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    Ikzf4 IKAROS family zinc finger 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 100361923, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ikzf4provided by RGD
    Official Full Name
    IKAROS family zinc finger 4provided by RGD
    Primary source
    RGD:2319157
    See related
    EnsemblRapid:ENSRNOG00000005535 AllianceGenome:RGD:2319157
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; bHLH transcription factor binding activity; and zinc ion binding activity. Predicted to be involved in protein homooligomerization and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within negative regulation of DNA-templated transcription and positive regulation of transcription by RNA polymerase II. Predicted to be located in nuclear body. Predicted to be part of protein-containing complex. Orthologous to human IKZF4 (IKAROS family zinc finger 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 10.8), Lung (RPKM 6.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ikzf4 in Genome Data Viewer
    Location:
    7q11
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (1643379..1687524, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (1063283..1102940, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (3061422..3098142, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein S27a, pseudogene 11 Neighboring gene prefoldin subunit 1, pseudogene 1 Neighboring gene ribosomal protein S26 Neighboring gene sulfite oxidase Neighboring gene RAB5B, member RAS oncogene family Neighboring gene uncharacterized LOC120093528

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Eos: a novel member of the Ikaros gene family expressed predominantly in the developing nervous system. Honma Y, et al. FEBS Lett, 1999 Mar 19. PMID 10218586
    2. Structural studies on a protein-binding zinc-finger domain of Eos reveal both similarities and differences to classical zinc fingers. Westman BJ, et al. Biochemistry, 2004 Oct 26. PMID 15491138
    3. The Ikaros family protein Eos associates with C-terminal-binding protein corepressors. Perdomo J, et al. Eur J Biochem, 2002 Dec. PMID 12444977
    4. Myh7b/miR-499 gene expression is transcriptionally regulated by MRFs and Eos. Yeung F, et al. Nucleic Acids Res, 2012 Aug. PMID 22638570, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables bHLH transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein homooligomerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosolic ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in rough endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein Eos
    Names
    zinc finger protein, subfamily 1A, 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427287.1 → NP_001414216.1  zinc finger protein Eos

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A0A8I6AS15, A6KSG1
      Related
      ENSRNOP00000097096.1, ENSRNOT00000120270.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      1643379..1687524 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017595142.3 → XP_017450631.1  zinc finger protein Eos isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZN67, A6KSG2
      Related
      ENSRNOP00000079721.1, ENSRNOT00000119994.2
      Conserved Domains (2) summary
      sd00017
      Location:114 → 134
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:154 → 179
      zf-H2C2_2; Zinc-finger double domain

    2. XM_017595144.3 → XP_017450633.1  zinc finger protein Eos isoform X2

      UniProtKB/TrEMBL
      A6KSG2
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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