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    RCR2 Rcr2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851566, updated on 27-Dec-2024

    Summary

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    Official Symbol
    RCR2
    Official Full Name
    Rcr2p
    Primary source
    SGD:S000002410
    Locus tag
    YDR003W
    See related
    AllianceGenome:SGD:S000002410; FungiDB:YDR003W; VEuPathDB:YDR003W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    SSH5
    Summary
    Enables protein-macromolecule adaptor activity. Involved in protein localization to vacuole and vesicle-mediated transport. Located in vesicle. Is active in fungal-type vacuole. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See RCR2 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (454122..454754)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene alpha,alpha-trehalase NTH1 Neighboring gene Ran GTPase-binding protein YRB1 Neighboring gene uncharacterized protein Neighboring gene putative DNA-dependent ATPase RAD57

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A novel endoplasmic reticulum membrane protein Rcr1 regulates chitin deposition in the cell wall of Saccharomyces cerevisiae. Imai K, et al. J Biol Chem, 2005 Mar 4. PMID 15590673
    2. Ssh4, Rcr2 and Rcr1 affect plasma membrane transporter activity in Saccharomyces cerevisiae. Kota J, et al. Genetics, 2007 Apr. PMID 17287526, Free PMC Article
    3. Dissecting the gene network of dietary restriction to identify evolutionarily conserved pathways and new functional genes. Wuttke D, et al. PLoS Genet, 2012. PMID 22912585, Free PMC Article
    4. Calcineurin-dependent regulation of endocytosis by a plasma membrane ubiquitin ligase adaptor, Rcr1. Zhu L, et al. J Cell Biol, 2020 Aug 3. PMID 32421152, Free PMC Article
    5. The Saccharomyces cerevisiae Ptc1 protein phosphatase attenuates G2-M cell cycle blockage caused by activation of the cell wall integrity pathway. Tatjer L, et al. Mol Microbiol, 2016 Aug. PMID 27169355

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables protein-macromolecule adaptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein localization to vacuole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle-mediated transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in fungal-type vacuole HDA PubMed 
    is_active_in fungal-type vacuole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in fungal-type vacuole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in fungal-type vacuole membrane HDA PubMed 
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Rcr2p
    NP_010286.3
    • Vacuolar ubiquitin ligase-substrate adaptor; delivered to vacuole using ubiquitin as a sorting signal; presumably functions within the endosomal-vacuolar trafficking pathway, affecting events that determine whether plasma membrane proteins are degraded or routed to the plasma membrane; RCR2 has a paralog, RCR1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      454122..454754
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180311.3 → NP_010286.3  TPA: Rcr2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010286.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VRZ0, Q03446
      UniProtKB/TrEMBL
      A6ZXW8, B3LGQ6, C7GXY8, C8Z4S2, G2WCF6, N1P4F5
      Conserved Domains (1) summary
      pfam12273
      Location:40 → 152
      RCR; Chitin synthesis regulation, resistance to Congo red
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03446.1

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