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    CAF130 CCR4-NOT core subunit CAF130 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853035, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CAF130
    Official Full Name
    CCR4-NOT core subunit CAF130
    Primary source
    SGD:S000003366
    Locus tag
    YGR134W
    See related
    AllianceGenome:SGD:S000003366; FungiDB:YGR134W; VEuPathDB:YGR134W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in positive regulation of transcription elongation by RNA polymerase II. Located in cytosol. Part of CCR4-NOT core complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See CAF130 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (757770..761138)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene prohibitin subunit PHB1 Neighboring gene E2 ubiquitin-protein ligase peroxin 4 Neighboring gene proteasome core particle subunit alpha 3 Neighboring gene Lsb1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Not4-dependent targeting of MMF1 mRNA to mitochondria limits its expression via ribosome pausing, Egd1 ubiquitination, Caf130, no-go-decay and autophagy. Chen S, et al. Nucleic Acids Res, 2023 Jun 9. PMID 37094076, Free PMC Article
    2. Functional similarities and differences among subunits of the nascent polypeptide-associated complex (NAC) of Saccharomyces cerevisiae. Schilke BA, et al. Cell Stress Chaperones, 2024 Oct 18. PMID 39426497, Free PMC Article
    3. Genome wide expression analysis of the CCR4-NOT complex indicates that it consists of three modules with the NOT module controlling SAGA-responsive genes. Cui Y, et al. Mol Genet Genomics, 2008 Apr. PMID 18214544
    4. Specific roles for the Ccr4-Not complex subunits in expression of the genome. Azzouz N, et al. RNA, 2009 Mar. PMID 19155328, Free PMC Article
    5. Insights into the structure of the CCR4-NOT complex by electron microscopy. Nasertorabi F, et al. FEBS Lett, 2011 Jul 21. PMID 21669201, Free PMC Article

    See all (63) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Not4-dependent targeting of MMF1 mRNA to mitochondria limits its expression via ribosome pausing, Egd1 ubiquitination, Caf130, no-go-decay and autophagy.
      Title: Not4-dependent targeting of MMF1 mRNA to mitochondria limits its expression via ribosome pausing, Egd1 ubiquitination, Caf130, no-go-decay and autophagy.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of transcription elongation by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of CCR4-NOT core complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    CCR4-NOT core subunit CAF130
    NP_011650.3
    • Subunit of the CCR4-NOT transcriptional regulatory complex; CCR4-NOT complex is evolutionarily-conserved and involved in controlling mRNA initiation, elongation, and degradation

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      757770..761138
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181263.3 → NP_011650.3  TPA: CCR4-NOT core subunit CAF130 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011650.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VUR6, P53280
      UniProtKB/TrEMBL
      A6ZUE8, C7GUG1, N1P2C4
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53280.1

    Gene LinkOut

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