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    Ndufs7 NADH:ubiquinone oxidoreductase core subunit S7 [ Mus musculus (house mouse) ]

    Gene ID: 75406, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ndufs7provided by MGI
    Official Full Name
    NADH:ubiquinone oxidoreductase core subunit S7provided by MGI
    Primary source
    MGI:MGI:1922656
    See related
    Ensembl:ENSMUSG00000020153 AllianceGenome:MGI:1922656
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CI-20kD; 1010001M04Rik
    Summary
    Predicted to enable NADH dehydrogenase (ubiquinone) activity and protease binding activity. Predicted to contribute to NADH dehydrogenase activity. Predicted to be involved in electron transport coupled proton transport; mitochondrial electron transport, NADH to ubiquinone; and mitochondrial respiratory chain complex I assembly. Located in mitochondrial inner membrane. Is expressed in several structures, including alimentary system; integumental system; respiratory system; retina; and urinary system. Human ortholog(s) of this gene implicated in developmental disorder of mental health and nuclear type mitochondrial complex I deficiency 3. Orthologous to human NDUFS7 (NADH:ubiquinone oxidoreductase core subunit S7). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in heart adult (RPKM 322.2), duodenum adult (RPKM 296.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ndufs7 in Genome Data Viewer
    Location:
    10 C1; 10 39.72 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (80084939..80092628)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (80249105..80256794)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3898 Neighboring gene PWWP domain containing 3A, DNA repair factor Neighboring gene nuclear encoded tRNA pheylalanine 3 (anticodon GAA) Neighboring gene nuclear encoded tRNA asparagine 7 (anticodon GTT) Neighboring gene STARR-positive B cell enhancer ABC_E5153 Neighboring gene STARR-positive B cell enhancer ABC_E10627 Neighboring gene guanidinoacetate methyltransferase Neighboring gene DAZ associated protein 1 Neighboring gene microRNA 6911

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Assignment of the PSST subunit gene of human mitochondrial complex I to chromosome 19p13. Hyslop SJ, et al. Genomics, 1996 Nov 1. PMID 8938450
    2. Region-specific expression of mitochondrial complex I genes during murine brain development. Wirtz S, et al. PLoS One, 2011 Apr 27. PMID 21556144, Free PMC Article
    3. Spatiotemporal gene expression patterns reveal molecular relatedness between retinal laminae. Jiang D, et al. J Comp Neurol, 2020 Apr 1. PMID 31609468, Free PMC Article
    4. SCAF1 drives the compositional diversity of mammalian respirasomes. Vercellino I, et al. Nat Struct Mol Biol, 2024 Jul. PMID 38575788
    5. Searching QTL by gene expression: analysis of diabesity. Brown AC, et al. BMC Genet, 2005 Mar 10. PMID 15760467, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 4 iron, 4 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NADH dehydrogenase (ubiquinone) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables NADH dehydrogenase (ubiquinone) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables NADH dehydrogenase (ubiquinone) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    contributes_to NADH dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to NADH dehydrogenase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protease binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables quinone binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in aerobic respiration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in aerobic respiration NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in electron transport coupled proton transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial electron transport, NADH to ubiquinone ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial electron transport, NADH to ubiquinone ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mitochondrial respiratory chain complex I assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial respiratory chain complex I assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial respiratory chain complex I assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in proton motive force-driven mitochondrial ATP synthesis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane HDA PubMed 
    is_active_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of respiratory chain complex I IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of respiratory chain complex I IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of respiratory chain complex I ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of respiratory chain complex I ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in synaptic membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial
    Names
    NADH dehydrogenase (ubiquinone) Fe-S protein 7
    NADH-ubiquinone oxidoreductase 20 kDa subunit
    complex I-20kD
    NP_001351623.1
    NP_083548.1
    XP_006514333.1
    XP_030101204.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001364694.1 → NP_001351623.1  NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC140229
      Conserved Domains (1) summary
      PRK06411
      Location:74 → 192
      PRK06411; NADH dehydrogenase subunit B; Validated

    2. NM_029272.4 → NP_083548.1  NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial isoform 1 precursor

      See identical proteins and their annotated locations for NP_083548.1

      Status: VALIDATED

      Source sequence(s)
      AC140229
      Consensus CDS
      CCDS24015.1
      UniProtKB/Swiss-Prot
      Q9DC70
      Related
      ENSMUSP00000020361.7, ENSMUST00000020361.7
      Conserved Domains (1) summary
      PRK06411
      Location:74 → 224
      PRK06411; NADH-quinone oxidoreductase subunit NuoB

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      80084939..80092628
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006514270.2 → XP_006514333.1  NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial isoform X2

      Conserved Domains (1) summary
      PRK06411
      Location:46 → 196
      PRK06411; NADH-quinone oxidoreductase subunit NuoB

    2. XM_030245344.2 → XP_030101204.1  NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial isoform X1

      UniProtKB/Swiss-Prot
      Q9DC70
      Related
      ENSMUSP00000101003.2, ENSMUST00000105364.8
      Conserved Domains (1) summary
      PRK06411
      Location:74 → 224
      PRK06411; NADH-quinone oxidoreductase subunit NuoB
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DC70.1 GenPept UniProtKB/Swiss-Prot:Q9DC70

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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