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    ENT2 epsin [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850903, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ENT2
    Official Full Name
    epsin
    Primary source
    SGD:S000004196
    Locus tag
    YLR206W
    See related
    AllianceGenome:SGD:S000004196; FungiDB:YLR206W; VEuPathDB:YLR206W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables K48-linked polyubiquitin modification-dependent protein binding activity and K63-linked polyubiquitin modification-dependent protein binding activity. Involved in actin cortical patch assembly; actin filament organization; and endocytosis. Located in mating projection tip. Orthologous to several human genes including EPN1 (epsin 1) and EPN3 (epsin 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ENT2 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (554578..556419)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene mitochondrial 37S ribosomal protein QRI5 Neighboring gene Hmx1p Neighboring gene ubiquitin ligase complex subunit HRD3 Neighboring gene GTPase-activating protein SEC13

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Crystallographic analysis of the ENTH domain from yeast epsin Ent2 that induces a cell division phenotype. Costakes GT, et al. Protein Sci, 2013 Jun. PMID 23553749, Free PMC Article
    2. The Information Content of Glutamine-Rich Sequences Define Protein Functional Characteristics. Sen A, et al. Proc IEEE Inst Electr Electron Eng, 2017 Feb. PMID 32963411, Free PMC Article
    3. Identification of a novel domain shared by putative components of the endocytic and cytoskeletal machinery. Kay BK, et al. Protein Sci, 1999 Feb. PMID 10048338, Free PMC Article
    4. Clathrin functions in the absence of the terminal domain binding site for adaptor-associated clathrin-box motifs. Collette JR, et al. Mol Biol Cell, 2009 Jul. PMID 19458198, Free PMC Article
    5. In vivo role for actin-regulating kinases in endocytosis and yeast epsin phosphorylation. Watson HA, et al. Mol Biol Cell, 2001 Nov. PMID 11694597, Free PMC Article

    See all (67) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cooperative regulation of endocytic vesicle transport by yeast Eps15-like protein Pan1p and epsins.
      Title: Cooperative regulation of endocytic vesicle transport by yeast Eps15-like protein Pan1p and epsins.
    2. Structural data of wild type and mutant Epsin N-terminal homology (ENTH) domain from ENT2 and in vivo phenotypic analysis of ENTH2 overexpressing cells indicate that the biochemical nature of three loop 7 residues is crucial for its role in cytokinesis.
      Title: Crystallographic analysis of the ENTH domain from yeast epsin Ent2 that induces a cell division phenotype.
    3. The yeast endocytic protein Epsin 2 functions in a cell-division signaling pathway.
      Title: The yeast endocytic protein Epsin 2 functions in a cell-division signaling pathway.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables K48-linked polyubiquitin modification-dependent protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables K63-linked polyubiquitin modification-dependent protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables clathrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables clathrin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin cortical patch assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin filament organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of clathrin vesicle coat IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mating projection tip HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    epsin
    NP_013307.1
    • Epsin-like protein required for endocytosis and actin patch assembly; K48-, K63-specific Ub chain binding protein that functions as an endocytic adaptor; contains clathrin-binding motif at C-terminus; functionally redundant with Ent1p; ENT2 has a paralog, ENT1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      554578..556419
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182093.1 → NP_013307.1  TPA: epsin [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013307.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VYK7, Q05785
      UniProtKB/TrEMBL
      B3RH95, N1NZE3
      Conserved Domains (1) summary
      cd16991
      Location:15 → 145
      ENTH_Ent1_Ent2; Epsin N-Terminal Homology (ENTH) domain of Yeast Ent1, Ent2, and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q05785.1

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