Ddx19b DEAD-box helicase 19B [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ddx19bprovided by RGD
Official Full Name: DEAD-box helicase 19Bprovided by RGD
Primary source: RGD:1593382
See related: EnsemblRapid:ENSRNOG00000064019 AllianceGenome:RGD:1593382
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Zd10a
Summary: Predicted to enable RNA helicase activity and mRNA binding activity. Predicted to be involved in poly(A)+ mRNA export from nucleus. Predicted to be located in nuclear envelope. Predicted to be active in cytoplasmic stress granule and nucleus. Orthologous to several human genes including DDX19B (DEAD-box helicase 19B). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 186.1), Thymus (RPKM 121.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 19q12

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (55877567..55910134, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (38968215..38998907, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (43217199..43246196)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

AI144819 (e-PCR)
- UniSTS:245023

SHGC-60774 (e-PCR)
- UniSTS:292

RH139434 (e-PCR)
- UniSTS:221520

Ddx19a (e-PCR), detects polymorphism
- UniSTS:479095

RH131624 (e-PCR)
- UniSTS:214907

RH142652 (e-PCR)
- UniSTS:231899

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables RNA helicase activity	IBA Inferred from Biological aspect of Ancestor more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in poly(A)+ mRNA export from nucleus	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasmic stress granule	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear envelope	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ATP-dependent RNA helicase DDX19B

Names: DEAD (Asp-Glu-Ala-As) box polypeptide 19B; DEAD (Asp-Glu-Ala-Asp) box polypeptide 19B; zinc responsive protein ZD10B; zinc responsive protein Zd10A

NP_001005895.3

EC 3.6.4.13

XP_008770756.1

EC 3.6.4.13

XP_038953928.1

EC 3.6.4.13

XP_063134361.1

EC 3.6.4.13

XP_063134362.1

EC 3.6.4.13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001005895.4 → NP_001005895.3 ATP-dependent RNA helicase DDX19B

Status: VALIDATED

Source sequence(s)

JAXUCZ010000019

UniProtKB/TrEMBL

Q5XLP8

Related

ENSRNOP00000069097.2, ENSRNOT00000084462.3

Conserved Domains (2) summary

cd18787
Location:307 → 443

SF2_C_DEAD; C-terminal helicase domain of the DEAD box helicases

cl28899
Location:75 → 303

DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086037.1 Reference GRCr8

Range

55877567..55910134 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063278292.1 → XP_063134362.1 ATP-dependent RNA helicase DDX19B isoform X2
XM_039098000.2 → XP_038953928.1 ATP-dependent RNA helicase DDX19B isoform X2

UniProtKB/TrEMBL

A0A0G2JY21

Conserved Domains (2) summary

cd18787
Location:198 → 334

SF2_C_DEAD; C-terminal helicase domain of the DEAD box helicases

cl28899
Location:1 → 187

DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily
XM_008772534.3 → XP_008770756.1 ATP-dependent RNA helicase DDX19B isoform X1

UniProtKB/TrEMBL

A0A8I6ADW1, A0A8I6GAE6

Related

ENSRNOP00000083150.1, ENSRNOT00000118121.2

Conserved Domains (3) summary

PTZ00424
Location:104 → 482

PTZ00424; helicase 45; Provisional

cd00079
Location:320 → 455

HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...

cd00268
Location:107 → 309

DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
XM_063278291.1 → XP_063134361.1 ATP-dependent RNA helicase DDX19B isoform X2