Gstt1 glutathione S-transferase, theta 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gstt1provided by MGI
Official Full Name: glutathione S-transferase, theta 1provided by MGI
Primary source: MGI:MGI:107379
See related: Ensembl:ENSMUSG00000001663 AllianceGenome:MGI:107379
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gstt1-1
Summary: Enables glutathione transferase activity. Involved in glutathione metabolic process. Located in cytosol. Is expressed in several structures, including alimentary system; eye; genitourinary system; nervous system; and respiratory system. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); cancer (multiple); cardiovascular system disease (multiple); eye disease (multiple); and lung disease (multiple). Orthologous to human GSTT1 (glutathione S-transferase theta 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in liver adult (RPKM 231.7), kidney adult (RPKM 100.7) and 15 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 C1; 10 38.58 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (75619647..75634418, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (75783813..75798584, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Gstm1/Gstt1 is essential for reducing cisplatin ototoxicity in CBA/CaJ mice.
Title: Gstm1/Gstt1 is essential for reducing cisplatin ototoxicity in CBA/CaJ mice.
Glutathione S-transferase theta 1 protects against colitis through goblet cell differentiation via interleukin-22.
Title: Glutathione S-transferase theta 1 protects against colitis through goblet cell differentiation via interleukin-22.
minor structural changes in the C-terminal helix of mouse GST T1-1 induce major changes in the substrate-activity profile of the enzyme to favor novel chemical reactions and to suppress other reactions catalyzed by the parental enzyme
Title: Minor modifications of the C-terminal helix reschedule the favored chemical reactions catalyzed by theta class glutathione transferase T1-1.
Gstt1-null mice would be useful as an animal model of humans with the GSTT1-null genotype.
Title: Generation and functional characterization of mice with a disrupted glutathione S-transferase, theta 1 gene.
The carcinogenic effects of DCM in the mouse are caused by the interaction with DNA of a glutathione (GSH) conjugate that is produced by the class theta glutathione S-transferase T1-1 (GST T1-1).
Title: Direct comparison of the nature of mouse and human GST T1-1 and the implications on dichloromethane carcinogenicity.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI255817 (e-PCR)
- UniSTS:165701

Gstt1 (e-PCR), detects polymorphism
- UniSTS:506960

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables alkylhalidase activity	IEA Inferred from Electronic Annotation more info
enables alkylhalidase activity	ISO Inferred from Sequence Orthology more info
enables glutathione peroxidase activity	IEA Inferred from Electronic Annotation more info
enables glutathione peroxidase activity	ISO Inferred from Sequence Orthology more info
enables glutathione transferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutathione transferase activity	IDA Inferred from Direct Assay more info	PubMed
enables glutathione transferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA modification	IEA Inferred from Electronic Annotation more info
involved_in DNA modification	ISO Inferred from Sequence Orthology more info
involved_in cellular oxidant detoxification	IEA Inferred from Electronic Annotation more info
involved_in dichloromethane metabolic process	IEA Inferred from Electronic Annotation more info
involved_in dichloromethane metabolic process	ISO Inferred from Sequence Orthology more info
involved_in glutathione metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within glutathione metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in glutathione metabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within glutathione metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glutathione metabolic process	ISO Inferred from Sequence Orthology more info
involved_in response to salicylic acid	IEA Inferred from Electronic Annotation more info
involved_in response to selenium ion	IEA Inferred from Electronic Annotation more info
involved_in response to vitamin E	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: glutathione S-transferase theta-1

Names: GST class-theta-1

NP_001345707.1

EC 2.5.1.18

NP_032211.3

EC 2.5.1.18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001358778.1 → NP_001345707.1 glutathione S-transferase theta-1 isoform 2

Status: VALIDATED

Source sequence(s)

AA791018, AC142499, BE655658, BP772123

UniProtKB/TrEMBL

D3Z3X5

Related

ENSMUSP00000113839.2, ENSMUST00000120177.8

Conserved Domains (2) summary

cd03183
Location:41 → 167

GST_C_Theta; C-terminal, alpha helical domain of Class Theta Glutathione S-transferases

cl00388
Location:1 → 28

Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
NM_008185.3 → NP_032211.3 glutathione S-transferase theta-1 isoform 1

See identical proteins and their annotated locations for NP_032211.3

Status: VALIDATED

Source sequence(s)

AI255817, AK002338, BY015234, W54467

Consensus CDS

CCDS23932.1

UniProtKB/Swiss-Prot

Q64471, Q91X50

UniProtKB/TrEMBL

Q9DCY6

Related

ENSMUSP00000001713.4, ENSMUST00000001713.10

Conserved Domains (3) summary

cd03183
Location:91 → 217

GST_C_Theta; C-terminal, alpha helical domain of Class Theta Glutathione S-transferases

COG0625
Location:3 → 212

GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]

cd03050
Location:3 → 78

GST_N_Theta; GST_N family, Class Theta subfamily; composed of eukaryotic class Theta GSTs and bacterial dichloromethane (DCM) dehalogenase. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with ...