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    TCF3 transcription factor 3 [ Homo sapiens (human) ]

    Gene ID: 6929, updated on 10-Dec-2024

    Summary

    Official Symbol
    TCF3provided by HGNC
    Official Full Name
    transcription factor 3provided by HGNC
    Primary source
    HGNC:HGNC:11633
    See related
    Ensembl:ENSG00000071564 MIM:147141; AllianceGenome:HGNC:11633
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    E2A; E47; p75; AGM8; ITF1; VDIR; AGM8A; AGM8B; TCF-3; bHLHb21
    Summary
    This gene encodes a member of the E protein (class I) family of helix-loop-helix transcription factors. E proteins activate transcription by binding to regulatory E-box sequences on target genes as heterodimers or homodimers, and are inhibited by heterodimerization with inhibitor of DNA-binding (class IV) helix-loop-helix proteins. E proteins play a critical role in lymphopoiesis, and the encoded protein is required for B and T lymphocyte development. Deletion of this gene or diminished activity of the encoded protein may play a role in lymphoid malignancies. This gene is also involved in several chromosomal translocations that are associated with lymphoid malignancies including pre-B-cell acute lymphoblastic leukemia (t(1;19), with PBX1), childhood leukemia (t(19;19), with TFPT) and acute leukemia (t(12;19), with ZNF384). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, Sep 2011]
    Expression
    Broad expression in testis (RPKM 16.2), lymph node (RPKM 12.8) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See TCF3 in Genome Data Viewer
    Location:
    19p13.3
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (1609292..1652615, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (1580117..1623781, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (1609291..1652614, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:1584307-1584918 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:1584919-1585529 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:1590888-1591877 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9730 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9731 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9732 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9733 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13615 Neighboring gene methyl-CpG binding domain protein 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9734 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9735 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13616 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:1606417-1607038 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13617 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13618 Neighboring gene ubiquinol-cytochrome c reductase, complex III subunit XI Neighboring gene RNA, U6 small nuclear 1223, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:1626353-1626854 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13619 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13620 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13621 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:1649155-1649654 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:1651633-1651855 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9738 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9739 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9740 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13622 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13623 Neighboring gene MPRA-validated peak3223 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:1667070-1667570 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9741 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:1668943-1669693 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:1672373-1672900 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:1690448-1690998 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:1690999-1691550 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:1722988-1723177 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:1725449-1725948 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:1743285-1743784 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:1743951-1744173 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr19:1747113-1748312 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:1748390-1748908 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:1757201-1757790 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:1757791-1758378 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:1762447-1762983 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:1765801-1766322 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:1767617-1768311 Neighboring gene one cut homeobox 3 Neighboring gene uncharacterized LOC101928543 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13625 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:1789295-1790117 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:1795609-1796421 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:1796422-1797233 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:1799861-1800031 Neighboring gene ATPase phospholipid transporting 8B3 Neighboring gene MPRA-validated peak3225 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:1811783-1812528

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    BioGRID CRISPR Screen Phenotypes (64 hits/1300 screens)

    Associated conditions

    Description Tests
    Agammaglobulinemia 8, autosomal dominant
    MedGen: C4310786 OMIM: 616941 GeneReviews: Not available
    Compare labs
    Agammaglobulinemia 8b, autosomal recessive
    MedGen: C5676958 OMIM: 619824 GeneReviews: Not available
    Compare labs

    EBI GWAS Catalog

    Description
    A meta-analysis of Hodgkin lymphoma reveals 19p13.3 TCF3 as a novel susceptibility locus.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat Interaction of TFIID with the HIV-1 LTR, and therefore presumably HIV-1 Tat protein, is primarily dependent on the LTR TATA element and may also be stabilized or regulated by flanking E box motifs and basic helix-loop-helix proteins such as AP-4 and E47 PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • MGC129647, MGC129648

    Gene Ontology Provided by GOA

    Items 1 - 25 of 26
    Function Evidence Code Pubs
    contributes_to DNA binding PubMed 
    enables DNA binding PubMed 
    enables DNA-binding transcription activator activity, RNA polymerase II-specific PubMed 
    enables DNA-binding transcription factor activity PubMed 
    enables DNA-binding transcription factor activity PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific  
    enables DNA-binding transcription factor binding PubMed 
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific PubMed 
    contributes_to E-box binding PubMed 
    enables E-box binding PubMed 
    contributes_to E-box binding PubMed 
    contributes_to E-box binding  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding PubMed 
    enables RNA polymerase II-specific DNA-binding transcription factor binding PubMed 
    enables bHLH transcription factor binding PubMed 
    enables cis-regulatory region sequence-specific DNA binding PubMed 
    enables mitogen-activated protein kinase kinase kinase binding PubMed 
    enables protein binding PubMed 
    enables protein heterodimerization activity PubMed 
    enables protein heterodimerization activity PubMed 
    enables protein homodimerization activity PubMed 
    enables protein homodimerization activity PubMed 
    contributes_to transcription cis-regulatory region binding PubMed 
    enables vitamin D response element binding PubMed 
    Items 1 - 25 of 26
    Process Evidence Code Pubs
    involved_in B cell differentiation PubMed 
    involved_in B cell lineage commitment PubMed 
    involved_in B cell lineage commitment PubMed 
    involved_in immunoglobulin V(D)J recombination  
    acts_upstream_of_or_within immunoglobulin V(D)J recombination PubMed 
    involved_in negative regulation of transcription by RNA polymerase II PubMed 
    involved_in nervous system development  
    involved_in positive regulation of B cell proliferation PubMed 
    involved_in positive regulation of DNA-binding transcription factor activity PubMed 
    involved_in positive regulation of DNA-templated transcription PubMed 
    involved_in positive regulation of cell cycle PubMed 
    involved_in positive regulation of neuron differentiation  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II PubMed 
    involved_in positive regulation of transcription by RNA polymerase II PubMed 
    involved_in positive regulation of transcription by RNA polymerase II PubMed 
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in regulation of DNA-templated transcription PubMed 
    involved_in regulation of G1/S transition of mitotic cell cycle PubMed 
    involved_in regulation of transcription by RNA polymerase II  
    Component Evidence Code Pubs
    part_of RNA polymerase II transcription regulator complex PubMed 
    located_in chromatin  
    located_in chromatin PubMed 
    located_in chromatin  
    located_in cytoplasm PubMed 
    located_in euchromatin PubMed 
    located_in nucleoplasm  
    located_in nucleoplasm  
    located_in nucleus PubMed 
    located_in nucleus PubMed 
    part_of protein-containing complex PubMed 
    part_of transcription regulator complex  
    part_of transcription regulator complex PubMed 

    General protein information

    Preferred Names
    transcription factor E2-alpha
    Names
    E2A-HLF fusion transcript protein
    NOL1-TCF3 fusion
    VDR interacting repressor
    class B basic helix-loop-helix protein 21
    helix-loop-helix protein HE47
    immunoglobulin transcription factor 1
    kappa-E2-binding factor
    negative vitamin D response element-binding protein
    transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)
    transcription factor ITF-1
    vitamin D receptor-interacting repressor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029953.2 RefSeqGene

      Range
      4932..48255
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_1325

    mRNA and Protein(s)

    1. NM_001136139.4 → NP_001129611.1  transcription factor E2-alpha isoform E47

      See identical proteins and their annotated locations for NP_001129611.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR, lacks an exon and includes an alternate exon in the 3' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (E47, also known as Pan-1) is shorter than isoform E12. Variants 2 and 4 encode the same isoform (E47).
      Source sequence(s)
      AC005321, AC006274, AW028755, BG284440, BU528547, CD516687, CD674814, KC877695, M24404
      Consensus CDS
      CCDS45899.1
      UniProtKB/TrEMBL
      X6REB3
      Related
      ENSP00000468487.1, ENST00000588136.7
      Conserved Domains (1) summary
      cd18943
      Location:538 → 611
      bHLH_E-protein_E47-like; basic helix-loop-helix (bHLH) domain found in transcription factor E47 and similar proteins
    2. NM_001351778.2 → NP_001338707.1  transcription factor E2-alpha isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site in the central coding region, and contains an alternate splice structure in the 3' region, resulting in differences in the 3' UTR. The encoded isoform (3) has the same N- and C-termini, but is one aa shorter than isoform 1.
      Source sequence(s)
      AA251176, AC006274, AW968445, KC877695, M31222
      UniProtKB/TrEMBL
      Q6PJU3
      Conserved Domains (2) summary
      smart00353
      Location:554 → 607
      HLH; helix loop helix domain
      pfam03985
      Location:495 → 549
      Paf1; Paf1
    3. NM_001351779.2 → NP_001338708.1  transcription factor E2-alpha isoform E47

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) contains an alternate penultimate exon compared to variant 1. The encoded isoform (E47, also known as Pan-1) is shorter than isoform E12. Variants 2 and 4 encode the same isoform (E47).
      Source sequence(s)
      AC005321, AC006274, AW028755, BG284440, KC877695, M24404, M31222
      Consensus CDS
      CCDS45899.1
      UniProtKB/TrEMBL
      X6REB3
      Conserved Domains (1) summary
      cd18943
      Location:538 → 611
      bHLH_E-protein_E47-like; basic helix-loop-helix (bHLH) domain found in transcription factor E47 and similar proteins
    4. NM_003200.5 → NP_003191.1  transcription factor E2-alpha isoform E12

      See identical proteins and their annotated locations for NP_003191.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (E12). This isoform is also known as Pan-2.
      Source sequence(s)
      AC005321, AC006274, KC877695, M31222
      Consensus CDS
      CCDS12074.1
      UniProtKB/Swiss-Prot
      P15883, P15923, Q14208, Q14635, Q14636, Q2TB39, Q2TB40, Q9UPI9
      UniProtKB/TrEMBL
      Q6PJU3
      Related
      ENSP00000262965.5, ENST00000262965.12
      Conserved Domains (2) summary
      smart00353
      Location:555 → 608
      HLH; helix loop helix domain
      pfam03985
      Location:496 → 549
      Paf1; Paf1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      1609292..1652615 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047439298.1 → XP_047295254.1  transcription factor E2-alpha isoform X12

      UniProtKB/TrEMBL
      U5LXR9
    2. XM_047439297.1 → XP_047295253.1  transcription factor E2-alpha isoform X10

      UniProtKB/TrEMBL
      U5LXR9
    3. XM_047439296.1 → XP_047295252.1  transcription factor E2-alpha isoform X11

      UniProtKB/TrEMBL
      U5LXR9
      Related
      ENSP00000378813.3, ENST00000395423.7
    4. XM_047439294.1 → XP_047295250.1  transcription factor E2-alpha isoform X11

      UniProtKB/TrEMBL
      U5LXR9
    5. XM_047439290.1 → XP_047295246.1  transcription factor E2-alpha isoform X9

      UniProtKB/TrEMBL
      X6REB3
    6. XM_047439286.1 → XP_047295242.1  transcription factor E2-alpha isoform X8

      UniProtKB/TrEMBL
      X6REB3
    7. XM_011528226.3 → XP_011526528.1  transcription factor E2-alpha isoform X8

      UniProtKB/TrEMBL
      X6REB3
      Conserved Domains (1) summary
      smart00353
      Location:551 → 604
      HLH; helix loop helix domain
    8. XM_047439279.1 → XP_047295235.1  transcription factor E2-alpha isoform X5

      UniProtKB/TrEMBL
      Q6PJU3
    9. XM_047439285.1 → XP_047295241.1  transcription factor E2-alpha isoform X7

      UniProtKB/TrEMBL
      X6REB3
    10. XM_011528225.3 → XP_011526527.1  transcription factor E2-alpha isoform X7

      UniProtKB/TrEMBL
      X6REB3
      Conserved Domains (1) summary
      smart00353
      Location:551 → 604
      HLH; helix loop helix domain
    11. XM_047439284.1 → XP_047295240.1  transcription factor E2-alpha isoform X6

      UniProtKB/TrEMBL
      X6REB3
    12. XM_047439283.1 → XP_047295239.1  transcription factor E2-alpha isoform X6

      UniProtKB/TrEMBL
      X6REB3
    13. XM_047439278.1 → XP_047295234.1  transcription factor E2-alpha isoform X4

      UniProtKB/Swiss-Prot
      P15883, P15923, Q14208, Q14635, Q14636, Q2TB39, Q2TB40, Q9UPI9
      UniProtKB/TrEMBL
      Q6PJU3
    14. XM_047439277.1 → XP_047295233.1  transcription factor E2-alpha isoform X4

      UniProtKB/Swiss-Prot
      P15883, P15923, Q14208, Q14635, Q14636, Q2TB39, Q2TB40, Q9UPI9
      UniProtKB/TrEMBL
      Q6PJU3
    15. XM_017027181.2 → XP_016882670.1  transcription factor E2-alpha isoform X4

      UniProtKB/Swiss-Prot
      P15883, P15923, Q14208, Q14635, Q14636, Q2TB39, Q2TB40, Q9UPI9
      UniProtKB/TrEMBL
      Q6PJU3
      Conserved Domains (2) summary
      smart00353
      Location:555 → 608
      HLH; helix loop helix domain
      pfam03985
      Location:496 → 549
      Paf1; Paf1
    16. XM_047439261.1 → XP_047295217.1  transcription factor E2-alpha isoform X2

      UniProtKB/TrEMBL
      X6REB3
    17. XM_017027178.2 → XP_016882667.1  transcription factor E2-alpha isoform X3

      UniProtKB/TrEMBL
      X6REB3
      Conserved Domains (1) summary
      smart00353
      Location:581 → 634
      HLH; helix loop helix domain
    18. XM_047439262.1 → XP_047295218.1  transcription factor E2-alpha isoform X3

      UniProtKB/TrEMBL
      X6REB3
      Related
      ENSP00000396363.3, ENST00000453954.6
    19. XM_006722855.5 → XP_006722918.1  transcription factor E2-alpha isoform X3

      See identical proteins and their annotated locations for XP_006722918.1

      UniProtKB/TrEMBL
      X6REB3
      Conserved Domains (1) summary
      smart00353
      Location:581 → 634
      HLH; helix loop helix domain
    20. XM_047439259.1 → XP_047295215.1  transcription factor E2-alpha isoform X1

      UniProtKB/TrEMBL
      X6REB3
    21. XM_047439260.1 → XP_047295216.1  transcription factor E2-alpha isoform X1

      UniProtKB/TrEMBL
      X6REB3
    22. XM_047439295.1 → XP_047295251.1  transcription factor E2-alpha isoform X11

      UniProtKB/TrEMBL
      U5LXR9
    23. XM_047439291.1 → XP_047295247.1  transcription factor E2-alpha isoform X9

      UniProtKB/TrEMBL
      X6REB3
    24. XM_047439280.1 → XP_047295236.1  transcription factor E2-alpha isoform X5

      UniProtKB/TrEMBL
      Q6PJU3
    25. XM_047439289.1 → XP_047295245.1  transcription factor E2-alpha isoform X7

      UniProtKB/TrEMBL
      X6REB3
    26. XM_047439287.1 → XP_047295243.1  transcription factor E2-alpha isoform X7

      UniProtKB/TrEMBL
      X6REB3
    27. XM_047439282.1 → XP_047295238.1  transcription factor E2-alpha isoform X6

      UniProtKB/TrEMBL
      X6REB3
    28. XM_047439281.1 → XP_047295237.1  transcription factor E2-alpha isoform X6

      UniProtKB/TrEMBL
      X6REB3
    29. XM_047439276.1 → XP_047295232.1  transcription factor E2-alpha isoform X4

      UniProtKB/Swiss-Prot
      P15883, P15923, Q14208, Q14635, Q14636, Q2TB39, Q2TB40, Q9UPI9
      UniProtKB/TrEMBL
      Q6PJU3
    30. XM_047439258.1 → XP_047295214.1  transcription factor E2-alpha isoform X1

      UniProtKB/TrEMBL
      X6REB3
    31. XM_047439293.1 → XP_047295249.1  transcription factor E2-alpha isoform X10

      UniProtKB/TrEMBL
      U5LXR9
    32. XM_047439292.1 → XP_047295248.1  transcription factor E2-alpha isoform X10

      UniProtKB/TrEMBL
      U5LXR9
    33. XM_047439275.1 → XP_047295231.1  transcription factor E2-alpha isoform X9

      UniProtKB/TrEMBL
      X6REB3
    34. XM_047439274.1 → XP_047295230.1  transcription factor E2-alpha isoform X8

      UniProtKB/TrEMBL
      X6REB3
    35. XM_047439273.1 → XP_047295229.1  transcription factor E2-alpha isoform X8

      UniProtKB/TrEMBL
      X6REB3
    36. XM_047439271.1 → XP_047295227.1  transcription factor E2-alpha isoform X8

      UniProtKB/TrEMBL
      X6REB3
    37. XM_047439267.1 → XP_047295223.1  transcription factor E2-alpha isoform X5

      UniProtKB/TrEMBL
      Q6PJU3
    38. XM_047439266.1 → XP_047295222.1  transcription factor E2-alpha isoform X5

      UniProtKB/TrEMBL
      Q6PJU3
    39. XM_047439288.1 → XP_047295244.1  transcription factor E2-alpha isoform X7

      UniProtKB/TrEMBL
      X6REB3
    40. XM_047439272.1 → XP_047295228.1  transcription factor E2-alpha isoform X7

      UniProtKB/TrEMBL
      X6REB3
    41. XM_047439270.1 → XP_047295226.1  transcription factor E2-alpha isoform X7

      UniProtKB/TrEMBL
      X6REB3
    42. XM_047439269.1 → XP_047295225.1  transcription factor E2-alpha isoform X6

      UniProtKB/TrEMBL
      X6REB3
    43. XM_047439268.1 → XP_047295224.1  transcription factor E2-alpha isoform X6

      UniProtKB/TrEMBL
      X6REB3
    44. XM_047439265.1 → XP_047295221.1  transcription factor E2-alpha isoform X4

      UniProtKB/Swiss-Prot
      P15883, P15923, Q14208, Q14635, Q14636, Q2TB39, Q2TB40, Q9UPI9
      UniProtKB/TrEMBL
      Q6PJU3
    45. XM_047439264.1 → XP_047295220.1  transcription factor E2-alpha isoform X4

      UniProtKB/Swiss-Prot
      P15883, P15923, Q14208, Q14635, Q14636, Q2TB39, Q2TB40, Q9UPI9
      UniProtKB/TrEMBL
      Q6PJU3
    46. XM_047439263.1 → XP_047295219.1  transcription factor E2-alpha isoform X4

      UniProtKB/Swiss-Prot
      P15883, P15923, Q14208, Q14635, Q14636, Q2TB39, Q2TB40, Q9UPI9
      UniProtKB/TrEMBL
      Q6PJU3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      1580117..1623781 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054321896.1 → XP_054177871.1  transcription factor E2-alpha isoform X12

      UniProtKB/TrEMBL
      U5LXR9
    2. XM_054321895.1 → XP_054177870.1  transcription factor E2-alpha isoform X10

      UniProtKB/TrEMBL
      U5LXR9
    3. XM_054321894.1 → XP_054177869.1  transcription factor E2-alpha isoform X11

      UniProtKB/TrEMBL
      U5LXR9
    4. XM_054321892.1 → XP_054177867.1  transcription factor E2-alpha isoform X11

      UniProtKB/TrEMBL
      U5LXR9
    5. XM_054321888.1 → XP_054177863.1  transcription factor E2-alpha isoform X9

      UniProtKB/TrEMBL
      X6REB3
    6. XM_054321883.1 → XP_054177858.1  transcription factor E2-alpha isoform X8

      UniProtKB/TrEMBL
      X6REB3
    7. XM_054321880.1 → XP_054177855.1  transcription factor E2-alpha isoform X8

      UniProtKB/TrEMBL
      X6REB3
    8. XM_054321869.1 → XP_054177844.1  transcription factor E2-alpha isoform X5

      UniProtKB/TrEMBL
      Q6PJU3
    9. XM_054321882.1 → XP_054177857.1  transcription factor E2-alpha isoform X7

      UniProtKB/TrEMBL
      X6REB3
    10. XM_054321878.1 → XP_054177853.1  transcription factor E2-alpha isoform X7

      UniProtKB/TrEMBL
      X6REB3
    11. XM_054321877.1 → XP_054177852.1  transcription factor E2-alpha isoform X6

      UniProtKB/TrEMBL
      X6REB3
    12. XM_054321875.1 → XP_054177850.1  transcription factor E2-alpha isoform X6

      UniProtKB/TrEMBL
      X6REB3
    13. XM_054321868.1 → XP_054177843.1  transcription factor E2-alpha isoform X4

      UniProtKB/Swiss-Prot
      P15883, P15923, Q14208, Q14635, Q14636, Q2TB39, Q2TB40, Q9UPI9
      UniProtKB/TrEMBL
      Q6PJU3
    14. XM_054321866.1 → XP_054177841.1  transcription factor E2-alpha isoform X4

      UniProtKB/Swiss-Prot
      P15883, P15923, Q14208, Q14635, Q14636, Q2TB39, Q2TB40, Q9UPI9
      UniProtKB/TrEMBL
      Q6PJU3
    15. XM_054321864.1 → XP_054177839.1  transcription factor E2-alpha isoform X4

      UniProtKB/Swiss-Prot
      P15883, P15923, Q14208, Q14635, Q14636, Q2TB39, Q2TB40, Q9UPI9
      UniProtKB/TrEMBL
      Q6PJU3
    16. XM_054321854.1 → XP_054177829.1  transcription factor E2-alpha isoform X2

      UniProtKB/TrEMBL
      X6REB3
    17. XM_054321856.1 → XP_054177831.1  transcription factor E2-alpha isoform X3

      UniProtKB/TrEMBL
      X6REB3
    18. XM_054321857.1 → XP_054177832.1  transcription factor E2-alpha isoform X3

      UniProtKB/TrEMBL
      X6REB3
    19. XM_054321855.1 → XP_054177830.1  transcription factor E2-alpha isoform X3

      UniProtKB/TrEMBL
      X6REB3
    20. XM_054321852.1 → XP_054177827.1  transcription factor E2-alpha isoform X1

      UniProtKB/TrEMBL
      X6REB3
    21. XM_054321853.1 → XP_054177828.1  transcription factor E2-alpha isoform X1

      UniProtKB/TrEMBL
      X6REB3
    22. XM_054321893.1 → XP_054177868.1  transcription factor E2-alpha isoform X11

      UniProtKB/TrEMBL
      U5LXR9
    23. XM_054321889.1 → XP_054177864.1  transcription factor E2-alpha isoform X9

      UniProtKB/TrEMBL
      X6REB3
    24. XM_054321871.1 → XP_054177846.1  transcription factor E2-alpha isoform X5

      UniProtKB/TrEMBL
      Q6PJU3
    25. XM_054321887.1 → XP_054177862.1  transcription factor E2-alpha isoform X7

      UniProtKB/TrEMBL
      X6REB3
    26. XM_054321885.1 → XP_054177860.1  transcription factor E2-alpha isoform X7

      UniProtKB/TrEMBL
      X6REB3
    27. XM_054321873.1 → XP_054177848.1  transcription factor E2-alpha isoform X6

      UniProtKB/TrEMBL
      X6REB3
    28. XM_054321872.1 → XP_054177847.1  transcription factor E2-alpha isoform X6

      UniProtKB/TrEMBL
      X6REB3
    29. XM_054321862.1 → XP_054177837.1  transcription factor E2-alpha isoform X4

      UniProtKB/Swiss-Prot
      P15883, P15923, Q14208, Q14635, Q14636, Q2TB39, Q2TB40, Q9UPI9
      UniProtKB/TrEMBL
      Q6PJU3
    30. XM_054321851.1 → XP_054177826.1  transcription factor E2-alpha isoform X1

      UniProtKB/TrEMBL
      X6REB3
    31. XM_054321886.1 → XP_054177861.1  transcription factor E2-alpha isoform X7

      UniProtKB/TrEMBL
      X6REB3
    32. XM_054321858.1 → XP_054177833.1  transcription factor E2-alpha isoform X5

      UniProtKB/TrEMBL
      Q6PJU3
    33. XM_054321870.1 → XP_054177845.1  transcription factor E2-alpha isoform X5

      UniProtKB/TrEMBL
      Q6PJU3
    34. XM_054321867.1 → XP_054177842.1  transcription factor E2-alpha isoform X4

      UniProtKB/Swiss-Prot
      P15883, P15923, Q14208, Q14635, Q14636, Q2TB39, Q2TB40, Q9UPI9
      UniProtKB/TrEMBL
      Q6PJU3
    35. XM_054321865.1 → XP_054177840.1  transcription factor E2-alpha isoform X4

      UniProtKB/Swiss-Prot
      P15883, P15923, Q14208, Q14635, Q14636, Q2TB39, Q2TB40, Q9UPI9
      UniProtKB/TrEMBL
      Q6PJU3
    36. XM_054321860.1 → XP_054177835.1  transcription factor E2-alpha isoform X8

      UniProtKB/TrEMBL
      X6REB3
    37. XM_054321884.1 → XP_054177859.1  transcription factor E2-alpha isoform X8

      UniProtKB/TrEMBL
      X6REB3
    38. XM_054321881.1 → XP_054177856.1  transcription factor E2-alpha isoform X7

      UniProtKB/TrEMBL
      X6REB3
    39. XM_054321861.1 → XP_054177836.1  transcription factor E2-alpha isoform X9

      UniProtKB/TrEMBL
      X6REB3
    40. XM_054321859.1 → XP_054177834.1  transcription factor E2-alpha isoform X8

      UniProtKB/TrEMBL
      X6REB3
    41. XM_054321879.1 → XP_054177854.1  transcription factor E2-alpha isoform X7

      UniProtKB/TrEMBL
      X6REB3
    42. XM_054321876.1 → XP_054177851.1  transcription factor E2-alpha isoform X6

      UniProtKB/TrEMBL
      X6REB3
    43. XM_054321874.1 → XP_054177849.1  transcription factor E2-alpha isoform X6

      UniProtKB/TrEMBL
      X6REB3
    44. XM_054321863.1 → XP_054177838.1  transcription factor E2-alpha isoform X4

      UniProtKB/Swiss-Prot
      P15883, P15923, Q14208, Q14635, Q14636, Q2TB39, Q2TB40, Q9UPI9
      UniProtKB/TrEMBL
      Q6PJU3
    45. XM_054321891.1 → XP_054177866.1  transcription factor E2-alpha isoform X10

      UniProtKB/TrEMBL
      U5LXR9
    46. XM_054321890.1 → XP_054177865.1  transcription factor E2-alpha isoform X10

      UniProtKB/TrEMBL
      U5LXR9
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