ARMCX3 armadillo repeat containing X-linked 3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ARMCX3provided by HGNC
Official Full Name: armadillo repeat containing X-linked 3provided by HGNC
Primary source: HGNC:HGNC:24065
See related: Ensembl:ENSG00000102401 MIM:300364; AllianceGenome:HGNC:24065
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ALEX3; GASP6; dJ545K15.2
Summary: This gene encodes a member of the ALEX family of proteins which may play a role in tumor suppression. The encoded protein contains a potential N-terminal transmembrane domain and a single Armadillo (arm) repeat. Other proteins containing the arm repeat are involved in development, maintenance of tissue integrity, and tumorigenesis. This gene is closely localized with other family members on the X chromosome. Three transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in adrenal (RPKM 17.0), thyroid (RPKM 15.9) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: Xq22.1

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	X	NC_000023.11 (101623151..101627843)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	X	NC_060947.1 (100067782..100072474)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	X	NC_000023.10 (100878141..100882833)

Chromosome X - NC_000023.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

reduction of Alex3 correlates with the development of non-small cell lung cancer and predicts adverse clinical outcome of non-small cell lung cancer patients. The effect of Alex3 on inhibiting invasion and migration may attribute to upregulation of E-cadherin expression through AKT-Slug pathway inactivation.
Title: Alex3 suppresses non-small cell lung cancer invasion via AKT/Slug/E-cadherin pathway.
The Wnt pathway regulates mitochondrial distribution and dynamics through Alex3 protein degradation.
Title: The non-canonical Wnt/PKC pathway regulates mitochondrial dynamics through degradation of the arm-like domain-containing protein Alex3.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-64837 (e-PCR)
- UniSTS:185134

RH36341 (e-PCR)
- UniSTS:25018

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in axonal transport of mitochondrion	IEA Inferred from Electronic Annotation more info
involved_in mitochondrion organization	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in protein localization	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in axon cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HTP more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: armadillo repeat-containing X-linked protein 3

Names: ARM protein lost in epithelial cancers on chromosome X 3; arm protein lost in epithelial cancers, X chromosome, 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_013222.2 RefSeqGene

Range

5002..9694

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_016607.4 → NP_057691.1 armadillo repeat-containing X-linked protein 3

See identical proteins and their annotated locations for NP_057691.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 encode the same protein.

Source sequence(s)

AC234775, BC005194, BG035798, BM905704, BX647802

Consensus CDS

CCDS14489.1

UniProtKB/Swiss-Prot

Q53HC6, Q7LCF5, Q9NPE4, Q9UH62

UniProtKB/TrEMBL

A8K5B0

Related

ENSP00000340672.4, ENST00000341189.8

Conserved Domains (2) summary

sd00043
Location:156 → 190

ARM; armadillo repeat [structural motif]

pfam04826
Location:112 → 363

Arm_2; Armadillo-like
NM_177947.3 → NP_808816.1 armadillo repeat-containing X-linked protein 3

See identical proteins and their annotated locations for NP_808816.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 encode the same protein.

Source sequence(s)

AC234775, BC005194, BG035798, BX647802

Consensus CDS

CCDS14489.1

UniProtKB/Swiss-Prot

Q53HC6, Q7LCF5, Q9NPE4, Q9UH62

UniProtKB/TrEMBL

A8K5B0

Related

ENSP00000454483.1, ENST00000471229.7

Conserved Domains (2) summary

sd00043
Location:156 → 190

ARM; armadillo repeat [structural motif]

pfam04826
Location:112 → 363

Arm_2; Armadillo-like
NM_177948.3 → NP_808817.1 armadillo repeat-containing X-linked protein 3

See identical proteins and their annotated locations for NP_808817.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1, and represents the shortest transcript. Variants 1, 2, and 3 encode the same protein.

Source sequence(s)

AC234775, BC005194, BM905704, BX647802, CA397688

Consensus CDS

CCDS14489.1

UniProtKB/Swiss-Prot

Q53HC6, Q7LCF5, Q9NPE4, Q9UH62

UniProtKB/TrEMBL

A8K5B0

Related

ENSP00000439032.1, ENST00000537169.1

Conserved Domains (2) summary

sd00043
Location:156 → 190

ARM; armadillo repeat [structural motif]

pfam04826
Location:112 → 363

Arm_2; Armadillo-like

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000023.11 Reference GRCh38.p14 Primary Assembly

Range

101623151..101627843

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005262141.4 → XP_005262198.1 armadillo repeat-containing X-linked protein 3 isoform X1

See identical proteins and their annotated locations for XP_005262198.1

UniProtKB/Swiss-Prot

Q53HC6, Q7LCF5, Q9NPE4, Q9UH62

UniProtKB/TrEMBL

A8K5B0

Conserved Domains (2) summary

sd00043
Location:156 → 190

ARM; armadillo repeat [structural motif]

pfam04826
Location:112 → 363

Arm_2; Armadillo-like

Alternate T2T-CHM13v2.0

Genomic

NC_060947.1 Alternate T2T-CHM13v2.0

Range

100067782..100072474

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054327180.1 → XP_054183155.1 armadillo repeat-containing X-linked protein 3 isoform X1

UniProtKB/Swiss-Prot

Q53HC6, Q7LCF5, Q9NPE4, Q9UH62

UniProtKB/TrEMBL

A8K5B0