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    SPE3 spermidine synthase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856182, updated on 2-Nov-2024

    Summary

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    Official Symbol
    SPE3
    Official Full Name
    spermidine synthase
    Primary source
    SGD:S000006273
    Locus tag
    YPR069C
    See related
    AllianceGenome:SGD:S000006273; FungiDB:YPR069C; VEuPathDB:YPR069C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables spermidine synthase activity. Involved in pantothenate biosynthetic process and spermidine biosynthetic process. Located in cytoplasm and nucleus. Orthologous to human SRM (spermidine synthase). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See SPE3 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (684556..685437, complement)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Isa2p Neighboring gene histone deacetylase Neighboring gene Med1p Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Formation of cadaverine derivatives in Saccharomyces cerevisiae. Walters DR, et al. FEMS Microbiol Lett, 1996 Dec 1. PMID 8961564
    2. Spermidine biosynthesis in Saccharomyces cerevisae: polyamine requirement of a null mutant of the SPE3 gene (spermidine synthase). Hamasaki-Katagiri N, et al. Gene, 1997 Mar 10. PMID 9073064
    3. Over-expression of the apple spermidine synthase gene in pear confers multiple abiotic stress tolerance by altering polyamine titers. Wen XP, et al. Transgenic Res, 2008 Apr. PMID 17549601
    4. The biochemistry, genetics, and regulation of polyamine biosynthesis in Saccharomyces cerevisiae. Tabor CW, et al. Fed Proc, 1982 Dec. PMID 6754461
    5. Spermidine but not spermine is essential for hypusine biosynthesis and growth in Saccharomyces cerevisiae: spermine is converted to spermidine in vivo by the FMS1-amine oxidase. Chattopadhyay MK, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14617780, Free PMC Article

    See all (66) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables spermidine synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables spermidine synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables spermidine synthase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in pantothenate biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in polyamine metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spermidine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spermidine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spermidine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    spermidine synthase
    NP_015394.1
    • Spermidine synthase; involved in biosynthesis of spermidine and also in biosynthesis of pantothenic acid; spermidine is required for growth of wild-type cells

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      684556..685437 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184166.1 → NP_015394.1  TPA: spermidine synthase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015394.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W473, Q12074
      UniProtKB/TrEMBL
      A6ZWV6, B3LLC2, B5VTL6, C7GY53, C8ZJ94, G2WPP1, N1NXL5
      Conserved Domains (1) summary
      TIGR00417
      Location:14 → 287
      speE; spermidine synthase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12074.1

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