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    BSG basigin (Ok blood group) [ Homo sapiens (human) ]

    Gene ID: 682, updated on 10-Dec-2024

    Summary

    Official Symbol
    BSGprovided by HGNC
    Official Full Name
    basigin (Ok blood group)provided by HGNC
    Primary source
    HGNC:HGNC:1116
    See related
    Ensembl:ENSG00000172270 MIM:109480; AllianceGenome:HGNC:1116
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    OK; 5F7; TCSF; CD147; EMPRIN; HAb18G; EMMPRIN
    Summary
    The protein encoded by this gene, basigin, is a plasma membrane protein that is important in spermatogenesis, embryo implantation, neural network formation, and tumor progression. Basigin is also a member of the immunoglobulin superfamily, ubiquitously expressed in various tissues. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2020]
    Expression
    Ubiquitous expression in heart (RPKM 230.6), colon (RPKM 194.1) and 25 other tissues See more
    Orthologs
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    Genomic context

    See BSG in Genome Data Viewer
    Location:
    19p13.3
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (571283..583493)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (525174..537384)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (571283..583493)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:531801-532457 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9605 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13559 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13560 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:534117-534693 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:534694-535269 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13562 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13563 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:535719-535880 Neighboring gene cell division cycle 34, ubiqiutin conjugating enzyme Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:543421-544066 Neighboring gene granzyme M Neighboring gene CRISPRi-validated cis-regulatory element chr19.73 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:570844-571416 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13564 Neighboring gene BSG antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9606 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9607 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:583377-583939 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:583940-584501 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9608 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:588071-588650 Neighboring gene Rho GTPase activating protein 33 pseudogene Neighboring gene hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2 Neighboring gene MPRA-validated peak3211 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9609 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9610 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13565 Neighboring gene uncharacterized LOC107987266 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13566 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:613339-613520

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp160, precursor env The functional interaction between CD98 and CD147 is involved in the regulation of HIV-1 gp160-mediated cell fusion PubMed
    Tat tat Application of HIV-1 Tat transmembrane transport peptide to cells induces PKN1 gene and slightly represses two genes, ZCD1 and BSG PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables D-mannose binding  
    enables cadherin binding PubMed 
    enables cell-cell adhesion mediator activity  
    enables protein binding PubMed 
    enables signaling receptor activity PubMed 
    enables virus receptor activity  
    enables virus receptor activity PubMed 
    Items 1 - 25 of 26
    Process Evidence Code Pubs
    involved_in angiogenesis  
    involved_in axon guidance  
    involved_in cell surface receptor signaling pathway PubMed 
    involved_in decidualization  
    involved_in dendrite self-avoidance  
    involved_in embryo implantation  
    involved_in endothelial tube morphogenesis PubMed 
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules  
    involved_in neural retina development  
    involved_in neutrophil chemotaxis PubMed 
    involved_in odontogenesis of dentin-containing tooth  
    involved_in photoreceptor cell maintenance PubMed 
    involved_in positive regulation of endothelial cell migration PubMed 
    involved_in positive regulation of interleukin-6 production PubMed 
    involved_in positive regulation of matrix metallopeptidase secretion PubMed 
    involved_in positive regulation of matrix metallopeptidase secretion PubMed 
    involved_in positive regulation of vascular endothelial growth factor production PubMed 
    involved_in positive regulation of vascular endothelial growth factor production PubMed 
    involved_in positive regulation of viral entry into host cell PubMed 
    involved_in positive regulation of viral entry into host cell PubMed 
    acts_upstream_of_or_within protein localization to plasma membrane PubMed 
    involved_in protein localization to plasma membrane  
    involved_in response to cAMP  
    involved_in response to mercury ion  
    involved_in response to peptide hormone  
    involved_in symbiont entry into host cell  
    Items 1 - 25 of 26
    Items 1 - 20 of 24
    Component Evidence Code Pubs
    located_in Golgi membrane  
    located_in acrosomal membrane  
    is_active_in axon  
    located_in basolateral plasma membrane  
    located_in endoplasmic reticulum membrane PubMed 
    located_in endoplasmic reticulum membrane  
    located_in endosome PubMed 
    located_in endosome  
    located_in extracellular exosome PubMed 
    located_in focal adhesion PubMed 
    located_in intracellular membrane-bounded organelle  
    located_in melanosome  
    located_in membrane PubMed 
    located_in mitochondrion PubMed 
    located_in photoreceptor inner segment  
    located_in photoreceptor inner segment  
    located_in photoreceptor outer segment  
    located_in photoreceptor outer segment  
    located_in plasma membrane PubMed 
    is_active_in plasma membrane  
    located_in plasma membrane PubMed 
    located_in plasma membrane  
    located_in plasma membrane  
    located_in sarcolemma  
    Items 1 - 20 of 24

    General protein information

    Preferred Names
    basigin
    Names
    OK blood group antigen
    collagenase stimulatory factor
    extracellular matrix metalloproteinase inducer
    hepatoma-associated antigen
    leukocyte activation antigen M6
    tumor cell-derived collagenase stimulatory factor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_007468.1 RefSeqGene

      Range
      6272..17169
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_816

    mRNA and Protein(s)

    1. NM_001322243.2 → NP_001309172.1  basigin isoform 2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5), as well as variant 2, encodes isoform 2.
      Source sequence(s)
      AC009005, CB153773, GU557064
      Consensus CDS
      CCDS12034.1
      UniProtKB/TrEMBL
      A0A7P0TA85, A0A7P0TB04, Q54A51
      Conserved Domains (1) summary
      smart00409
      Location:112 → 202
      IG; Immunoglobulin
    2. NM_001728.4 → NP_001719.2  basigin isoform 1 precursor

      See identical proteins and their annotated locations for NP_001719.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AY358113, GU557064
      Consensus CDS
      CCDS12033.1
      UniProtKB/Swiss-Prot
      A6NJW1, D3YLG5, P35613, Q7Z796, Q8IZL7
      UniProtKB/TrEMBL
      B4DNE1
      Related
      ENSP00000333769.3, ENST00000333511.9
      Conserved Domains (2) summary
      smart00409
      Location:228 → 318
      IG; Immunoglobulin
      cd20940
      Location:23 → 138
      Ig0_BSG1; Immunoglobulin-like Ig0 domain of basigin-1 (BSG1) and similar proteins
    3. NM_198589.3 → NP_940991.1  basigin isoform 2 precursor

      See identical proteins and their annotated locations for NP_940991.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1. Variants 2 and 5 both encode the same isoform (2).
      Source sequence(s)
      AB085790, GU557064
      Consensus CDS
      CCDS12034.1
      UniProtKB/TrEMBL
      A0A7P0TA85, A0A7P0TB04, Q54A51
      Related
      ENSP00000343809.4, ENST00000353555.9
      Conserved Domains (1) summary
      smart00409
      Location:112 → 202
      IG; Immunoglobulin
    4. NM_198590.3 → NP_940992.1  basigin isoform 3

      See identical proteins and their annotated locations for NP_940992.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      DA007913, GU557064
      Consensus CDS
      CCDS58635.1
      UniProtKB/TrEMBL
      A0A087WUV8
      Related
      ENSP00000473664.1, ENST00000545507.6
      Conserved Domains (2) summary
      smart00410
      Location:19 → 109
      IG_like; Immunoglobulin like
      cd00096
      Location:11 → 15
      Ig; Ig strand A [structural motif]
    5. NM_198591.4 → NP_940993.2  basigin isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC009005, GU557065
      Consensus CDS
      CCDS58635.1
      UniProtKB/TrEMBL
      A0A087WUV8
      Related
      ENSP00000344707.4, ENST00000346916.9
      Conserved Domains (2) summary
      smart00410
      Location:19 → 109
      IG_like; Immunoglobulin like
      cd00096
      Location:11 → 15
      Ig; Ig strand A [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      571283..583493
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      525174..537384
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054321844.1 → XP_054177819.1  basigin isoform X1

      UniProtKB/Swiss-Prot
      A6NJW1, D3YLG5, P35613, Q7Z796, Q8IZL7
      UniProtKB/TrEMBL
      B4DNE1
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