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    SOCS5 suppressor of cytokine signaling 5 [ Homo sapiens (human) ]

    Gene ID: 9655, updated on 10-Dec-2024

    Summary

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    Official Symbol
    SOCS5provided by HGNC
    Official Full Name
    suppressor of cytokine signaling 5provided by HGNC
    Primary source
    HGNC:HGNC:16852
    See related
    Ensembl:ENSG00000171150 MIM:607094; AllianceGenome:HGNC:16852
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CIS6; CISH6; Cish5; SOCS-5
    Summary
    The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS) family, also known as STAT-induced STAT inhibitor (SSI) protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The specific function of this protein has not yet been determined. Two alternatively spliced transcript variants encoding an identical protein have been reported. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in ovary (RPKM 13.6), endometrium (RPKM 9.7) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See SOCS5 in Genome Data Viewer
    Location:
    2p21
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (46698937..46763129)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (46703485..46767961)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (46926076..46990268)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11452 Neighboring gene CXXC repeat containing interactor of PDZ3 domain Neighboring gene uncharacterized LOC105374584 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:46908587-46908781 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11453 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11454 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:46926130-46926646 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11456 Neighboring gene Sharpr-MPRA regulatory region 6790 Neighboring gene Sharpr-MPRA regulatory region 14701 Neighboring gene Sharpr-MPRA regulatory region 15480 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:47043065-47043329 Neighboring gene long intergenic non-protein coding RNA 1118 Neighboring gene long intergenic non-protein coding RNA 1119 Neighboring gene uncharacterized LOC107985880 Neighboring gene Sharpr-MPRA regulatory region 12526

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evaluation of SOCS5 mRNA and its association with serum IL-12 levels and rs41379147 SNP in various subsets of allergic disorders: A case control study. Hussain S, et al. Mol Immunol, 2023 Oct. PMID 37672963
    2. [Association of polymorphism Rs6737848 in the Socs5 gene with bronchial asthma]. Saltykova IV, et al. Vestn Ross Akad Med Nauk, 2013. PMID 24340963
    3. Opisthorchis felineus liver fluke invasion is an environmental factor modifying genetic risk of atopic bronchial asthma. Saltykova IV, et al. Acta Trop, 2014 Nov. PMID 25017311
    4. Deregulation of SOCS5 suppresses dendritic cell function in chronic lymphocytic leukemia. Toniolo PA, et al. Oncotarget, 2016 Jul 19. PMID 27317770, Free PMC Article
    5. Epigenetic silencing of SOCS5 potentiates JAK-STAT signaling and progression of T-cell acute lymphoblastic leukemia. Sharma ND, et al. Cancer Sci, 2019 Jun. PMID 30974024, Free PMC Article

    See all (66) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Resistin stimulates PC-3 prostate cancer cell growth through stimulation of SOCS3 and SOCS5 genes.
      Title: Resistin stimulates PC-3 prostate cancer cell growth through stimulation of SOCS3 and SOCS5 genes.
    2. Sequential inspiratory muscle exercise-noninvasive positive pressure ventilation alleviates oxidative stress in COPD by mediating SOCS5/JAK2/STAT3 pathway.
      Title: Sequential inspiratory muscle exercise-noninvasive positive pressure ventilation alleviates oxidative stress in COPD by mediating SOCS5/JAK2/STAT3 pathway.
    3. Evaluation of SOCS5 mRNA and its association with serum IL-12 levels and rs41379147 SNP in various subsets of allergic disorders: A case control study.
      Title: Evaluation of SOCS5 mRNA and its association with serum IL-12 levels and rs41379147 SNP in various subsets of allergic disorders: A case control study.
    4. SOCS5 contributes to temozolomide resistance in glioblastoma by regulating Bcl-2-mediated autophagy.
      Title: SOCS5 contributes to temozolomide resistance in glioblastoma by regulating Bcl-2-mediated autophagy.
    5. Inhibition of microRNA-448 suppresses CD4(+) T cell inflammatory activation via up-regulating suppressor of cytokine signaling 5 in systemic lupus erythematosus.
      Title: Inhibition of microRNA-448 suppresses CD4(+) T cell inflammatory activation via up-regulating suppressor of cytokine signaling 5 in systemic lupus erythematosus.
    6. LncRNA DHRS4-AS1 ameliorates hepatocellular carcinoma by suppressing proliferation and promoting apoptosis via miR-522-3p/SOCS5 axis.
      Title: LncRNA DHRS4-AS1 ameliorates hepatocellular carcinoma by suppressing proliferation and promoting apoptosis via miR-522-3p/SOCS5 axis.
    7. Long non-coding RNA HCG11 sponging miR-522-3p inhibits the tumorigenesis of non-small cell lung cancer by upregulating SOCS5.
      Title: Long non-coding RNA HCG11 sponging miR-522-3p inhibits the tumorigenesis of non-small cell lung cancer by upregulating SOCS5.
    8. LncRNA CASC2 inhibits cell proliferation, metastasis and EMT through miR-18a/SOCS5 axis in cholangiocarcinoma.
      Title: LncRNA CASC2 inhibits cell proliferation, metastasis and EMT through miR-18a/SOCS5 axis in cholangiocarcinoma.
    9. lncRNA HAND2-AS1 Inhibits Liver Cancer Cell Proliferation and Migration by Upregulating SOCS5 to Inactivate the JAK-STAT Pathway.
      Title: lncRNA HAND2-AS1 Inhibits Liver Cancer Cell Proliferation and Migration by Upregulating SOCS5 to Inactivate the JAK-STAT Pathway.
    10. MicroRNA-301a promotes pancreatic cancer invasion and metastasis through the JAK/STAT3 signaling pathway by targeting SOCS5.
      Title: MicroRNA-301a promotes pancreatic cancer invasion and metastasis through the JAK/STAT3 signaling pathway by targeting SOCS5.
    Submit: New GeneRIF Correction See all GeneRIFs (33)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Gene-alcohol interactions identify several novel blood pressure loci including a promising locus near SLC16A9.
    EBI GWAS Catalog
    Genome-wide association study of smoking behaviours in patients with COPD.
    EBI GWAS Catalog
    Hundreds of variants clustered in genomic loci and biological pathways affect human height.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0671

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables epidermal growth factor receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables receptor tyrosine kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell surface receptor signaling pathway via JAK-STAT IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to low-density lipoprotein particle stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cytokine-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cytokine-mediated signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in epidermal growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of T-helper 2 cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of epidermal growth factor-activated receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of interleukin-6 production IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of monocyte chemotactic protein-1 production IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of signal transduction NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of T-helper 1 cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vascular endothelial cell response to fluid shear stress IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    suppressor of cytokine signaling 5
    Names
    CIS-6
    cytokine-inducible SH2 protein 6
    cytokine-inducible SH2-containing protein 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_014011.5 → NP_054730.1  suppressor of cytokine signaling 5

      See identical proteins and their annotated locations for NP_054730.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 2. Both variants encode the same protein.
      Source sequence(s)
      AB014571, AC020604, AI433294
      Consensus CDS
      CCDS1830.1
      UniProtKB/Swiss-Prot
      O75159, Q53SD4, Q8IYZ4
      UniProtKB/TrEMBL
      B4DL10
      Related
      ENSP00000305133.5, ENST00000306503.5
      Conserved Domains (3) summary
      cd03739
      Location:479 → 534
      SOCS_SOCS5; SOCS (suppressors of cytokine signaling) box of SOCS5-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS5 inhibits Th2 differentiation by inhibiting ...
      pfam12610
      Location:146 → 195
      SOCS; Suppressor of cytokine signalling
      cl15255
      Location:370 → 470
      SH2; Src homology 2 (SH2) domain

    2. NM_144949.3 → NP_659198.1  suppressor of cytokine signaling 5

      See identical proteins and their annotated locations for NP_659198.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants encode the same protein.
      Source sequence(s)
      AB014571, AC020604, AF073958, AI433294
      Consensus CDS
      CCDS1830.1
      UniProtKB/Swiss-Prot
      O75159, Q53SD4, Q8IYZ4
      UniProtKB/TrEMBL
      B4DL10
      Related
      ENSP00000378330.2, ENST00000394861.3
      Conserved Domains (3) summary
      cd03739
      Location:479 → 534
      SOCS_SOCS5; SOCS (suppressors of cytokine signaling) box of SOCS5-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS5 inhibits Th2 differentiation by inhibiting ...
      pfam12610
      Location:146 → 195
      SOCS; Suppressor of cytokine signalling
      cl15255
      Location:370 → 470
      SH2; Src homology 2 (SH2) domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      46698937..46763129
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      46703485..46767961
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O75159.1 GenPept UniProtKB/Swiss-Prot:O75159

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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