Adamts2 ADAM metallopeptidase with thrombospondin type 1 motif 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Adamts2provided by MGI
Official Full Name: ADAM metallopeptidase with thrombospondin type 1 motif 2provided by MGI
Primary source: MGI:MGI:1347356
See related: Ensembl:ENSMUSG00000036545 AllianceGenome:MGI:1347356
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: pNPI; PCINP; PC I-NP; ADAM-TS2; ADAMTS-2; ADAM-TS 2
Summary: This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin repeats) family of proteinases that is involved in the proteolytic processing of procollagens. The encoded protein precursor is proteolytically processed to generate a mature, zinc-dependent enzyme. Mice lacking the encoded protein develop abnormal lungs, fragile skin and male sterility. [provided by RefSeq, Aug 2015]
Expression: Biased expression in ovary adult (RPKM 48.4), subcutaneous fat pad adult (RPKM 22.7) and 10 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B1.3; 11 30.78 cM

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (50492912..50698400)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (50602085..50807573)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ADAMTS2 promotes radial migration by activating TGF-beta signaling in the developing neocortex.
Title: ADAMTS2 promotes radial migration by activating TGF-β signaling in the developing neocortex.
Opposing roles for ADAMTS2 and ADAMTS14 in myofibroblast differentiation and function.
Title: Opposing roles for ADAMTS2 and ADAMTS14 in myofibroblast differentiation and function.
ADAMTS-2 significantly contributes to the N-t cleavage and inactivation of Reelin in the postnatal cerebral cortex and hippocampus, but much less in the cerebellum.
Title: A disintegrin and metalloproteinase with thrombospondin motifs 2 cleaves and inactivates Reelin in the postnatal cerebral cortex and hippocampus, but not in the cerebellum.
Mice lacking Adamts2 and Adamts14 develop spontaneous atopic dermatitis due to immune dysregulation.
Title: Spontaneous atopic dermatitis due to immune dysregulation in mice lacking Adamts2 and 14.
ADAMTS2 plays a critical role in cardiac hypertrophy induced by pressure overload in mouse model.
Title: Critical Role of ADAMTS2 (A Disintegrin and Metalloproteinase With Thrombospondin Motifs 2) in Cardiac Hypertrophy Induced by Pressure Overload.
Data show that the high titer and specific rabbit anti-ADAMTS2 antibody has been prepared successfully.
Title: [Preparation of rabbit polyclonal antibody against mouse ADAMTS2].
There is no significant genotype effect of ADAMTS2 on age, height, weight, BMI or sex on risk of Achilles tendon pathology.
Title: Polymorphic variation within the ADAMTS2, ADAMTS14, ADAMTS5, ADAM12 and TIMP2 genes and the risk of Achilles tendon pathology: a genetic association study.
Data show that ADAMTS-2 is able to reduce proliferation of endothelial cells, and to induce their retraction and detachment from the substrate resulting in apoptosis.
Title: ADAMTS-2 functions as anti-angiogenic and anti-tumoral molecule independently of its catalytic activity.
Data show thatincreased mRNA of Lamb3 and Adamts2 and enhanced activities of metalloproteinases MMP1, 2 and 7 in transgenic mice expressing the HLA-DQ8.
Title: A deregulated immune response to gliadin causes a decreased villus height in DQ8 transgenic mice.
The extent of liver fibrosis is reduced in ADAMTS2-deficient mice in comparison with their wild type littermates.
Title: ADAM metallopeptidase with thrombospondin type 1 motif 2 inactivation reduces the extent and stability of carbon tetrachloride-induced hepatic fibrosis in mice.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6) 1 citation
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D11Sac9 (e-PCR)
- UniSTS:63233

18.MMHAP75FRF9.seq (e-PCR)
- UniSTS:160090

D11Sac19 (e-PCR)
- UniSTS:62356

Adamts2 (e-PCR), detects polymorphism
- UniSTS:532648

D11Sac18 (e-PCR)
- UniSTS:22494

D11Sac17 (e-PCR)
- UniSTS:11502

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables metalloendopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metalloendopeptidase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in collagen catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within collagen fibril organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in extracellular matrix organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within lung development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within skin development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in collagen-containing extracellular matrix	IEA Inferred from Electronic Annotation more info
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular matrix	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: A disintegrin and metalloproteinase with thrombospondin motifs 2

Names: a disintegrin and metalloproteinase with thrombospondin repeats; a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 2; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 2; procollagen I/II amino propeptide-processing enzyme; procollagen N-endopeptidase; procollagen N-proteinase

NP_783574.1

EC 3.4.24.14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_175643.3 → NP_783574.1 A disintegrin and metalloproteinase with thrombospondin motifs 2 preproprotein

See identical proteins and their annotated locations for NP_783574.1

Status: REVIEWED

Source sequence(s)

AK040370, AL627215, AL645611, AL645639, CJ068037

Consensus CDS

CCDS24636.1

UniProtKB/Swiss-Prot

Q8C9W3

UniProtKB/TrEMBL

A0A5F8MPY1

Related

ENSMUSP00000040171.9, ENSMUST00000040523.9

Conserved Domains (6) summary

smart00209
Location:565 → 617

TSP1; Thrombospondin type 1 repeats

cd04273
Location:267 → 468

ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...

pfam01421
Location:269 → 471

Reprolysin; Reprolysin (M12B) family zinc metalloprotease

pfam01562
Location:99 → 210

Pep_M12B_propep; Reprolysin family propeptide

pfam05986
Location:724 → 838

ADAM_spacer1; ADAM-TS Spacer 1

pfam08686
Location:1064 → 1094

PLAC; PLAC (protease and lacunin) domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

50492912..50698400

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GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001277305.1: Suppressed sequence

Description

NM_001277305.1: This RefSeq was removed because currently there is insufficient support for the transcript.