MLP2 Mlp2p [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: MLP2
Official Full Name: Mlp2p
Primary source: SGD:S000001411
Locus tag: YIL149C
See related: AllianceGenome:SGD:S000001411; FungiDB:YIL149C; VEuPathDB:YIL149C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables ribonucleoprotein complex binding activity. Involved in several processes, including negative regulation of protein import into nucleus during spindle assembly checkpoint; nucleocytoplasmic transport; and post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery. Located in nuclear envelope; nucleoplasm; and spindle pole body. Part of nuclear pore nuclear basket. Used to study lung cancer. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder. Orthologous to human TPR (translocated promoter region, nuclear basket protein). [provided by Alliance of Genome Resources, Nov 2024]
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Chromosome IX - NC_001141.2 Genomic Context describing neighboring genes

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Mlp1p and Mlp2p are necessary components of the nuclear basket and they embed the nuclear pore complex within a dynamic protein network
Title: The nuclear basket proteins Mlp1p and Mlp2p are part of a dynamic interactome including Esc1p and the proteasome.
Mlps link mRNA transcription and export
Title: Perinuclear Mlp proteins downregulate gene expression in response to a defect in mRNA export.
Mlp2p links the SPB to the peripheral Mlp assembly, and this linkage is required for efficient incorporation of components into the SPB.
Title: The nuclear pore complex-associated protein, Mlp2p, binds to the yeast spindle pole body and promotes its efficient assembly.
Mlps play important roles in regulating Ulp1 and subsequently affect sumoylation stasis, growth, and DNA repair.
Title: Mlp-dependent anchorage and stabilization of a desumoylating enzyme is required to prevent clonal lethality.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables ribonucleoprotein complex binding	IGI Inferred from Genetic Interaction more info	PubMed
enables ribonucleoprotein complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables structural constituent of nuclear pore	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in mRNA export from nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA transport	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of protein import into nucleus during spindle assembly checkpoint	IGI Inferred from Genetic Interaction more info	PubMed
involved_in poly(A)+ mRNA export from nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein import into nucleus	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA-templated transcription	IGI Inferred from Genetic Interaction more info	PubMed
involved_in spindle pole body organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in telomere tethering at nuclear periphery	IGI Inferred from Genetic Interaction more info	PubMed
involved_in transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
located_in nuclear envelope	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear envelope	IEA Inferred from Electronic Annotation more info
part_of nuclear pore	IBA Inferred from Biological aspect of Ancestor more info
part_of nuclear pore	IEA Inferred from Electronic Annotation more info
part_of nuclear pore nuclear basket	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in spindle pole body	IEA Inferred from Electronic Annotation more info
located_in spindle pole body	IPI Inferred from Physical Interaction more info	PubMed

NP_012117.3

Myosin-like protein associated with the nuclear envelope; nuclear basket protein that connects the nuclear pore complex with the nuclear interior; involved in the Tel1p pathway that controls telomere length; MLP2 has a paralog, MLP1, that arose from the whole genome duplication

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The following sections contain reference sequences that belong to a specific genome build. Explain