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    Lama4 laminin subunit alpha 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 309816, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Lama4provided by RGD
    Official Full Name
    laminin subunit alpha 4provided by RGD
    Primary source
    RGD:1560062
    See related
    EnsemblRapid:ENSRNOG00000000599 AllianceGenome:RGD:1560062
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1560062
    Summary
    Predicted to enable signaling receptor binding activity. Predicted to be involved in negative regulation of cold-induced thermogenesis. Predicted to act upstream of or within blood vessel development and brown fat cell differentiation. Predicted to be located in basement membrane. Predicted to be active in neuromuscular junction and synaptic cleft. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 1JJ. Orthologous to human LAMA4 (laminin subunit alpha 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 457.0), Lung (RPKM 292.5) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Lama4 in Genome Data Viewer
    Location:
    20q12
    Exon count:
    38
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (43946898..44087972)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (42392268..42533347)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (44060715..44201966)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA17 Neighboring gene ret finger protein-like 4B Neighboring gene uncharacterized LOC120098940 Neighboring gene M-phase phosphoprotein 6-like Neighboring gene uncharacterized LOC120098941 Neighboring gene family with sequence similarity 229, member B Neighboring gene tubulin, epsilon 1 Neighboring gene cellular communication network factor 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Laminin-8/9 is synthesized by rat glomerular mesangial cells and is required for PDGF-induced mesangial cell migration. Hansen K, et al. Kidney Int, 2003 Jul. PMID 12787401
    2. Deletion of the laminin alpha4 chain leads to impaired microvessel maturation. Thyboll J, et al. Mol Cell Biol, 2002 Feb. PMID 11809810, Free PMC Article
    3. Primary structure, developmental expression, and immunolocalization of the murine laminin alpha4 chain. Iivanainen A, et al. J Biol Chem, 1997 Oct 31. PMID 9346933
    4. The Absence of Laminin α4 in Male Mice Results in Enhanced Energy Expenditure and Increased Beige Subcutaneous Adipose Tissue. Vaicik MK, et al. Endocrinology, 2018 Jan 1. PMID 28973559, Free PMC Article
    5. Early onset photoreceptor abnormalities induced by targeted disruption of the interphotoreceptor retinoid-binding protein gene. Liou GI, et al. J Neurosci, 1998 Jun 15. PMID 9614228, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables signaling receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within blood vessel development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within brown fat cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of cold-induced thermogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cold-induced thermogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in regulation of cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell migration IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of embryonic development IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in basement membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in neuromuscular junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in synaptic cleft ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    laminin subunit alpha-4
    Names
    laminin, alpha 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001309447.1 → NP_001296376.1  laminin subunit alpha-4 precursor

      See identical proteins and their annotated locations for NP_001296376.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000020
      UniProtKB/TrEMBL
      A6KIE5, F1LTF8
      Related
      ENSRNOP00000000737.8, ENSRNOT00000000737.9
      Conserved Domains (7) summary
      smart00282
      Location:853 → 1008
      LamG; Laminin G domain
      cd00055
      Location:187 → 238
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      cd00110
      Location:1483 → 1618
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam06008
      Location:289 → 547
      Laminin_I; Laminin Domain I
      pfam06009
      Location:727 → 854
      Laminin_II; Laminin Domain II
      cl02488
      Location:314 → 523
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl21509
      Location:610 → 798
      ApoLp-III_like; Apolipophorin-III and similar insect proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      43946898..44087972
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001107635.1: Suppressed sequence

      Description
      NM_001107635.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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