Tmem120a transmembrane protein 120A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tmem120aprovided by MGI
Official Full Name: transmembrane protein 120Aprovided by MGI
Primary source: MGI:MGI:2686991
See related: Ensembl:ENSMUSG00000039886 AllianceGenome:MGI:2686991
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tmpit; 2010310D06Rik
Summary: Enables coenzyme A binding activity and monoatomic ion channel activity. Involved in several processes, including antiviral innate immune response; detection of mechanical stimulus involved in sensory perception of pain; and protein complex oligomerization. Located in nuclear inner membrane and plasma membrane. Is expressed in central nervous system and ganglia. Orthologous to human TMEM120A (transmembrane protein 120A). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in duodenum adult (RPKM 93.9), subcutaneous fat pad adult (RPKM 83.5) and 23 other tissues See more
Orthologs: human all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 5 G2; 5 75.38 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (135764344..135773026, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (135735490..135744172, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TMEM120A/TACAN inhibits mechanically activated PIEZO2 channels.
Title: TMEM120A/TACAN inhibits mechanically activated PIEZO2 channels.
Genomic loci mispositioning in Tmem120a knockout mice yields latent lipodystrophy.
Title: Genomic loci mispositioning in Tmem120a knockout mice yields latent lipodystrophy.
TMEM120A contains a specific coenzyme A-binding site and might not mediate poking- or stretch-induced channel activities in cells.
Title: TMEM120A contains a specific coenzyme A-binding site and might not mediate poking- or stretch-induced channel activities in cells.
TACAN Is an Ion Channel Involved in Sensing Mechanical Pain.
Title: TACAN Is an Ion Channel Involved in Sensing Mechanical Pain.
it is possible that the TMEM120A and B fat-specific nuclear envelope transmembrane proteins may play a contributory role in the tissue-specific pathology of this disorder or in the wider problem of obesity.
Title: TMEM120A and B: Nuclear Envelope Transmembrane Proteins Important for Adipocyte Differentiation.

Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)
Targeted (3) 1 citation

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

D17571 (e-PCR)
- UniSTS:163373

NoName (e-PCR)
- UniSTS:488373

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables coenzyme A binding	IDA Inferred from Direct Assay more info	PubMed
enables monoatomic ion channel activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in antiviral innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in detection of mechanical stimulus involved in sensory perception of pain	IDA Inferred from Direct Assay more info	PubMed
involved_in fat cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in fat cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fat cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in monoatomic ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in protein heterooligomerization	IDA Inferred from Direct Assay more info	PubMed
involved_in protein heterooligomerization	ISO Inferred from Sequence Orthology more info
involved_in protein homooligomerization	IDA Inferred from Direct Assay more info	PubMed
involved_in protein homooligomerization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear inner membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: ion channel TACAN

Names: transmembrane protein induced by tumor necrosis factor alpha

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.