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    Slc39a3 solute carrier family 39 (zinc transporter), member 3 [ Mus musculus (house mouse) ]

    Gene ID: 106947, updated on 9-Dec-2024

    Summary

    Official Symbol
    Slc39a3provided by MGI
    Official Full Name
    solute carrier family 39 (zinc transporter), member 3provided by MGI
    Primary source
    MGI:MGI:2147269
    See related
    Ensembl:ENSMUSG00000046822 AllianceGenome:MGI:2147269
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Zip3; ZIP-3
    Summary
    Enables zinc ion transmembrane transporter activity. Involved in zinc ion transmembrane transport. Acts upstream of or within several processes, including T cell homeostasis; chordate embryonic development; and zinc ion transport. Located in apical plasma membrane and hippocampal mossy fiber to CA3 synapse. Is expressed in several structures, including genitourinary system; gut; nervous system; sensory organ; and yolk sac. Orthologous to human SLC39A3 (solute carrier family 39 member 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 57.2), ovary adult (RPKM 21.7) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Slc39a3 in Genome Data Viewer
    Location:
    10 C1; 10 39.72 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (80864374..80873169, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (81028540..81037338, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene ATP synthase subunit f, mitochondrial-like Neighboring gene STARR-seq mESC enhancer starr_27308 Neighboring gene guanine nucleotide binding protein (G protein), gamma 7 Neighboring gene STARR-seq mESC enhancer starr_27310 Neighboring gene STARR-positive B cell enhancer ABC_E2951 Neighboring gene STARR-positive B cell enhancer ABC_E1807 Neighboring gene STARR-positive B cell enhancer ABC_E10629 Neighboring gene DIRAS family, GTP-binding RAS-like 1 Neighboring gene predicted gene 16099 Neighboring gene STARR-positive B cell enhancer ABC_E2952 Neighboring gene small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha Neighboring gene STARR-positive B cell enhancer ABC_E1808 Neighboring gene STARR-positive B cell enhancer ABC_E462 Neighboring gene thimet oligopeptidase 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2)  1 citation

    General gene information

    Markers

    Clone Names

    • MGC7461, MGC109671

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables zinc ion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables zinc ion transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables zinc ion transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in hippocampal mossy fiber to CA3 synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 

    General protein information

    Preferred Names
    zinc transporter ZIP3
    Names
    solute carrier family 39 member 3
    zrt- and Irt-like protein 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001358898.2NP_001345827.2  zinc transporter ZIP3

      Status: VALIDATED

      Source sequence(s)
      AC152500
      Consensus CDS
      CCDS24041.1
      UniProtKB/Swiss-Prot
      Q99K24
      Related
      ENSMUSP00000113147.5, ENSMUST00000117276.11
      Conserved Domains (1) summary
      pfam02535
      Location:5312
      Zip; ZIP Zinc transporter
    2. NM_134135.3NP_598896.3  zinc transporter ZIP3

      Status: VALIDATED

      Source sequence(s)
      AC152500
      Consensus CDS
      CCDS24041.1
      UniProtKB/Swiss-Prot
      Q99K24
      Related
      ENSMUSP00000057094.7, ENSMUST00000059551.7
      Conserved Domains (1) summary
      pfam02535
      Location:5312
      Zip; ZIP Zinc transporter

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      80864374..80873169 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011243260.4XP_011241562.1  zinc transporter ZIP3 isoform X1

      See identical proteins and their annotated locations for XP_011241562.1

      UniProtKB/TrEMBL
      A0A452J893
      Related
      ENSMUSP00000128256.2, ENSMUST00000168076.2
      Conserved Domains (1) summary
      pfam02535
      Location:36343
      Zip; ZIP Zinc transporter
    2. XM_006513027.4XP_006513090.1  zinc transporter ZIP3 isoform X1

      See identical proteins and their annotated locations for XP_006513090.1

      UniProtKB/TrEMBL
      A0A452J893
      Conserved Domains (1) summary
      pfam02535
      Location:36343
      Zip; ZIP Zinc transporter
    3. XM_030244802.2XP_030100662.1  zinc transporter ZIP3 isoform X1

      UniProtKB/TrEMBL
      A0A452J893
      Conserved Domains (1) summary
      pfam02535
      Location:36343
      Zip; ZIP Zinc transporter