U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Mthfd2l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like [ Mus musculus (house mouse) ]

    Gene ID: 665563, updated on 27-Nov-2024

    Summary

    Official Symbol
    Mthfd2lprovided by MGI
    Official Full Name
    methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-likeprovided by MGI
    Primary source
    MGI:MGI:1915871
    See related
    Ensembl:ENSMUSG00000029376 AllianceGenome:MGI:1915871
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1110019K23Rik; C630010D07Rik
    Summary
    Predicted to enable methenyltetrahydrofolate cyclohydrolase activity; methylenetetrahydrofolate dehydrogenase (NAD+) activity; and methylenetetrahydrofolate dehydrogenase (NADP+) activity. Predicted to be involved in 10-formyltetrahydrofolate metabolic process and tetrahydrofolate interconversion. Predicted to be located in mitochondrial inner membrane and mitochondrial matrix. Predicted to be active in mitochondrion. Is expressed in several structures, including central nervous system; future brain; gonad; gut; and retina nuclear layer. Orthologous to human MTHFD2L (methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E14 (RPKM 10.4), whole brain E14.5 (RPKM 10.0) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Mthfd2l in Genome Data Viewer
    Location:
    5 E1; 5 44.78 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (91078704..91169227)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (90930873..91021368)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6344 Neighboring gene C-X-C motif chemokine ligand 1 Neighboring gene C-X-C motif chemokine ligand 2 Neighboring gene STARR-seq mESC enhancer starr_13609 Neighboring gene STARR-seq mESC enhancer starr_13610 Neighboring gene predicted gene, 52819 Neighboring gene epithelial mitogen Neighboring gene predicted gene, 19610 Neighboring gene epiregulin

    Genomic regions, transcripts, and products

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in 10-formyltetrahydrofolate metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in 10-formyltetrahydrofolate metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in L-histidine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in methionine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in purine nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in tetrahydrofolate interconversion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in tetrahydrofolate interconversion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in tetrahydrofolate interconversion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in tetrahydrofolate interconversion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial
    Names
    MTHFD2-like
    NADP-dependent methylenetetrahydrofolate dehydrogenase 2-like protein
    probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2
    NP_081064.1
    XP_006535239.1
    XP_006535240.1
    XP_006535241.1
    XP_030110616.1
    XP_030110617.1
    XP_030110618.1
    XP_030110619.1
    XP_030110620.1
    XP_036021300.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026788.1NP_081064.1  bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial

      See identical proteins and their annotated locations for NP_081064.1

      Status: VALIDATED

      Source sequence(s)
      AC109311, AC157938, AK003824, BU610697, BY014284, CO042485
      Consensus CDS
      CCDS39145.1
      UniProtKB/Swiss-Prot
      D3YZG8
      Related
      ENSMUSP00000071578.5, ENSMUST00000071652.6
      Conserved Domains (3) summary
      cd01080
      Location:155334
      NAD_bind_m-THF_DH_Cyclohyd; NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase
      COG0190
      Location:44335
      FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]
      pfam00763
      Location:44160
      THF_DHG_CYH; Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      91078704..91169227
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030254760.2XP_030110620.1  bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial isoform X9

      Conserved Domains (1) summary
      COG0190
      Location:2199
      FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]
    2. XM_030254759.2XP_030110619.1  bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial isoform X8

      Conserved Domains (1) summary
      COG0190
      Location:72234
      FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]
    3. XM_006535178.5XP_006535241.1  bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial isoform X5

      Conserved Domains (1) summary
      COG0190
      Location:72276
      FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]
    4. XM_030254758.2XP_030110618.1  bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial isoform X7

      Conserved Domains (1) summary
      COG0190
      Location:2244
      FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]
    5. XM_036165407.1XP_036021300.1  bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial isoform X6

      Conserved Domains (1) summary
      COG0190
      Location:44248
      FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]
    6. XM_030254757.2XP_030110617.1  bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial isoform X4

      Conserved Domains (1) summary
      COG0190
      Location:2286
      FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]
    7. XM_006535177.5XP_006535240.1  bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial isoform X2

      Conserved Domains (1) summary
      COG0190
      Location:72321
      FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]
    8. XM_006535176.5XP_006535239.1  bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial isoform X1

      Conserved Domains (1) summary
      COG0190
      Location:72363
      FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]
    9. XM_030254756.2XP_030110616.1  bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial isoform X3

      Conserved Domains (1) summary
      COG0190
      Location:44293
      FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]

    RNA

    1. XR_001784735.3 RNA Sequence

    2. XR_003955692.2 RNA Sequence