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    Ptdss2 phosphatidylserine synthase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 293620, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ptdss2provided by RGD
    Official Full Name
    phosphatidylserine synthase 2provided by RGD
    Primary source
    RGD:1307914
    See related
    EnsemblRapid:ENSRNOG00000015912 AllianceGenome:RGD:1307914
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    PSS-2
    Summary
    Predicted to enable CDP-diacylglycerol-serine O-phosphatidyltransferase activity and L-serine-phosphatidylethanolamine phosphatidyltransferase activity. Predicted to act upstream of or within phosphatidylserine biosynthetic process. Predicted to be located in endoplasmic reticulum membrane. Orthologous to human PTDSS2 (phosphatidylserine synthase 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 90.3), Kidney (RPKM 88.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ptdss2 in Genome Data Viewer
    Location:
    1q41
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (205671024..205695556)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (196241439..196267632)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (214122981..214148011)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134485202 Neighboring gene anoctamin 9 Neighboring gene uncharacterized LOC102552971 Neighboring gene ribonuclease/angiogenin inhibitor 1 Neighboring gene U6 spliceosomal RNA Neighboring gene HRas proto-oncogene, GTPase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Defining the importance of phosphatidylserine synthase 2 in mice. Bergo MO, et al. J Biol Chem, 2002 Dec 6. PMID 12361952
    2. Phosphatidylserine synthase-1 and -2 are localized to mitochondria-associated membranes. Stone SJ, et al. J Biol Chem, 2000 Nov 3. PMID 10938271
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables CDP-diacylglycerol-serine O-phosphatidyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables L-serine-phosphatidylethanolamine phosphatidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables L-serine-phosphatidylethanolamine phosphatidyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in phosphatidylserine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phosphatidylserine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phosphatidylserine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    phosphatidylserine synthase 2
    Names
    ptdSer synthase 2
    serine-exchange enzyme II
    NP_001099786.1
    XP_038963828.1
    XP_063142634.1
    XP_063142638.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106316.1 → NP_001099786.1  phosphatidylserine synthase 2

      See identical proteins and their annotated locations for NP_001099786.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473953
      UniProtKB/Swiss-Prot
      B2GV22
      UniProtKB/TrEMBL
      A0A8I6AS39
      Related
      ENSRNOP00000021925.3, ENSRNOT00000021925.6
      Conserved Domains (1) summary
      pfam03034
      Location:98 → 378
      PSS; Phosphatidyl serine synthase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      205671024..205695556
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063286564.1 → XP_063142634.1  phosphatidylserine synthase 2 isoform X2

    2. XM_039107900.2 → XP_038963828.1  phosphatidylserine synthase 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AS39
      Conserved Domains (1) summary
      pfam03034
      Location:86 → 366
      PSS; Phosphatidyl serine synthase

    3. XM_063286568.1 → XP_063142638.1  phosphatidylserine synthase 2 isoform X3

      UniProtKB/TrEMBL
      A6HXP9
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B2GV22.1 GenPept UniProtKB/Swiss-Prot:B2GV22

    Gene LinkOut

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