SAM37 SAM complex subunit SAM37 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: SAM37
Official Full Name: SAM complex subunit SAM37
Primary source: SGD:S000004664
Locus tag: YMR060C
See related: AllianceGenome:SGD:S000004664; FungiDB:YMR060C; VEuPathDB:YMR060C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: MAS37; PET3027; TOM37
Summary: Involved in mitochondrial outer membrane translocase complex assembly; phospholipid transport; and protein insertion into mitochondrial outer membrane. Located in mitochondrial outer membrane. Part of SAM complex. Orthologous to human MTX1 (metaxin 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See SAM37 in Genome Data Viewer

Location:: chromosome: XIII

Exon count:: 1

Sequence:: Chromosome: XIII; NC_001145.3 (391532..392515, complement)

Chromosome XIII - NC_001145.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Positively charged amino acids at the N terminus of select mitochondrial proteins mediate early recognition by import proteins alphabeta'-NAC and Sam37.
Title: Positively charged amino acids at the N terminus of select mitochondrial proteins mediate early recognition by import proteins αβ'-NAC and Sam37.
Structural insight into the SAM-mediated assembly of the mitochondrial TOM core complex.
Title: Structural insight into the SAM-mediated assembly of the mitochondrial TOM core complex.
budding yeast mitochondrial outer membrane proteins that are subunits of the translocase of the outer mitochondrial membrane (Tom70 and Tom 22) and sorting and assembly machinery (Sam37) are required for efficient pretransfer RNA splicing.
Title: From powerhouse to processing plant: conserved roles of mitochondrial outer membrane proteins in tRNA splicing.
We propose that ab'-NAC and Sam37 are members of the system that recognizes mitochondrial proteins at early stages of their synthesis, escorting them to the import machinery of mitochondria.
Title: αβ'-NAC cooperates with Sam37 to mediate early stages of mitochondrial protein import.
Sam37 interacts with the receptor domain of Tom22 on the cytosolic side of the mitochondrial outer membrane and links TOM and SAM complexes.
Title: Sam37 is crucial for formation of the mitochondrial TOM-SAM supercomplex, thereby promoting β-barrel biogenesis.
Daya suggest that the assembly of newly imported Tom40 is directly initiated at the SAM complex (SAM37) by its association with Tom5.
Title: Assembly of the mitochondrial protein import channel: role of Tom5 in two-stage interaction of Tom40 with the SAM complex.
Overexpression of SAM37 suppresses the growth phenotype of tom6Delta, and cells lacking both genes are not viable.
Title: Genetic and functional interactions between the mitochondrial outer membrane proteins Tom6 and Sam37.
Assembly of newly synthesized Tob55 into preexisting TOB complexes depended on Tob38 but did not require Mas37
Title: Assembly of the TOB complex of mitochondria.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in mitochondrial outer membrane translocase complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrion organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipid transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein insertion into mitochondrial outer membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of SAM complex	IBA Inferred from Biological aspect of Ancestor more info
part_of SAM complex	IDA Inferred from Direct Assay more info	PubMed
part_of SAM complex	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial outer membrane	HDA more info	PubMed
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: SAM complex subunit SAM37

NP_013776.1

Component of the Sorting and Assembly Machinery (SAM) complex; the SAM (or TOB) complex is located in the mitochondrial outer membrane; binds precursors of beta-barrel proteins and facilitates their outer membrane insertion; contributes to SAM complex stability

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001145.3 Reference assembly

Range

391532..392515 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001182558.1 → NP_013776.1 TPA: SAM complex subunit SAM37 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_013776.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VZN4, P50110

UniProtKB/TrEMBL

A6ZMB9

Conserved Domains (2) summary

pfam11801
Location:183 → 326

Tom37_C; Tom37 C-terminal domain

pfam10568
Location:22 → 162

Tom37; Outer mitochondrial membrane transport complex protein