Rhox5 reproductive homeobox 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rhox5provided by MGI
Official Full Name: reproductive homeobox 5provided by MGI
Primary source: MGI:MGI:97538
See related: Ensembl:ENSMUSG00000095180 AllianceGenome:MGI:97538
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Pem
Summary: Enables DNA-binding transcription activator activity, RNA polymerase II-specific. Acts upstream of or within ectopic germ cell programmed cell death; flagellated sperm motility; and regulation of DNA-templated transcription. Located in cytoplasm and nucleus. Is expressed in several structures, including early conceptus; genitourinary system; heart; respiratory system; and vertebral axis musculature. [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward placenta adult (RPKM 325.1) See more
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Genomic context

Location:: X A3.3; X

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (36891657..36897305)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (37754608..37808878)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Concordant Androgen-Regulated Expression of Divergent Rhox5 Promoters in Sertoli Cells.
Title: Concordant Androgen-Regulated Expression of Divergent Rhox5 Promoters in Sertoli Cells.
ata indicate that androgen receptor (AR) regulation on Klk27, Rhox5, Eppin, and Cyp17 genes in adult mouse testis using chromatin immunoprecipitation (ChIP) assays.
Title: Androgen receptor binding sites identified in mouse testis.
RHOX5 is a central transcription factor that promotes the survival of male germ cells via its effects on cellular metabolism.
Title: The RHOX homeodomain proteins regulate the expression of insulin and other metabolic regulators in the testis.
suggests a model in which Rhox8 transcription is dependent upon RHOX5 during early folliculogenesis and upon progesterone during the periovulatory window when RHOX5 normally wanes.
Title: Regulated expression of Rhox8 in the mouse ovary: evidence for the role of progesterone and RHOX5 in granulosa cells.
regulates the expression of other Rhox genes in the epididymis
Title: The Rhox5 homeobox gene regulates the region-specific expression of its paralogs in the rodent epididymis.
Ras signaling-dependent Rhox5 expression promotes tumor growth, Rhox5 may be an ideal target for therapeutic intervention in cancer.
Title: Homeobox gene Rhox5 is regulated by epigenetic mechanisms in cancer and stem cells and promotes cancer growth.
ATRX and the androgen receptor (AR) physically interact in the testis and in the Sertoli cell line TM4 and co-operatively activate the promoter of Rhox5.
Title: Defective survival of proliferating Sertoli cells and androgen receptor function in a mouse model of the ATR-X syndrome.
Histone H1 silences Rhox5 transcription by promoting methylation of one of its promoters.
Title: The rhox homeobox gene cluster is imprinted and selectively targeted for regulation by histone h1 and DNA methylation.
Data suggest Rhox5 serves as key intermediate transcription factor that directs some actions of androgen receptor in testes.
Title: Androgen-induced Rhox homeobox genes modulate the expression of AR-regulated genes.
It suggested that the C-terminal domain of prosaposin may be critical for the Rhox5-prosaposin interaction.
Title: Identification of prosaposin as a novel interaction partner for Rhox5.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Pem (e-PCR), detects polymorphism
- UniSTS:144167

Pem (e-PCR), detects polymorphism
- UniSTS:144168

DXWox35 (e-PCR)
- UniSTS:240185

Rhox5 (e-PCR), detects polymorphism
- UniSTS:508554

RH124872 (e-PCR)
- UniSTS:161694

Rhox5 (e-PCR), detects polymorphism
- UniSTS:546978

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within ectopic germ cell programmed cell death	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within flagellated sperm motility	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in chromatin	IC Inferred by Curator more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: homeobox protein Rhox5

Names: homeobox protein Pem; placenta and embryonic expression protein; placentae and embryos oncofetal; reproductive homeobox on X chromosome, 5; reproductive homeobox on chromosome X 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.