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    MED8 Med8p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852492, updated on 2-Nov-2024

    Summary

    Official Symbol
    MED8
    Official Full Name
    Med8p
    Primary source
    SGD:S000000397
    Locus tag
    YBR193C
    See related
    AllianceGenome:SGD:S000000397; FungiDB:YBR193C; VEuPathDB:YBR193C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; TBP-class protein binding activity; and transcription corepressor activity. Involved in negative regulation of transcription by RNA polymerase II and positive regulation of transcription by RNA polymerase II. Part of core mediator complex. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

    See MED8 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (609082..609753, complement)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene ribosomal 60S subunit protein L21A Neighboring gene Rim2p Neighboring gene Aim4p Neighboring gene Msi1p

    Bibliography

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables TBP-class protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein-macromolecule adaptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables transcription coregulator activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transcription corepressor activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of core mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of core mediator complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of mediator complex IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    Med8p
    NP_009752.3
    • Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      609082..609753 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178541.3NP_009752.3  TPA: Med8p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009752.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQI7, P38304
      UniProtKB/TrEMBL
      A6ZLD3, C7GKF2, D3UET7, G2W9J4, N1P9K0
      Conserved Domains (1) summary
      pfam10232
      Location:32127
      Med8; Mediator of RNA polymerase II transcription complex subunit 8