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    Cnksr1 connector enhancer of kinase suppressor of Ras 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 298545, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cnksr1provided by RGD
    Official Full Name
    connector enhancer of kinase suppressor of Ras 1provided by RGD
    Primary source
    RGD:1311879
    See related
    EnsemblRapid:ENSRNOG00000022838 AllianceGenome:RGD:1311879
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable protein-macromolecule adaptor activity. Predicted to be involved in synapse organization. Predicted to be located in cell cortex. Orthologous to human CNKSR1 (connector enhancer of kinase suppressor of Ras 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 58.6), Kidney (RPKM 39.3) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cnksr1 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (151731222..151742049, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (146447495..146458332, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (152447348..152458005, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene Uromoduilin-like Neighboring gene cation channel, sperm associated 4 Neighboring gene uncharacterized LOC120103003 Neighboring gene zinc finger protein 593 Neighboring gene similar to human chromosome 1 open reading frame 230

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The scaffold protein CNK1 interacts with the tumor suppressor RASSF1A and augments RASSF1A-induced cell death. Rabizadeh S, et al. J Biol Chem, 2004 Jul 9. PMID 15075335
    2. An ATIPical family of angiotensin II AT2 receptor-interacting proteins. Rodrigues-Ferreira S, et al. Trends Endocrinol Metab, 2010 Nov. PMID 20889352
    3. Human CNK1 acts as a scaffold protein, linking Rho and Ras signal transduction pathways. Jaffe AB, et al. Mol Cell Biol, 2004 Feb. PMID 14749388, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC124829

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein-macromolecule adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in synapse organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell cortex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    connector enhancer of kinase suppressor of ras 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039011.1 → NP_001034100.1  connector enhancer of kinase suppressor of ras 1

      See identical proteins and their annotated locations for NP_001034100.1

      Status: PROVISIONAL

      Source sequence(s)
      BC099788
      UniProtKB/TrEMBL
      A6IT10, Q499S0
      Conserved Domains (6) summary
      smart00454
      Location:4 → 69
      SAM; Sterile alpha motif
      cd00992
      Location:205 → 273
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01260
      Location:381 → 494
      PH_CNK_mammalian-like; Connector enhancer of KSR (Kinase suppressor of ras) (CNK) pleckstrin homology (PH) domain
      pfam00169
      Location:395 → 491
      PH; PH domain
      pfam10534
      Location:78 → 161
      CRIC_ras_sig; Connector enhancer of kinase suppressor of ras
      cl15755
      Location:4 → 70
      SAM_superfamily; SAM (Sterile alpha motif )

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      151731222..151742049 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063287451.1 → XP_063143521.1  connector enhancer of kinase suppressor of ras 1 isoform X3

      UniProtKB/TrEMBL
      G3V8W8
      Related
      ENSRNOP00000029346.4, ENSRNOT00000031225.6

    2. XM_039109635.1 → XP_038965563.1  connector enhancer of kinase suppressor of ras 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AI85
      Related
      ENSRNOP00000095433.2, ENSRNOT00000097555.2
      Conserved Domains (4) summary
      cd00992
      Location:300 → 364
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01260
      Location:472 → 585
      PH_CNK_mammalian-like; Connector enhancer of KSR (Kinase suppressor of ras) (CNK) pleckstrin homology (PH) domain
      pfam10534
      Location:142 → 225
      CRIC_ras_sig; Connector enhancer of kinase suppressor of ras
      cl15755
      Location:68 → 134
      SAM_superfamily; SAM (Sterile alpha motif )

    3. XM_063287450.1 → XP_063143520.1  connector enhancer of kinase suppressor of ras 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AI85

    4. XM_063287452.1 → XP_063143522.1  connector enhancer of kinase suppressor of ras 1 isoform X4

      UniProtKB/TrEMBL
      A0A8I6AI85

    5. XM_063287453.1 → XP_063143523.1  connector enhancer of kinase suppressor of ras 1 isoform X5

      UniProtKB/TrEMBL
      A0A8I6AN25, A6IT10
    Nucleotide Protein Strain
    Heading Accession and Version

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