Prmt5 protein arginine N-methyltransferase 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Prmt5provided by MGI
Official Full Name: protein arginine N-methyltransferase 5provided by MGI
Primary source: MGI:MGI:1351645
See related: Ensembl:ENSMUSG00000023110 AllianceGenome:MGI:1351645
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Jbp1; Skb1
Summary: This gene encodes an enzyme that belongs to the methyltransferase family. The encoded protein catalyzes the transfer of methyl groups to the amino acid arginine, in target proteins that include histones, transcriptional elongation factors and the tumor suppressor p53. This gene plays a role in several cellular processes, including transcriptional regulation and the assembly of small nuclear ribonucleoproteins. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 31.6), CNS E14 (RPKM 26.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 C2; 14 27.82 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (54744639..54754927, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (54507182..54517470, complement)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Protein arginine methyltransferase 5 in osteoblasts promotes the healing of extraction sockets.
Title: Protein arginine methyltransferase 5 in osteoblasts promotes the healing of extraction sockets.
Excessive fatty acids activate PRMT5/MDM2/Drosha pathway to regulate miRNA biogenesis and lipid metabolism.
Title: Excessive fatty acids activate PRMT5/MDM2/Drosha pathway to regulate miRNA biogenesis and lipid metabolism.
PRMT5 Promotes T follicular helper Cell Differentiation and Germinal Center Responses during Influenza Virus Infection.
Title: PRMT5 Promotes T follicular helper Cell Differentiation and Germinal Center Responses during Influenza Virus Infection.
Fibroblast-specific PRMT5 deficiency suppresses cardiac fibrosis and left ventricular dysfunction in male mice.
Title: Fibroblast-specific PRMT5 deficiency suppresses cardiac fibrosis and left ventricular dysfunction in male mice.
PRMT5-mediated homologous recombination repair is essential to maintain genomic integrity of neural progenitor cells.
Title: PRMT5-mediated homologous recombination repair is essential to maintain genomic integrity of neural progenitor cells.
Genetic screen identified PRMT5 as a neuroprotection target against cerebral ischemia.
Title: Genetic screen identified PRMT5 as a neuroprotection target against cerebral ischemia.
PRMT5 regulates epigenetic changes in suppressive Th1-like iTregs in response to IL-12 treatment.
Title: PRMT5 regulates epigenetic changes in suppressive Th1-like iTregs in response to IL-12 treatment.
PRMT5 mediates FoxO1 methylation and subcellular localization to regulate lipophagy in myogenic progenitors.
Title: PRMT5 mediates FoxO1 methylation and subcellular localization to regulate lipophagy in myogenic progenitors.
Prmt5 deficient mouse B cells display RNA processing complexity and slower colorectal tumor progression.
Title: Prmt5 deficient mouse B cells display RNA processing complexity and slower colorectal tumor progression.
The arginine methyltransferase PRMT5 promotes mucosal defense in the intestine.
Title: The arginine methyltransferase PRMT5 promotes mucosal defense in the intestine.

Submit: New GeneRIF Correction See all GeneRIFs (79)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)
Gene trapped (1)
Targeted (7) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:237181

BB342289 (e-PCR)
- UniSTS:208525

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables E-box binding	IDA Inferred from Direct Assay more info	PubMed
enables chromatin binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables histone H2AQ104 methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AR3 methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone H3K37 methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K56 methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3R17 methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3R2 methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3R26 methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3R8 methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H4K12 methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H4R3 methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone H4R3 methyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables histone H4R3 methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables histone H4R3 methyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables histone arginine N-methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables histone arginine N-methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables methyl-CpG binding	ISO Inferred from Sequence Orthology more info
enables methyl-CpG binding	ISS Inferred from Sequence or Structural Similarity more info
enables methyltransferase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables p53 binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info	PubMed
enables protein-arginine N-methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables protein-arginine N-methyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein-arginine omega-N symmetric methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables protein-arginine omega-N symmetric methyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables ribonucleoprotein complex binding	ISO Inferred from Sequence Orthology more info
enables transcription corepressor activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA-templated transcription termination	ISO Inferred from Sequence Orthology more info
involved_in DNA-templated transcription termination	ISS Inferred from Sequence or Structural Similarity more info
involved_in Golgi ribbon formation	ISO Inferred from Sequence Orthology more info
involved_in Golgi ribbon formation	ISS Inferred from Sequence or Structural Similarity more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	ISO Inferred from Sequence Orthology more info
involved_in circadian regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endothelial cell activation	ISO Inferred from Sequence Orthology more info
involved_in gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression via chromosomal CpG island methylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within peptidyl-arginine N-methylation	ISO Inferred from Sequence Orthology more info	PubMed
involved_in peptidyl-arginine methylation	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-arginine methylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mRNA splicing, via spliceosome	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of oligodendrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in spliceosomal snRNP assembly	ISO Inferred from Sequence Orthology more info
involved_in spliceosomal snRNP assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in spliceosomal snRNP assembly	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi apparatus	ISS Inferred from Sequence or Structural Similarity more info
located_in chromatin	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
part_of histone methyltransferase complex	IDA Inferred from Direct Assay more info	PubMed
part_of histone methyltransferase complex	ISO Inferred from Sequence Orthology more info
located_in male germ cell nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of methylosome	ISO Inferred from Sequence Orthology more info
part_of methylosome	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	NAS Non-traceable Author Statement more info	PubMed
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein arginine N-methyltransferase 5

Names: Jak-binding protein 1; SKB1 homolog; histone-arginine N-methyltransferase PRMT5; shk1 kinase-binding protein 1 homolog

NP_001300835.1

EC 2.1.1.320

NP_001300836.1

EC 2.1.1.320

NP_038796.2

EC 2.1.1.320

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001313906.1 → NP_001300835.1 protein arginine N-methyltransferase 5 isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (2) contains an alternate 5' terminal exon, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.

Source sequence(s)

AK076346, AK084106, AK165165, CF726158

UniProtKB/Swiss-Prot

Q3TNN1, Q8CIG8, Q9QZS9

Conserved Domains (2) summary

pfam05185
Location:164 → 600

PRMT5; PRMT5 arginine-N-methyltransferase

pfam16950
Location:165 → 446

SAMBD; SAM-binding_domain
NM_001313907.1 → NP_001300836.1 protein arginine N-methyltransferase 5 isoform 3

Status: REVIEWED

Description

Transcript Variant: This variant (3) contains a distinct 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. The encoded isoform (3) has a shorter N-terminus, compared to isoform 1.

Source sequence(s)

AK076346, AK084106, AK165165, BY101080

UniProtKB/Swiss-Prot

Q3TNN1, Q8CIG8, Q9QZS9

Conserved Domains (2) summary

pfam05185
Location:77 → 513

PRMT5; PRMT5 arginine-N-methyltransferase

pfam16950
Location:78 → 359

SAMBD; SAM-binding_domain
NM_013768.3 → NP_038796.2 protein arginine N-methyltransferase 5 isoform 1

See identical proteins and their annotated locations for NP_038796.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AK076346, AK165165, BY064945

Consensus CDS

CCDS27091.1

UniProtKB/Swiss-Prot

Q3TNN1, Q8CIG8, Q9QZS9

UniProtKB/TrEMBL

A0A0R4J049

Related

ENSMUSP00000023873.6, ENSMUST00000023873.12

Conserved Domains (2) summary

pfam05185
Location:183 → 619

PRMT5; PRMT5 arginine-N-methyltransferase

pfam16950
Location:184 → 465

SAMBD; SAM-binding_domain