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    Snx19 sorting nexin 19 [ Mus musculus (house mouse) ]

    Gene ID: 102607, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Snx19provided by MGI
    Official Full Name
    sorting nexin 19provided by MGI
    Primary source
    MGI:MGI:1921581
    See related
    Ensembl:ENSMUSG00000031993 AllianceGenome:MGI:1921581
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA0254; 3526401K03Rik
    Summary
    Predicted to enable phosphatidylinositol binding activity. Acts upstream of or within several processes, including chondrocyte differentiation; dense core granule maturation; and insulin secretion. Predicted to be active in intracellular membrane-bounded organelle. Is expressed in limb; tibia; and vertebral cartilage condensation. Orthologous to human SNX19 (sorting nexin 19). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 7.0), subcutaneous fat pad adult (RPKM 5.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Snx19 in Genome Data Viewer
    Location:
    9 A4; 9 16.04 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (30338284..30378437)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (30426988..30467141)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 26435 Neighboring gene predicted gene, 30933 Neighboring gene STARR-seq mESC enhancer starr_23665 Neighboring gene STARR-seq mESC enhancer starr_23666 Neighboring gene ribosomal protein S2, pseudogene 12 Neighboring gene STARR-seq mESC enhancer starr_23667 Neighboring gene STARR-seq mESC enhancer starr_23669 Neighboring gene STARR-seq mESC enhancer starr_23670 Neighboring gene predicted gene, 31013

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Screening of chondrogenic factors with a real-time fluorescence-monitoring cell line ATDC5-C2ER: identification of sorting nexin 19 as a novel factor. Kan A, et al. Arthritis Rheum, 2009 Nov. PMID 19877062
    2. Structural basis for different phosphoinositide specificities of the PX domains of sorting nexins regulating G-protein signaling. Mas C, et al. J Biol Chem, 2014 Oct 10. PMID 25148684, Free PMC Article
    3. Sorting nexin 19 regulates the number of dense core vesicles in pancreatic β-cells. Harashima S, et al. J Diabetes Investig, 2012 Feb 20. PMID 24843546, Free PMC Article
    4. Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Feb 28. PMID 12693553
    5. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SNX19 and SNX14 PX domains reveal key differences in spatial control of RGS-PX proteins in cell signaling and trafficking.
      Title: Structural basis for different phosphoinositide specificities of the PX domains of sorting nexins regulating G-protein signaling.
    2. The ATDC5-C2ER cell line system can be used for efficient monitoring of chondrogenic differentiation by fluorescence analysis. A novel chondrogenic factor (SNX19) is identified for elucidating the molecular network of chondrogenic differentiation.
      Title: Screening of chondrogenic factors with a real-time fluorescence-monitoring cell line ATDC5-C2ER: identification of sorting nexin 19 as a novel factor.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables phosphatidylinositol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within chondrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within dense core granule maturation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within establishment of localization in cell IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in exocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within insulin secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    sorting nexin-19

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028874.2 → NP_083150.1  sorting nexin-19

      See identical proteins and their annotated locations for NP_083150.1

      Status: PROVISIONAL

      Source sequence(s)
      AC160339, CU024910
      Consensus CDS
      CCDS22944.1
      UniProtKB/Swiss-Prot
      Q3TQ83, Q6P4T1, Q80U53
      Related
      ENSMUSP00000131895.2, ENSMUST00000164099.3
      Conserved Domains (3) summary
      cd06893
      Location:537 → 664
      PX_SNX19; The phosphoinositide binding Phox Homology domain of Sorting Nexin 19
      smart00313
      Location:95 → 273
      PXA; Domain associated with PX domains
      pfam08628
      Location:850 → 950
      Nexin_C; Sorting nexin C terminal

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      30338284..30378437
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017313068.2 → XP_017168557.1  sorting nexin-19 isoform X4

      Conserved Domains (2) summary
      cd06893
      Location:537 → 664
      PX_SNX19; The phosphoinositide binding Phox Homology domain of Sorting Nexin 19
      smart00313
      Location:95 → 273
      PXA; Domain associated with PX domains

    2. XM_030243948.2 → XP_030099808.1  sorting nexin-19 isoform X1

      Conserved Domains (3) summary
      cd06893
      Location:537 → 664
      PX_SNX19; The phosphoinositide binding Phox Homology domain of Sorting Nexin 19
      smart00313
      Location:95 → 273
      PXA; Domain associated with PX domains
      pfam08628
      Location:850 → 951
      Nexin_C; Sorting nexin C terminal

    3. XM_006509906.5 → XP_006509969.1  sorting nexin-19 isoform X5

      Conserved Domains (2) summary
      cd06893
      Location:537 → 664
      PX_SNX19; The phosphoinositide binding Phox Homology domain of Sorting Nexin 19
      smart00313
      Location:95 → 273
      PXA; Domain associated with PX domains

    4. XM_030243950.1 → XP_030099810.1  sorting nexin-19 isoform X3

      Conserved Domains (2) summary
      cd06893
      Location:537 → 664
      PX_SNX19; The phosphoinositide binding Phox Homology domain of Sorting Nexin 19
      smart00313
      Location:95 → 273
      PXA; Domain associated with PX domains

    5. XM_030243951.1 → XP_030099811.1  sorting nexin-19 isoform X6

      Conserved Domains (2) summary
      cd06893
      Location:537 → 664
      PX_SNX19; The phosphoinositide binding Phox Homology domain of Sorting Nexin 19
      smart00313
      Location:95 → 273
      PXA; Domain associated with PX domains

    6. XM_030243949.2 → XP_030099809.1  sorting nexin-19 isoform X2

      Conserved Domains (2) summary
      cd06893
      Location:537 → 664
      PX_SNX19; The phosphoinositide binding Phox Homology domain of Sorting Nexin 19
      smart00313
      Location:95 → 273
      PXA; Domain associated with PX domains

    RNA

    1. XR_379106.3 RNA Sequence

    2. XR_004935297.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6P4T1.1 GenPept UniProtKB/Swiss-Prot:Q6P4T1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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