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    Mgat5b mannoside acetylglucosaminyltransferase 5, isoenzyme B [ Mus musculus (house mouse) ]

    Gene ID: 268510, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mgat5bprovided by MGI
    Official Full Name
    mannoside acetylglucosaminyltransferase 5, isoenzyme Bprovided by MGI
    Primary source
    MGI:MGI:3606200
    See related
    Ensembl:ENSMUSG00000043857 AllianceGenome:MGI:3606200
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GnT-IX; mGnTVB; C330018B01
    Summary
    Enables alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity. Acts upstream of or within protein N-linked glycosylation. Located in Golgi apparatus. Is expressed in inner ear; nervous system; and neural ectoderm. Orthologous to human MGAT5B (alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in whole brain E14.5 (RPKM 22.3), CNS E18 (RPKM 20.1) and 8 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mgat5b in Genome Data Viewer
    Location:
    11 E2; 11 81.49 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (116809629..116877770)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (116918853..116986944)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7102 Neighboring gene STARR-positive B cell enhancer ABC_E4018 Neighboring gene STARR-positive B cell enhancer ABC_E2376 Neighboring gene methyltransferase like 23 Neighboring gene jumonji domain containing 6 Neighboring gene major facilitator superfamily domain containing 11 Neighboring gene serine and arginine-rich splicing factor 2 Neighboring gene STARR-seq mESC enhancer starr_31229 Neighboring gene STARR-seq mESC enhancer starr_31231 Neighboring gene predicted gene, 33829 Neighboring gene STARR-seq mESC enhancer starr_31232 Neighboring gene STARR-seq mESC enhancer starr_31233 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:116898528-116898729 Neighboring gene predicted gene 11728 Neighboring gene microRNA 6516 Neighboring gene small nucleolar RNA host gene 20

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Epigenetic regulation of a brain-specific glycosyltransferase N-acetylglucosaminyltransferase-IX (GnT-IX) by specific chromatin modifiers. Kizuka Y, et al. J Biol Chem, 2014 Apr 18. PMID 24619417, Free PMC Article
    2. Brain-specific expression of N-acetylglucosaminyltransferase IX (GnT-IX) is regulated by epigenetic histone modifications. Kizuka Y, et al. J Biol Chem, 2011 Sep 9. PMID 21771782, Free PMC Article
    3. Loss of branched O-mannosyl glycans in astrocytes accelerates remyelination. Kanekiyo K, et al. J Neurosci, 2013 Jun 12. PMID 23761899, Free PMC Article
    4. Developmental expression of the neuron-specific N-acetylglucosaminyltransferase Vb (GnT-Vb/IX) and identification of its in vivo glycan products in comparison with those of its paralog, GnT-V. Lee JK, et al. J Biol Chem, 2012 Aug 17. PMID 22715095, Free PMC Article
    5. Brain-specific glycosylation enzyme GnT-IX maintains levels of protein tyrosine phosphatase receptor PTPRZ, thereby mediating glioma growth. Nagai K, et al. J Biol Chem, 2023 Sep. PMID 37543361, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Brain-specific glycosylation enzyme GnT-IX maintains levels of protein tyrosine phosphatase receptor PTPRZ, thereby mediating glioma growth.
      Title: Brain-specific glycosylation enzyme GnT-IX maintains levels of protein tyrosine phosphatase receptor PTPRZ, thereby mediating glioma growth.
    2. a new epigenetic mechanism of brain-specific GnT-IX expression regulated by defined chromatin modifiers, providing new insights into the tissue-specific expression of glycosyltransferases.
      Title: Epigenetic regulation of a brain-specific glycosyltransferase N-acetylglucosaminyltransferase-IX (GnT-IX) by specific chromatin modifiers.
    3. This study demonistrated that Loss of branched O-mannosyl glycans in astrocytes accelerates remyelination in animal disease model of Demyelinating Disease in mice.
      Title: Loss of branched O-mannosyl glycans in astrocytes accelerates remyelination.
    4. Developmental expression of the neuron-specific N-acetylglucosaminyltransferase Vb (GnT-Vb/IX) and identification of its in vivo glycan products in comparison with those of its paralog, GnT-V.
      Title: Developmental expression of the neuron-specific N-acetylglucosaminyltransferase Vb (GnT-Vb/IX) and identification of its in vivo glycan products in comparison with those of its paralog, GnT-V.
    5. revealed that the genomic region around the transcriptional start site of the acetylglucosaminyltransferase IX gene was highly associated with active chromatin histone marks in a neural cell-specific manner.
      Title: Brain-specific expression of N-acetylglucosaminyltransferase IX (GnT-IX) is regulated by epigenetic histone modifications.
    6. GnT-IX transcripts were restricted to the cerebrum, cerebellum, thymus and testis, whereas GnT-V transcripts were expressed ubiquitously in mouse tissues
      Title: Demonstration of the expression and the enzymatic activity of N-acetylglucosaminyltransferase IX in the mouse brain.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 
    • Targeted (5)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables manganese ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables manganese ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein N-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein N-linked glycosylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein O-linked glycosylation via serine IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein O-linked glycosylation via serine ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B
    Names
    GNT-Vb
    N-acetylglucosaminyl-transferase Vb
    N-acetylglucosaminyltranferase VB
    N-acetylglucosaminyltransferase IX
    UDP-N-acetylglucosamine: alpha1,6-D-mannoside beta1,6-N-acetylglucosaminyltransferase b
    alpha-mannoside beta-1,6-N-acetylglucosaminyltransferase B
    beta1,6-N-acetylglucosaminyltransferase IX (GnT-IX)
    glcNAc-T Vb
    mannoside acetylglucosaminyltransferase 5B
    NP_766536.2
    XP_006533480.1
    XP_036012613.1
    XP_036012614.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172948.3 → NP_766536.2  alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B

      See identical proteins and their annotated locations for NP_766536.2

      Status: PROVISIONAL

      Source sequence(s)
      BC094604
      Consensus CDS
      CCDS25682.1
      UniProtKB/Swiss-Prot
      Q765H6, Q8C7T8
      Related
      ENSMUSP00000099316.4, ENSMUST00000103027.10
      Conserved Domains (1) summary
      pfam15024
      Location:184 → 777
      Glyco_transf_18; Glycosyltransferase family 18

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      116809629..116877770
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006533417.5 → XP_006533480.1  alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B isoform X2

      Conserved Domains (1) summary
      pfam15024
      Location:147 → 740
      Glyco_transf_18; Glycosyltransferase family 18

    2. XM_036156721.1 → XP_036012614.1  alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B isoform X3

      Conserved Domains (1) summary
      pfam15024
      Location:147 → 738
      Glyco_transf_18; Glycosyltransferase family 18

    3. XM_036156720.1 → XP_036012613.1  alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B isoform X1

      Conserved Domains (1) summary
      pfam15024
      Location:184 → 775
      Glyco_transf_18; Glycosyltransferase family 18

    RNA

    1. XR_388471.4 RNA Sequence

    2. XR_001780011.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q765H6.1 GenPept UniProtKB/Swiss-Prot:Q765H6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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