Naa11 N(alpha)-acetyltransferase 11, NatA catalytic subunit [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Naa11provided by MGI
Official Full Name: N(alpha)-acetyltransferase 11, NatA catalytic subunitprovided by MGI
Primary source: MGI:MGI:2141314
See related: Ensembl:ENSMUSG00000046000 AllianceGenome:MGI:2141314
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ard2; Ard1b
Summary: Predicted to enable peptide-glutamate-alpha-N-acetyltransferase activity and peptide-serine-alpha-N-acetyltransferase activity. Predicted to be involved in N-terminal protein amino acid acetylation. Predicted to be located in several cellular components, including Golgi apparatus; centrosome; and nucleoplasm. Predicted to be part of NatA complex. Is expressed in embryo; metanephros; and testis. Orthologous to human NAA11 (N-alpha-acetyltransferase 11, NatA catalytic subunit). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward testis adult (RPKM 4.4) See more
Orthologs: human all
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Genomic context

Location:: 5 E3; 5 47.62 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (97530068..97540189, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (97382209..97392330, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

cloning, characterization, and expression pattern of Ard1b; results suggest that ARD1B may have an important role in the later course of the spermatogenic process
Title: Cloning, characterization, and expression analysis of the novel acetyltransferase retrogene Ard1b in the mouse.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Naa11 (e-PCR), detects polymorphism
- UniSTS:528304

RH126783 (e-PCR)
- UniSTS:207831

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables peptide alpha-N-acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables peptide-alanine-alpha-N-acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables peptide-glutamate-alpha-N-acetyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables peptide-serine-alpha-N-acetyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables peptide-serine-alpha-N-acetyltransferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in N-terminal protein amino acid acetylation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
part_of NatA complex	IBA Inferred from Biological aspect of Ancestor more info
part_of NatA complex	IEA Inferred from Electronic Annotation more info
part_of NatA complex	ISO Inferred from Sequence Orthology more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: N-alpha-acetyltransferase 11

Names: ARD1 homolog B; N-terminal acetyltransferase complex ARD1 subunit homolog B; Nalpha acteyltransferase 11; arrest defective 2; natA catalytic subunit Naa11

NP_001028363.1

EC 2.3.1.255

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001033191.2 → NP_001028363.1 N-alpha-acetyltransferase 11

See identical proteins and their annotated locations for NP_001028363.1

Status: PROVISIONAL

Source sequence(s)

AK135863

Consensus CDS

CCDS19453.1

UniProtKB/Swiss-Prot

Q3UX61, Q3V0C7

UniProtKB/TrEMBL

A8W660

Related

ENSMUSP00000057336.5, ENSMUST00000060265.6

Conserved Domains (2) summary

COG0456
Location:1 → 149

RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]

pfam00583
Location:47 → 122

Acetyltransf_1; Acetyltransferase (GNAT) family