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    RNF11 ring finger protein 11 [ Homo sapiens (human) ]

    Gene ID: 26994, updated on 10-Dec-2024

    Summary

    Official Symbol
    RNF11provided by HGNC
    Official Full Name
    ring finger protein 11provided by HGNC
    Primary source
    HGNC:HGNC:10056
    See related
    Ensembl:ENSG00000123091 MIM:612598; AllianceGenome:HGNC:10056
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CGI-123; SID1669
    Summary
    The protein encoded by this gene contains a RING-H2 finger motif, which is known to be important for protein-protein interactions. The expression of this gene has been shown to be induced by mutant RET proteins (MEN2A/MEN2B). The germline mutations in RET gene are known to be responsible for the development of multiple endocrine neoplasia (MEN). [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in brain (RPKM 65.4), thyroid (RPKM 55.4) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See RNF11 in Genome Data Viewer
    Location:
    1p32.3
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (51236273..51273447)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (51116181..51153351)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (51701945..51739119)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene mitochondrial import receptor subunit TOM5 homolog Neighboring gene long intergenic non-protein coding RNA 1562 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 871 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 872 Neighboring gene small nucleolar RNA U13 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 873 Neighboring gene Sharpr-MPRA regulatory region 6511 Neighboring gene ribosomal protein S2 pseudogene 8 Neighboring gene Sharpr-MPRA regulatory region 5693 Neighboring gene uncharacterized LOC124904177 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:51763453-51764095 Neighboring gene tetratricopeptide repeat domain 39A Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 874 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:51777239-51777740 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:51777741-51778240 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:51778629-51779444 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 875 Neighboring gene TTC39A antisense RNA 1

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    BioGRID CRISPR Screen Phenotypes (47 hits/1312 screens)

    EBI GWAS Catalog

    Description
    Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction.
    EBI GWAS Catalog

    Interactions

    General gene information

    Clone Names

    • MGC51169

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding PubMed 
    enables protein binding PubMed 
    enables ubiquitin protein ligase activity  
    enables ubiquitin protein ligase activity PubMed 
    enables zinc ion binding PubMed 
    Component Evidence Code Pubs
    located_in early endosome  
    located_in extracellular exosome PubMed 
    located_in nucleus  
    located_in recycling endosome  
    part_of ubiquitin ligase complex  
    part_of ubiquitin ligase complex PubMed 

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_014372.5 → NP_055187.1  RING finger protein 11

      See identical proteins and their annotated locations for NP_055187.1

      Status: REVIEWED

      Source sequence(s)
      AA224090, BC020964, BC036670, BC047654, DB265274, DB564333
      Consensus CDS
      CCDS556.1
      UniProtKB/Swiss-Prot
      A8KAI2, Q5T7R8, Q9Y3C5
      Related
      ENSP00000242719.3, ENST00000242719.4
      Conserved Domains (1) summary
      cd16468
      Location:98 → 140
      RING-H2_RNF11; RING finger, H2 subclass, found in RING finger protein 11 (RNF11) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      51236273..51273447
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      51116181..51153351
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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