U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    ADH3 alcohol dehydrogenase ADH3 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855107, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    ADH3
    Official Full Name
    alcohol dehydrogenase ADH3
    Primary source
    SGD:S000004688
    Locus tag
    YMR083W
    See related
    AllianceGenome:SGD:S000004688; FungiDB:YMR083W; VEuPathDB:YMR083W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables alcohol dehydrogenase (NAD+) activity. Involved in NADH oxidation and amino acid catabolic process to alcohol via Ehrlich pathway. Located in mitochondrial matrix. [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See ADH3 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (434788..435915)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Isf1p Neighboring gene uncharacterized protein Neighboring gene putative glutamine--fructose-6-phosphate transaminase Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Mutant alcohol dehydrogenase (ADH III) presequences that affect both in vitro mitochondrial import and in vitro processing by the matrix protease. Mooney DT, et al. Mol Cell Biol, 1990 Jun. PMID 2188098, Free PMC Article
    2. Primary structure requirements for correct sorting of the yeast mitochondrial protein ADH III to the yeast mitochondrial matrix space. Pilgrim D, et al. Mol Cell Biol, 1987 Jan. PMID 3550419, Free PMC Article
    3. The presequences of two imported mitochondrial proteins contain information for intracellular and intramitochondrial sorting. van Loon AP, et al. Cell, 1986 Mar 14. PMID 3004746
    4. The mitochondrial alcohol dehydrogenase Adh3p is involved in a redox shuttle in Saccharomyces cerevisiae. Bakker BM, et al. J Bacteriol, 2000 Sep. PMID 10940011, Free PMC Article
    5. Environmental systems biology of cold-tolerant phenotype in Saccharomyces species adapted to grow at different temperatures. Paget CM, et al. Mol Ecol, 2014 Nov. PMID 25243355, Free PMC Article

    See all (89) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. During zinc deficiency, Zap1 mediates the repression of two of the most abundant zinc-requiring enzymes.
      Title: Repression of ADH1 and ADH3 during zinc deficiency by Zap1-induced intergenic RNA transcripts.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables alcohol dehydrogenase (NAD+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alcohol dehydrogenase (NAD+) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables alcohol dehydrogenase (NAD+) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables butanol dehydrogenase (NAD+) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in NADH oxidation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in amino acid catabolic process to alcohol via Ehrlich pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    alcohol dehydrogenase ADH3
    NP_013800.1
    • Mitochondrial alcohol dehydrogenase isozyme III; involved in the shuttling of mitochondrial NADH to the cytosol under anaerobic conditions and ethanol production

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      434788..435915
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182582.1 → NP_013800.1  TPA: alcohol dehydrogenase ADH3 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013800.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZQ6, P07246
      UniProtKB/TrEMBL
      A6ZME1, B3LLX5, C7GL42, C8ZET6, G2WKD0, M4WH69, N1NXA5
      Conserved Domains (1) summary
      cd08297
      Location:34 → 372
      CAD3; Cinnamyl alcohol dehydrogenases (CAD)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P07246.2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools