U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Papss2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 [ Mus musculus (house mouse) ]

    Gene ID: 23972, updated on 9-Dec-2024

    Summary

    Official Symbol
    Papss2provided by MGI
    Official Full Name
    3'-phosphoadenosine 5'-phosphosulfate synthase 2provided by MGI
    Primary source
    MGI:MGI:1330223
    See related
    Ensembl:ENSMUSG00000024899 AllianceGenome:MGI:1330223
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    bm; Sk2; AtpsU2; Atpsk2; 1810018P12Rik
    Summary
    Enables adenylylsulfate kinase activity and sulfate adenylyltransferase (ATP) activity. Involved in 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process. Acts upstream of or within blood coagulation; bone development; and sulfate assimilation. Predicted to be active in cytosol. Is expressed in several structures, including genitourinary system; heart; limb; sensory organ; and skeleton. Used to study spondyloepimetaphyseal dysplasia, Pakistani type. Human ortholog(s) of this gene implicated in spondyloepimetaphyseal dysplasia, Pakistani type. Orthologous to human PAPSS2 (3'-phosphoadenosine 5'-phosphosulfate synthase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in kidney adult (RPKM 50.1), small intestine adult (RPKM 40.8) and 12 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Papss2 in Genome Data Viewer
    Location:
    19 C1; 19 27.46 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (32573072..32644587)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (32595669..32667187)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene multiple inositol polyphosphate histidine phosphatase 1 Neighboring gene STARR-seq mESC enhancer starr_45949 Neighboring gene predicted gene, 36419 Neighboring gene STARR-seq mESC enhancer starr_45950 Neighboring gene predicted gene, 36492 Neighboring gene ATPase family, AAA domain containing 1 Neighboring gene STARR-positive B cell enhancer mm9_chr19:32786522-32786822 Neighboring gene STARR-positive B cell enhancer mm9_chr19:32787156-32787457 Neighboring gene STARR-seq mESC enhancer starr_45951 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:32828923-32829124 Neighboring gene STARR-positive B cell enhancer ABC_E7646 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:32830866-32830975 Neighboring gene killin, p53-regulated DNA replication inhibitor pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables adenylylsulfate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables adenylylsulfate kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables adenylylsulfate kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables nucleotidyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables sulfate adenylyltransferase (ATP) activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables sulfate adenylyltransferase (ATP) activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables sulfate adenylyltransferase (ATP) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2
    Names
    PAPS synthase 2
    brachymorphic
    sulfurylase kinase 2
    NP_001188399.1
    NP_001347332.1
    NP_035994.2
    XP_006527127.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001201470.1NP_001188399.1  bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC162887, AK137675, BY224664
      Consensus CDS
      CCDS89376.1
      UniProtKB/TrEMBL
      A0A494B923, Q9QYS0
      Related
      ENSMUSP00000157455.2, ENSMUST00000235594.2
      Conserved Domains (3) summary
      cd00517
      Location:243606
      ATPS; ATP-sulfurylase
      cd02027
      Location:43193
      APSK; Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form important for the assimilation of ...
      TIGR00339
      Location:234605
      sopT; ATP sulphurylase
    2. NM_001360403.1NP_001347332.1  bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC162887
      Consensus CDS
      CCDS89377.1
      UniProtKB/TrEMBL
      A0A494BB18, Q9QYS0
      Related
      ENSMUSP00000158330.2, ENSMUST00000236290.2
      Conserved Domains (2) summary
      cd00517
      Location:245608
      ATPS; ATP-sulfurylase
      cd02027
      Location:45195
      APSK; Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form important for the assimilation of ...
    3. NM_011864.3NP_035994.2  bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 isoform 1

      See identical proteins and their annotated locations for NP_035994.2

      Status: VALIDATED

      Source sequence(s)
      AC162887
      Consensus CDS
      CCDS37960.1
      UniProtKB/Swiss-Prot
      O88428, Q5BKP4, Q9Z274
      UniProtKB/TrEMBL
      Q9QYS0
      Related
      ENSMUSP00000025833.7, ENSMUST00000025833.7
      Conserved Domains (3) summary
      cd00517
      Location:245613
      ATPS; ATP-sulfurylase
      cd02027
      Location:45195
      APSK; Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form important for the assimilation of ...
      TIGR00339
      Location:236612
      sopT; ATP sulphurylase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      32573072..32644587
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006527064.5XP_006527127.1  bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 isoform X1

      UniProtKB/TrEMBL
      Q9QYS0
      Conserved Domains (2) summary
      cd00517
      Location:243611
      ATPS; ATP-sulfurylase
      cd02027
      Location:43193
      APSK; Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form important for the assimilation of ...