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    Utp25 UTP25 small subunit processome component [ Mus musculus (house mouse) ]

    Gene ID: 215193, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Utp25provided by MGI
    Official Full Name
    UTP25 small subunit processome componentprovided by MGI
    Primary source
    MGI:MGI:2138080
    See related
    Ensembl:ENSMUSG00000016181 AllianceGenome:MGI:2138080
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Def; mDef; Diexf
    Summary
    Predicted to enable U3 snoRNA binding activity and rRNA binding activity. Involved in positive regulation of embryonic development. Predicted to be part of small-subunit processome. Predicted to be active in nucleolus. Is expressed in cerebral cortex; submandibular gland primordium; tooth; and vibrissa. Orthologous to human UTP25 (UTP25 small subunit processome component). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 6.5), limb E14.5 (RPKM 4.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Utp25 in Genome Data Viewer
    Location:
    1 H6; 1 97.56 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (192786707..192812603, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (193104399..193130283, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene synaptotagmin XIV Neighboring gene predicted gene, 39746 Neighboring gene predicted gene, 31406 Neighboring gene predicted gene, 39747 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:194913524-194913725 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:194948976-194949260 Neighboring gene STARR-positive B cell enhancer ABC_E3355 Neighboring gene RIKEN cDNA A130010J15 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:194995551-194995752 Neighboring gene STARR-positive B cell enhancer ABC_E7790 Neighboring gene interferon regulatory factor 6 Neighboring gene TRAF3 interacting protein 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Ribosome biogenesis gene DEF/UTP25 is essential for liver homeostasis and regeneration. Huang W, et al. Sci China Life Sci, 2020 Nov. PMID 32303961
    2. Hepatic depletion of nucleolar protein mDEF causes excessive mitochondrial copper accumulation associated with p53 and NRF1 activation. Wei J, et al. iScience, 2023 Jul 21. PMID 37456842, Free PMC Article
    3. Loss of digestive organ expansion factor (Diexf) reveals an essential role during murine embryonic development that is independent of p53. Aryal NK, et al. Oncotarget, 2017 Nov 28. PMID 29262616, Free PMC Article
    4. LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow. Tseng HY, et al. J Cell Sci, 2018 Nov 21. PMID 30333137, Free PMC Article
    5. Tagging genes with cassette-exchange sites. Cobellis G, et al. Nucleic Acids Res, 2005 Mar 1. PMID 15741177, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ribosome biogenesis gene DEF/UTP25 is essential for liver homeostasis and regeneration.
      Title: Ribosome biogenesis gene DEF/UTP25 is essential for liver homeostasis and regeneration.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables U3 snoRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables U3 snoRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables rRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in embryonic organ development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in embryonic organ development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein destabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein destabilization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein localization to nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to nucleolus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of small-subunit processome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    U3 small nucleolar RNA-associated protein 25 homolog
    Names
    UTP25 small subunit processor component
    digestive-organ expansion factor homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001368818.2 → NP_001355747.1  U3 small nucleolar RNA-associated protein 25 homolog isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL365322
      UniProtKB/Swiss-Prot
      Q8BTT6, Q8BWJ1, Q8VEC2
      Conserved Domains (1) summary
      pfam06862
      Location:175 → 650
      UTP25; Utp25, U3 small nucleolar RNA-associated SSU processome protein 25

    2. NM_001368819.2 → NP_001355748.1  U3 small nucleolar RNA-associated protein 25 homolog isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL365322
      Conserved Domains (1) summary
      pfam06862
      Location:288 → 510
      UTP25; Utp25, U3 small nucleolar RNA-associated SSU processome protein 25

    3. NM_145415.3 → NP_663390.2  U3 small nucleolar RNA-associated protein 25 homolog isoform 1

      See identical proteins and their annotated locations for NP_663390.2

      Status: VALIDATED

      Source sequence(s)
      AL365322
      Consensus CDS
      CCDS15631.1
      UniProtKB/Swiss-Prot
      Q8BTT6, Q8BWJ1, Q8VEC2
      UniProtKB/TrEMBL
      A0A0R4J114
      Related
      ENSMUSP00000082691.2, ENSMUST00000085555.7
      Conserved Domains (1) summary
      pfam06862
      Location:288 → 763
      UTP25; Utp25, U3 small nucleolar RNA-associated SSU processome protein 25

    RNA

    1. NR_151719.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL365322
      Related
      ENSMUST00000195291.6

    2. NR_185200.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL365322

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      192786707..192812603 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030252943.2 → XP_030108803.1  U3 small nucleolar RNA-associated protein 25 homolog isoform X1

      UniProtKB/Swiss-Prot
      Q8BTT6, Q8BWJ1, Q8VEC2
      Conserved Domains (1) summary
      pfam06862
      Location:175 → 650
      UTP25; Utp25, U3 small nucleolar RNA-associated SSU processome protein 25

    2. XM_006497250.2 → XP_006497313.1  U3 small nucleolar RNA-associated protein 25 homolog isoform X2

      Conserved Domains (1) summary
      pfam06862
      Location:1 → 466
      UTP25; Utp25, U3 small nucleolar RNA-associated SSU processome protein 25

    RNA

    1. XR_004941611.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BTT6.2 GenPept UniProtKB/Swiss-Prot:Q8BTT6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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