [structural motif]

cl11960
Location:29 → 123

Ig; Immunoglobulin domain
XM_039103861.2 → XP_038959789.1 leukocyte immunoglobulin like receptor B4 isoform X2

UniProtKB/TrEMBL

A0A8I6A095, A0A8I6A469

Related

ENSRNOP00000083948.1, ENSRNOT00000095592.2

Conserved Domains (3) summary

cd00096
Location:124 → 128

Ig; Ig strand A [structural motif]

cd16843
Location:28 → 116

IgC2_D1_D2_LILR_KIR_like; Immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors, Natural killer inhibitory receptors (KIRs) and similar domains; member of Immunoglobulin Constant-2 set of IgSF domains

cl11960
Location:124 → 218

Ig; Immunoglobulin domain
XM_063283034.1 → XP_063139104.1 leukocyte immunoglobulin like receptor B4 isoform X6
XM_063283032.1 → XP_063139102.1 leukocyte immunoglobulin like receptor B4 isoform X5
XM_063283021.1 → XP_063139091.1 leukocyte immunoglobulin like receptor B4 isoform X1

Related

ENSRNOP00000087354.2, ENSRNOT00000109192.2
XM_063283028.1 → XP_063139098.1 leukocyte immunoglobulin like receptor B4 isoform X4